Results 91 to 100 of about 25,031 (241)

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

Advanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang, Haowei Fang, Lili Qi, Song Myoungseop, Aawrish Khan, Lunli Gong, Guangdong Zhou, Kunxi Zhang, Haiyan Cui   +8 more
wiley   +1 more source

Intestinal SR-BI does not impact cholesterol absorption or transintestinal cholesterol efflux in mice

Journal of Lipid Research, 2013
Reverse cholesterol transport (RCT) can proceed through the classic hepatobiliary route or through the nonbiliary transintestinal cholesterol efflux (TICE) pathway.
Kanwardeep S. Bura, Caleb Lord, Stephanie Marshall, Allison McDaniel, Gwyn Thomas, Manya Warrier, Jun Zhang, Matthew A. Davis, Janet K. Sawyer, Ramesh Shah, Martha D. Wilson, Arne Dikkers, Uwe J.F. Tietge, Xavier Collet, Lawrence L. Rudel, Ryan E. Temel, J.Mark Brown   +16 more
doaj   +1 more source

Novel Functions of Endothelial Scavenger Receptor Class B Type I. [PDF]

Curr Atheroscler Rep, 2021
Yu L, Dai Y, Mineo C.
europepmc   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Cellular SR-BI and ABCA1-mediated cholesterol efflux are gender-specific in healthy subjectss⃞

Journal of Lipid Research, 2008
We evaluated the impact of gender differences in both the quantitative and qualitative features of HDL subspecies on cellular free cholesterol efflux through the scavenger receptor class B type I (SR-BI), ABCA1, and ABCG1 pathways.
Giovanna Catalano, Emilie Duchene, Zélie Julia, Wilfried Le Goff, Eric Bruckert, M. John Chapman, Maryse Guerin   +6 more
doaj   +1 more source

Apolipoprotein A1 Modulates Teff/Treg Balance Through Scavenger Receptor Class B Type I-Dependent Mechanisms in Experimental Autoimmune Uveitis. [PDF]

Invest Ophthalmol Vis Sci, 2022
Huang H, Li Z, Huang J, Xie Y, Xiao Z, Hu Y, Chen G, Wang M, Li Z, Chen Q, Zhu W, Su W, Luo Y, Chen X, Liang D.   +14 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Generation of a mouse model for the in vivo study of HCV-host interaction

, 2010
The natural species tropism of hepatitis C virus (HCV) is limited to humans and higher primates. Due to the limited availability of chimpanzees, the establishment of a small-animal model for the study of HCV infection has a high priority.
D'Angelo, Fulvio
core  

Structure and function of the HDL receptor SR-BI : scavenger receptor class B type I

, 2003
Low plasma levels of high-density lipoprotein (HDL) and high levels of low-density lipoprotein (LDL) are well-recognized risk factors for cardiovascular disease.
Johnson, Magnus S.C.,
core   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source