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Advanced Science, EarlyView.This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...
Zili Song +14 more
wiley +1 more source
Foam cells: tracing the diverse cellular origins and their linked signaling pathways. [PDF]
J Transl MedJiao X +6 more
europepmc +1 more source
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Endothelial scavenger receptors
Progress in Lipid Research, 2006In the past few decades, cDNAs for endothelial scavenger receptors that bind to negatively charged molecules, particularly acetylated low density lipoproteins (Ac-LDL), have been cloned by expression cloning using modified LDL as ligands. A prototypic members of endothelial scavenger receptor family, namely, scavenger receptor class B type I (SR-BI ...
Hideki, Adachi, Masafumi, Tsujimoto
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Collagenous macrophage scavenger receptors
Current Opinion in Lipidology, 1996Collagen, the most abundant protein in the human body, is a major constituent of extracellular matrix. Among macrophage membrane proteins, type I and II scavenger receptors and MARCO contain a collagenous domain. Analysis of type I and II receptor knockout mice and histochemical studies indicate that these proteins play roles in scavenger, adhesion and
T, Kodama +5 more
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Hemoglobin and Heme Scavenger Receptors
Antioxidants & Redox Signaling, 2010Heme, the functional group of hemoglobin, myoglobin, and other hemoproteins, is a highly toxic substance when it appears in the extracellular milieu. To circumvent potential harmful effects of heme from hemoproteins released during physiological or pathological cell damage (such as hemolysis and rhabdomyolysis), specific high capacity scavenging ...
Nielsen MJ, Møller HJ, Moestrup SK.
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Macrophage scavenger receptors
Current Opinion in Lipidology, 1994Macrophage scavenger receptors are integral membrane proteins whose ability to bind and degrade modified LDL has implicated them in the process of atherosclerotic foam cell formation. Their ability to bind non-lipoprotein ligands suggests that they participate in other macrophage-associated host defense activities.
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Scavenger receptor regulation and atherosclerosis
BioFactors, 2000AbstractAtherosclerosis and its complications, such as coronary heart disease, heart infarction and stroke, are the leading causes of death in the developed world. High blood pressure, diabetes, smoking and a diet high in cholesterol and lipids clearly increase the likelihood of premature atherosclerosis, albeit other factors, such as the individual ...
ZINGG JM, RICCIARELLI, ROBERTA, AZZI A.
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Macrophage scavenger receptors and atherosclerosis
Trends in Cardiovascular Medicine, 1992The fatty streak is the earliest visible atherosclerotic lesion. Microscopically, this lesion consists of a subendothelial collection of macrophage foam cells that are characterized by their content of numerous lipid droplets. Investigations into the mechanisms responsible for foam cell formation have led to the identification of macrophage scavenger ...
H, Wu, K S, Moulton, C K, Glass
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Scavenger-Receptor Targeted Photodynamic Therapy¶
Photochemistry and Photobiology, 2000Covalent conjugation of a photosensitizer to a ligand that specifically recognized and internalized by a cell-surface receptor may be a way of improving the selectivity of photodynamic therapy (PDT). The class A Type-I scavenger receptor of macrophages, which among other ligands recognizes maleylated serum albumin and has a high capacity is a good ...
M R, Hamblin, J L, Miller, B, Ortel
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