Journal of Lipid Research, 2007 Modified forms of LDL, including oxidized low density lipoprotein (OxLDL), contribute to macrophage lipid accumulation in the vessel wall. Despite the pathophysiological importance of uptake pathways for OxLDL, the molecular details of OxLDL endocytosis ...
Bing Sun +5 more
doaj
Scavenger Receptor A: A New Route for Adenovirus 5
Molecular Pharmaceutics, 2009 Adenoviruses are common pathogens associated with respiratory diseases, gastrointestinal illnesses and/or conjunctivitis. Currently, this virus is used as a vector in gene therapy trials. The promise of viral gene therapy applications is substantially reduced because the virus is cleared by liver macrophages upon systemic administration.
Haisma, H +7 more
openaire +3 more sources
Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo
Advanced Healthcare Materials, EarlyView.This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla +16 more
wiley +1 more source
Macrophage Recognition of Crystals and Nanoparticles
Frontiers in Immunology, 2018 Inhalation of exogenous crystals such as silica, asbestos, and carbon nanotubes can cause lung fibrosis and cancer. Endogenous crystals such as monosodium urate, cholesterol, and hydroxyapatite are associated with pathogenesis of gout, atherosclerosis ...
Masafumi Nakayama, Masafumi Nakayama
doaj +1 more source
Scavenger Receptors in Myocardial Infarction and Ischemia/Reperfusion Injury: The Potential for Disease Evaluation and Therapy. [PDF]
J Am Heart Assoc, 2023 Zhang J, Ding W, Liu J, Wan J, Wang M.
europepmc +1 more source
Novel macrophage receptor for glucose-modified proteins is distinct from previously described scavenger receptors. [PDF]
, 1986 Helen Vlassara +2 more
openalex +1 more source
Macrophage Scavenger Receptors and Atherosclerosis
The journal of the Japanese Society of Lymphoreticular Tissue research, 1998 A hallmark of atherosclerosis is the deposition of plasma cholesterol in atherosclerotic plaques in arterial walls. Key cellular components of atherosclerotic plaques are foam cells, which are derived from monocytes-macrophages. In order to elucidate the molecular mechanism of foam cell formation, we cloned and characterized cDNA for type I and II MSR.
openaire +3 more sources
Progress of Immune‐Inducible Biomaterials for Post‐Ablation Cancers
Advanced Healthcare Materials, EarlyView.The presence of residual tumors after ablative therapies poses a significant challenge, generally resulting in recurrence and metastases. This review offers a concise overview of immune‐inducible biomaterials from the perspective of the cancer‐immunity cycle, and how they enhance antitumor immunity through diverse mechanisms following ablative ...
Shuangshuang Zhao +7 more
wiley +1 more source
Deficiency for scavenger receptors Stabilin-1 and Stabilin-2 leads to age-dependent renal and hepatic depositions of fasciclin domain proteins TGFBI and Periostin in mice. [PDF]
Aging Cell, 2023 Leibing T +9 more
europepmc +1 more source
Scavenger receptor-mediated recognition of maleyl bovine plasma albumin and the demaleylated protein in human monocyte macrophages. [PDF]
, 1985 M E Haberland, A M Fogelman
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