Results 131 to 140 of about 59,530 (304)

Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial

Scientific Reports, 2017
Short-chain fatty acids (SCFA), formed by microbial fermentation, are believed to be involved in the aetiology of obesity and diabetes. This study investigated the effects of colonic administration of physiologically relevant SCFA mixtures on human ...
Emanuel E. Canfora, Christina M. van der Beek, Johan W. E. Jocken, Gijs H. Goossens, Jens J. Holst, Steven W. M. Olde Damink, Kaatje Lenaerts, Cornelis H. C. Dejong, Ellen E. Blaak   +8 more
doaj   +1 more source

Gut microbiota-derived SCFAs and MetS-related nephropathy

Frontiers in Nutrition
Metabolic syndrome (MetS) is a group of complex disorders characterized by abnormalities in the metabolism of proteins, fats, carbohydrates, and other substances in the human body. The kidney plays a vital role in these metabolic processes. Similarly, metabolic disorders can lead to renal damage, which can affect both its structure and function.
Xiaofang Tian, Li Sun, Shengjie Guo, Liying Yuan, Tang Zhang, Chengqian Huang, Tingting He, Qianfeng Jiang, Yizhou Zeng   +8 more
openaire   +2 more sources

Interkingdom Interactions in the Gut: Ecological Mechanisms, Homeostasis, and Therapeutic Modulation

Gut Medicine, EarlyView.
ABSTRACT The gut microbiota constitutes a highly complex and dynamic ecosystem that profoundly influences host physiology, metabolism, and immunity. This review provides an integrative overview of the mechanisms through which gut microorganisms—particularly bacteria and fungi—interact with host cells and with each other to maintain intestinal ...
Rui‐Qi Wei, Xin‐Wei Sun, Hao‐Jie Huang, Yu‐Zhi Zhao, Shuang‐Jiang Liu, Chang Liu   +5 more
wiley   +1 more source

SCFA Revisited [PDF]

Meta: Journal des traducteurs, 1983
openaire   +1 more source

SCFA biotherapy delays diabetes in humanized gnotobiotic mice by remodeling mucosal homeostasis and metabolome

Nature Communications
Type 1 diabetes (T1D) is linked to an altered gut microbiota characterized by reduced short-chain fatty acid (SCFA) production. Oral delivery of a SCFA-yielding biotherapy in adults with T1D was followed by increased SCFAs, altered gut microbiota and ...
Bree J. Tillett, Jacky Dwiyanto, Kate R. Secombe, Thomas George, Vivian Zhang, Dovile Anderson, Emily Duggan, Rabina Giri, Dorothy Loo, Thomas Stoll, Mark Morrison, Jakob Begun, Michelle M. Hill, Esteban N. Gurzov, Kirstine J. Bell, Sonia Saad, Christopher K. Barlow, Darren J. Creek, Chun Wie Chong, Eliana Mariño, Emma E. Hamilton-Williams   +20 more
doaj   +1 more source

Effects of single-dose ruminal infusions of high or low short-chain fatty acid concentrations and high or low pH on apparent total-tract digestibility and hindgut fermentation of preweaning dairy calves

Journal of Dairy Science
: Although the importance of pH and short-chain fatty acids (SCFA) on rumen development are well-known, their impact on the small and large intestine are unclear.
M.H.P.M. Narciso, A.R. Wolfe, R.R.E. Uwiera, A.H. Laarman   +3 more
doaj   +1 more source

Oat β‐Glucan and Galactooligosaccharides Influence Gallstone Formation by Modulating the Gut Microbiota, Particularly Desulfovibrionales

iMetaMed, EarlyView.
Oat β‐glucan and galactooligosaccharides influence the formation of gallstones by modulating the gut microbiota, particularly the abundance of Desulfovibrionales. The primary mechanism involves metabolic byproducts associated with Desulfovibrionales inhibiting hepatic bile acid synthesis via both the hepatic FXR–SHP and intestinal FXR–FGF15 signaling ...
Liang Tian, Yanyan Lin, Ping Yue, Long Gao, Leiqing Wang, Chongfei Huang, Jinyu Zhao, Ningzu Jiang, Jiahui xi, Haidong Ma, Zhen Liu, Ruyang Zhong, Wenkang Fu, Ningning Mi, Mingzhen Bai, Bodong Zhang, Lunzhi Dai, Jiang Li, Hu Chen, Jinqiu Yuan, Wenbo Meng   +20 more
wiley   +1 more source

The application of fatty acid-monoglyceride blend to modulate morphology and biochemical blood parameters of broiler chickens

Theoretical and Applied Veterinary Medicine
Blends of organic acids with monoglycerides are considered as promising tools for the development of alternative strategies to support the health of productive animals.
L. M. Tamchuk, D. M. Masiuk
doaj   +1 more source

The gut microbiota-SCFA-inflammation axis in patients with AECOPD

PLOS ONE
Objectives The aim of the study was to explore the alteration of microbiota and SCFA in gut and inflammation in acute exacerbation chronic obstructive pulmonary disease (AECOPD) patients, and to test the hypothesis that a disorder of gut microbiota will lead to the alteration of SCFA, which will aggravate inflammation in AECOPD patients. Methods and
Hengjing Zhu, Chen Wu, Haiyan Wu, Juan Liu, Wu Ye, Tian Zhao, Zhijun Li   +6 more
openaire   +2 more sources

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, EarlyView.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source