Results 101 to 110 of about 1,347,718 (326)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

The Aircraft Landing Problem

open access: yesCommunications, 2003
The problem studied in the paper is an air traffic problem on the airport runway. The goal is finding an aircraft landing sequence that meets the time window for the particular aircraft and at the same time the separation times between two aircraft ...
Jan Pelikan
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Improving the job shop scheduling algorithm to minimize total penalty costs considering maintenance activity

open access: yesOPSI
Production scheduling is generally based on the assumption that resources are always available. In reality, these resources, machines, and supporting facilities experience limited availability due to interruptions during the production process. Therefore,
Puryani Puryani   +4 more
doaj   +1 more source

Mathematical Programming vs. Constraint Programming for Scheduling Problems

open access: yesCommunications, 2013
This paper focuses on a classical scheduling problem known as the job-shop scheduling problem which is one of the most difficult problems in combinatorial optimisation.
Ludmila Janosikova, Tomas Hreben
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

On Optimal Weighted-Delay Scheduling in Input-Queued Switches

open access: yes, 2017
Motivated by relatively few delay-optimal scheduling results, in comparison to results on throughput optimality, we investigate an input-queued switch scheduling problem in which the objective is to minimize a linear function of the queue-length vector ...
Lu, Yingdong   +3 more
core  

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