Results 41 to 50 of about 12,304 (281)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The characterization of volatile floral scent in Phalaenopsis-type Dendrobium hybrids

Ornamental Plant Research
Phalaenopsis-type Dendrobium hybrids (den-phals) are globally important ornamental plants. Aromatic commercial den-phals are rare, but the fragrance of their flowers has gradually become a significant trait influencing consumer preferences. In this study,
Xiting Yang, Junmei Yin, Shunjiao Lu, Yi Liao, Riru Zheng, Chonghui Li   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Olfaktoryczna przyszłość kina — technologie zapachowe i świat filmu

Studia Filmoznawcze
The article is devoted to the potential of olfactory technologies in contemporary film. Attempts to interject the cinema and scents are known to be a disastrous history of failed experiments like Smell-O-Vision, but cinema and streaming platforms are ...
Marta Snoch
doaj   +1 more source

Assessment of predation risk through conspecific alarm odors by spiny lobsters How much is too much?

Communicative & Integrative Biology, 2009
Strong “alarm odors” emanating from lethally injured conspecifics may indicate an imminent risk of predation to spiny lobsters. In laboratory trials,1 strong conspecific alarm odors elicited avoidance in Panulirus argus, a highly gregarious species that ...
Patricia Briones-Fourzán
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Neuroestetyka zapachu: o wyzwaniach i ograniczeniach sztuki olfaktorycznej

Analiza i Egzystencja
The article analyzes philosophical problems related to olfactory art, which, despite the historical marginalization of this sense as “lower,” “dark,” or “animalistic,” is increasingly asserting its presence in aesthetic discourse.
Anna Prus
doaj   +1 more source

Nocturnal Bee Pollinators Are Attracted to Guarana Flowers by Their Scents

Frontiers in Plant Science, 2018
Floral scent is an important component of the trait repertoire of flowering plants, which is used to attract and manipulate pollinators. Despite advances during the last decades about the chemicals released by flowers, there is still a large gap in our ...
Cristiane Krug, Guaraci D. Cordeiro, Irmgard Schäffler, Claudia I. Silva, Reisla Oliveira, Clemens Schlindwein, Stefan Dötterl, Isabel Alves-dos-Santos   +7 more
doaj   +1 more source