Results 201 to 210 of about 55,768 (280)

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Class A Scavenger Receptors Are Used by Frog Virus 3 During Its Cellular Entry. [PDF]

Viruses, 2019
Vo NTK, Guerreiro M, Yaparla A, Grayfer L, DeWitte-Orr SJ.   +4 more
europepmc   +1 more source

The Macrophage Scavenger Receptors

The Journal of Japan Atherosclerosis Society, 1990
Tatsuhiko KODAMA, Fumimaro TAKAKU, Akiyo MATSUMOTO, Hiroshige ITAKURA   +3 more
openaire   +2 more sources

Identification of Neutrophil Granule Glycoproteins as Lewisx-containing Ligands Cleared by the Scavenger Receptor C-type Lectin [PDF]

, 2011
Sarah A. Graham, Aristotelis Antonopoulos, Paul G. Hitchen, Stuart M. Haslam, Anne Dell, Kurt Drickamer, Maureen E. Taylor   +6 more
openalex   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease. [PDF]

J Immunol, 2017
PrabhuDas MR, Baldwin CL, Bollyky PL, Bowdish DME, Drickamer K, Febbraio M, Herz J, Kobzik L, Krieger M, Loike J, McVicker B, Means TK, Moestrup SK, Post SR, Sawamura T, Silverstein S, Speth RC, Telfer JC, Thiele GM, Wang XY, Wright SD, El Khoury J.   +21 more
europepmc   +1 more source

Scavenger receptor for aldehyde-modified proteins.

, 1986
Seikoh Horiuchi, Masaji Murakami, Kazuhide Takata, Yoshimasa Morino   +3 more
openalex   +1 more source

Sprouty2 loss‐induced IL 6 drives castration‐resistant prostate cancer through scavenger receptor B1 [PDF]

, 2018
Rachana Patel, Janis Fleming, Ernest Mui, Carolyn J. Loveridge, Peter Repiščák, Arnaud Blomme, Victoria Harle, Mark J. Salji, Imran Ahmad, Katy Teo, Freddie C. Hamdy, Ann Hedley, Niels van den Broek, Gillian Mackay, Joanne Edwards, Owen J. Sansom, Hing Y. Leung   +16 more
openalex   +1 more source

Fermented Lacticaseibacillus Paracasei Cultures Ameliorate Colitis by Modulating Microbiota‐Derived Tryptophan Metabolism and Macrophage Polarization

Advanced Science, EarlyView.
A solid‐state fermented probiotic (PYW) is developed using wheat bran as substrate, containing high viable Lacticaseibacillus paracasei and bioactive metabolites. PYW alleviates intestinal inflammation by gut microbiota composition, enriching indole derivatives, activating aryl hydrocarbon receptor signaling, and regulating macrophage polarization. PYW
Heng Zhang, Jingzhou Sun, Xin Zheng, Huiqing Yang, Aowen Xie, Yuxuan Ding, Yuxia Mei, Jinshan Li, Yuanliang Hu, Min Ren, Yangyang Liu, Yunxiang Liang   +11 more
wiley   +1 more source

Cathelicidin promotes inflammation by enabling binding of self-RNA to cell surface scavenger receptors. [PDF]

Sci Rep, 2018
Takahashi T, Kulkarni NN, Lee EY, Zhang LJ, Wong GCL, Gallo RL.   +5 more
europepmc   +1 more source