Results 71 to 80 of about 56,399 (161)

The conserved scavenger receptor cysteine-rich superfamily in therapy and diagnosis [PDF]

, 2011
The scavenger receptor cysteine-rich (SRCR) superfamily of soluble or membrane-bound protein receptors is characterized by the presence of one or several repeats of an ancient and highly conserved protein module, the SRCR domain.
Holmskov, Uffe, Lozano, Francisco, Martínez, Vanesa Gabriela, Moestrup, Søren Kragh, Mollenhauer, Jan   +4 more
core   +1 more source

SR-BI-directed HDL-cholesteryl ester hydrolysis

Journal of Lipid Research, 2003
We have examined the metabolic fate of HDL cholesteryl ester (CE) delivered to cells expressing scavenger receptor class B type I (SR-BI). Comparison of SR-BI with a related class B scavenger receptor, CD36, showed a greater uptake and a more rapid and ...
Margery A. Connelly, Ginny Kellner-Weibel, George H. Rothblat, David L. Williams   +3 more
doaj   +1 more source

Challenges in Using Cultured Primary Rodent Hepatocytes or Cell Lines to Study Hepatic HDL Receptor SR-BI Regulation by Its Cytoplasmic Adaptor PDZK1 [PDF]

, 2013
Background: PDZK1 is a four PDZ-domain containing cytoplasmic protein that binds to a variety of membrane proteins via their C-termini and can influence the abundance, localization and/or function of its target proteins.
A Braun, A Brill, A Rigotti, A Rigotti, A Sivaraman, A Yesilaltay, A Yesilaltay, A Yesilaltay, AJ Hwa, B Trigatti, BW Kannel, C Glass, C Glass, CD Rodrigues, CJ Maslansky, DJ Gordon, DL Silver, DM Bissell, E LeCluyse, E Scarselli, G Michalopoulos, HE Miettinen, I Meurs, IM Stylianou, IS Yuhanna, JE Klaunig, K Murao, KF Kozarsky, Kosuke Tsukamoto, KT Landschulz, L Cai, L Richert, Linda Griffith, Lorenna Buck, M Ikemoto, Matias A. Avila, Monty Krieger, NR Webb, NS Eyre, O Kocher, O Kocher, O Kocher, O Kocher, O Kocher, OH Lowry, Olivier Kocher, P Oquendo, Q Guo, R Out, R Out, S Acton, S Saddar, S Yalaoui, SA Fenske, SA Fenske, SC Shih, SC Shih, SJ Korporaal, SM Martinez, T Fu, TJ Nieland, TM Holm, TM Teslovich, VS Dole, Walker Inman, X Gu, Y Ji, Y Stein, Y Wada   +68 more
core   +3 more sources

Scavenger receptor class B type I-mediated uptake of serum cholesterol is essential for optimal adrenal glucocorticoid production

Journal of Lipid Research, 2009
Impaired scavenger receptor class B type I (SR-BI)-mediated uptake of HDL-cholesterol esters (HDL-CE) induces adrenal insufficiency in mice. Humans contain an alternative route of HDL-CE clearance, namely through the transfer by cholesteryl ester ...
Menno Hoekstra, Dan Ye, Reeni B. Hildebrand, Ying Zhao, Bart Lammers, Miranda Stitzinger, Johan Kuiper, Theo J.C. Van Berkel, Miranda Van Eck   +8 more
doaj   +1 more source

Reactivity of human and porcine natural interferon-alpha producing cells to immunostimulatory DNA [PDF]

, 2003
The interferon-α (IFN-α) inducing capacity of various forms of immunostimulatory DNA and the identity of the IFN-α producing cells (IPC) were studied in human and porcine leukocytes.
Magnusson, Mattias
core  

Monoclonal anti-envelope antibody AP33 protects humanized mice against a patient-derived hepatitis C virus challenge [PDF]

, 2016
End-stage liver disease caused by hepatitis C virus (HCV) infection is a major indication for liver transplantation. However, immediately after transplantation the liver graft of viremic patients universally becomes infected by circulating virus ...
Baumert, Thomas F., Cole, Sarah, Desombere, Isabelle, Fafi-Kremer, Samira, Farhoudi, Ali, Heydmann, Laura, Leroux-Roels, Geert, McKeating, Jane A., Meuleman, Philip, Patel, Arvind H., Pessaux, Patrick, Van Houtte, Freya, Verhoye, Lieven   +12 more
core   +3 more sources

Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice

Journal of Lipid Research, 2001
The scavenger receptor class B type I (SR-BI), which is expressed in the liver and intestine, plays a critical role in cholesterol metabolism in rodents.
Pablo Mardones, Verónica Quiñones, Ludwig Amigo, Mauricio Moreno, Juan Francisco Miquel, Margrit Schwarz, Helena E. Miettinen, Bernardo Trigatti, Monty Krieger, Sonya VanPatten, David E. Cohen, Attilio Rigotti   +11 more
doaj   +1 more source

Decreased soluble guanylate cyclase contributes to cardiac dysfunction induced by chronic doxorubicin treatment in mice [PDF]

, 2017
Aims: The use of doxorubicin, a potent chemotherapeutic agent, is limited by cardiotoxicity. We tested the hypothesis that decreased soluble guanylate cyclase (sGC) enzyme activity contributes to the development of doxorubicin-induced cardiotoxicity ...
Allen, Kaitlin, Bartunek, Jozef, Beerens, Manu, Bloch, Donald B, Bloch, Kenneth D, Brouckaert, Peter, Buys, Emmanuel S, Caluwe, Ellen, Gillijns, Hilde, Janssens, Stefan P, Nathan, Daniel I, Scherrer-Crosbie, Marielle, Swinnen, Melissa, Tainsh, Robert E, Vandenwijngaert, Sara, Walravens, Ann-Sophie   +15 more
core   +1 more source

HDL-mediated cholesterol uptake and targeting to lipid droplets in adipocytes

Journal of Lipid Research, 2003
Adipocytes express high levels of the HDL scavenger receptor class B type I in a differentiation-dependent manner. We thus have analyzed the routes of HDL cholesterol trafficking at different phases of adipocyte differentiation in the 3T3-L1 cell line ...
Georges Dagher, Nathalie Donne, Christophe Klein, Pascal Ferré, Isabelle Dugail   +4 more
doaj   +1 more source

Scavenger receptor class B type I genetic variants associated with disease severity in chronic hepatitis C virus infection. [PDF]

J Med Virol, 2023
Arandhara VL, McClure CP, Tarr AW, Chappell S, Morgan K, Baumert TF, Irving WL, Ball JK.   +7 more
europepmc   +1 more source