Results 121 to 130 of about 775,681 (328)

Autophagy in cancer and protein conformational disorders

open access: yesFEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Heat Integration of Material Transfer Streams in Batch Processing Plants

open access: yesChemical Engineering Transactions, 2015
Batch processes are flexible allowing the production of different products within the same facility, and suitable for producing low volume, high value-added products such as pharmaceuticals and agrochemicals.
J.-Y. Lee, E.R. Seid, M. Majozi
doaj   +1 more source

Time-interval balancing in multi-processor scheduling of composite modular jobs (preliminary description) [PDF]

open access: yesarXiv, 2018
The article describes a special time-interval balancing in multi-processor scheduling of composite modular jobs. This scheduling problem is close to just-in-time planning approach. First, brief literature surveys are presented on just-in-time scheduling and due-data/due-window scheduling problems.
arxiv  

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

A mathematical model for simultaneous personnel shift planning and unrelated parallel machine scheduling [PDF]

open access: yesarXiv
This paper addresses a production scheduling problem derived from an industrial use case, focusing on unrelated parallel machine scheduling with the personnel availability constraint. The proposed model optimizes the production plan over a multi-period scheduling horizon, accommodating variations in personnel shift hours within each time period.
arxiv  

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

Datasets for lot sizing and scheduling problems in the fruit-based beverage production process

open access: yesData in Brief, 2021
The datasets presented here were partially used in “Formulation and MIP-heuristics for the lot sizing and scheduling problem with temporal cleanings” (Toscano, A.,  Ferreira, D., Morabito, R., Computers & Chemical Engineering) [1], in “A ...
Juan Piñeros   +3 more
doaj  

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

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