Results 81 to 90 of about 1,304,220 (323)

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

A Multi Period Routing and Scheduling optimization Model for Home health Care Problem [PDF]

Muṭāli̒āt-i Mudīriyyat-i Ṣan̒atī, 2018
Home health care services have a key importance in modern societies. Most organizations working in this area in Iran use the traditional procedure to plan and manage medical staff and determine the arrangement of visiting patients.
Seyed Mohammad Taghi Fatemi Ghomi, Ehsan Arabzadeh, Behrooz Karimi   +2 more
doaj   +1 more source

Joint Scheduling and ARQ for MU-MIMO Downlink in the Presence of Inter-Cell Interference

, 2010
User scheduling and multiuser multi-antenna (MU-MIMO) transmission are at the core of high rate data-oriented downlink schemes of the next-generation of cellular systems (e.g., LTE-Advanced). Scheduling selects groups of users according to their channels
Caire, Giuseppe, Papadopoulos, Haralabos C., Ramprashad, Sean A., Shirani-Mehr, Hooman   +3 more
core   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Hybrid Scheduling/Signal-Level Coordination in the Downlink of Multi-Cloud Radio-Access Networks

, 2015
In the context of resource allocation in cloud-radio access networks, recent studies assume either signal-level or scheduling-level coordination. This paper, instead, considers a hybrid level of coordination for the scheduling problem in the downlink of ...
Al-Naffouri, Tareq Y., Alouini, Mohamed-Slim, Dahrouj, Hayssam, Douik, Ahmed   +3 more
core   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

A Novel Auction-Based Truck Appointment System for Marine Terminals

Logistics
Background: Increased maritime trade has led to a surge in drayage operations, causing congestion and environmental issues in port areas. Truck Appointment Systems (TASs) are commonly used to manage truck arrival rates, yet transparency and equity in ...
Ilias Alexandros Parmaksizoglou, Alessandro Bombelli, Alexei Sharpanskykh   +2 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Augmented ɛ‐constraint‐based matheuristic methodology for Bi‐objective production scheduling problems

IET Collaborative Intelligent Manufacturing
Matheuristic is an optimisation methodology that integrates mathematical approaches and heuristics to address intractable combinatorial optimisation problems, where a common framework is to insert mixed integer linear programming (MILP) models as local ...
Jiaxin Fan
doaj   +1 more source

The Impact of Mobile-Based Calendar Applications for Digitalizing Scheduling Management on Community Participation and Awareness in Traditional Villages

Jurnal Ilmiah Manajemen dan Bisnis
This study aims to investigate the impact of implementing a mobile-based scheduling information system in the Desa Adat Tuban. The research focuses on enhancing information services provided by village officials, as well as increasing community ...
Luh Nik Oktarini, I Kadek Andy Asmarajaya   +1 more
doaj   +1 more source