Results 111 to 120 of about 1,075,802 (276)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Systems Developmental Dependency Analysis for Scheduling Decision Support: The Lunar Gateway Case Study

Systems
Project Managers face many difficulties when scheduling the development and production of multiple, largely independent systems required for a new capability, especially when there are multiple stakeholders, uncertainties in the expected development time,
Cesare Guariniello, Daniel DeLaurentis
doaj   +1 more source

Efficient Work Team Scheduling: Using Psychological Models of Knowledge Retention to Improve Code Writing Efficiency [PDF]

Journal of Systemics, Cybernetics and Informatics, 2014
Development teams and programmers must retain critical information about their work during work intervals and gaps in order to improve future performance when work resumes.
Michael J. Pelosi, Michael Scott Brown, Henry Dirska, Mir Mohammed Assadullah   +3 more
doaj  

On Optimal Weighted-Delay Scheduling in Input-Queued Switches

, 2017
Motivated by relatively few delay-optimal scheduling results, in comparison to results on throughput optimality, we investigate an input-queued switch scheduling problem in which the objective is to minimize a linear function of the queue-length vector ...
Lu, Yingdong, Maguluri, Siva Theja, Squillante, Mark S., Suk, Tonghoon   +3 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Bulk Scheduling with DIANA Scheduler

, 2006
Results from and progress on the development of a Data Intensive and Network Aware (DIANA) Scheduling engine, primarily for data intensive sciences such as physics analysis, are described. Scientific analysis tasks can involve thousands of computing, data handling, and network resources and the size of the input and output files and the amount of ...
Anjum, Ashiq, McClatchey, Richard, Ali, Arshad, Willers, Ian   +3 more
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Crowding distance and IGD-driven grey wolf reinforcement learning approach for multi-objective agile earth observation satellite scheduling

International Journal of Digital Earth
With the rise of low-cost launches, miniaturized space technology, and commercialization, the cost of space missions has dropped, leading to a surge in flexible Earth observation satellites.
He Wang, Weiquan Huang, Sindri Magnússon, Tony Lindgren, Chen Chen, Junyu Wu, Yanjie Song   +6 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source