We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti+2 more
wiley +1 more source
Evaluating performance of production scheduling from an economic perspective [PDF]
Production scheduling which is a part of the planning and control of production units lies at the heart of the performance of manufacturing organizations. Production scheduling determines organizational performance.
Mapokgole, Johannes
core +1 more source
The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang+9 more
wiley +1 more source
Concepts and Algorithms for Agent-based Decentralized and Integrated Scheduling of Production and Auxiliary Processes [PDF]
Individualized products and shorter product life cycles have driven companies to rethink traditional mass production. New concepts like Industry 4.0 foster the advent of decentralized production control and distribution of information. A promising technology for realizing such scenarios are Multi-agent systems.
arxiv
Rancang Bangun Sistem Penjadwalan Produksi dengan Menggunakan Metode Earliest Due Date pada CV Tidar Jaya [PDF]
Production scheduling is one of the most important aspect that ensures the business process of a company running smoothly, as well as in CV Tidar Jaya. CV Tidar Jaya in its business has not utilized any production scheduling schemes, it can be seen from ...
Hananto, V. R. (Valentinus)+2 more
core
Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka+6 more
wiley +1 more source
Robust Order Scheduling in the Fashion Industry: A Multi-Objective Optimization Approach [PDF]
In the fashion industry, order scheduling focuses on the assignment of production orders to appropriate production lines. In reality, before a new order can be put into production, a series of activities known as pre-production events need to be completed.
arxiv
Job Shop Scheduling via Deep Reinforcement Learning: a Sequence to Sequence approach [PDF]
Job scheduling is a well-known Combinatorial Optimization problem with endless applications. Well planned schedules bring many benefits in the context of automated systems: among others, they limit production costs and waste. Nevertheless, the NP-hardness of this problem makes it essential to use heuristics whose design is difficult, requires ...
arxiv
In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri+8 more
wiley +1 more source
Scheduling for Flexible Manufacturing System with Objective Function to be Minimization of Total Processing Time and Unbalance of Machine Load [PDF]
For scheduling in flexible manufacturing system (FMS), many factors should be considered, it is difficult to solve the scheduling problem by satisfying different criteria (production cost, utilization of system, number of movements of part, make-span, and tardiness in due date and so on) and constrains.
arxiv