Results 91 to 100 of about 3,861,665 (292)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Cognitive science and epistemic openness [PDF]

open access: yes, 2005
Recent findings in cognitive science suggest that the epistemic subject is more complex and epistemically porous than is generally pictured. Human knowers are open to the world via multiple channels, each operating for particular purposes and according ...
Anderson, Dr. Michael L.
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Evaluation of Relationship between Schemas and Panic Disorder through a Case Treated with Schema Therapy

open access: yesBilişsel Davranışçı Psikoterapi ve Araştırmalar Dergisi, 2014
Introduction: Schema therapy (ST) is a form psychoterapy combining existential, cognitive-behavioral, psychodynamic and object relation techniques that was developed by Jeffrey Young for personality disorders and severe behavioral pathology which are ...
Esra Yancar Demir, Gonca Soygüt
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Comparison of Schema Modes in Clinical and Non-Clinical Individuals: A Preliminary Finding

open access: yes, 2020
This study compares the schema modes between the clinical and non-clinical individuals. A purposive convenient sampling technique was used for the data collection from one hundred and fifty healthy community volunteers, and sixty diagnosed psychiatric ...
Meh Para Siddique, Rubina Hanif
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Comparing the efficacy of cognitive-behavioral therapy with the treatment of allegorical schema modes on psychotherapists burnout [PDF]

open access: yesمجله علوم روانشناختی, 2023
Background: Job burnout is one of the psychological problems that threaten therapists. This problem can lead to a decrease in service quality. Cognitive-behavioral therapy and paradigmatic schema mentalities therapy are two intervention methods that have
Mohammad Faghanpour ganji   +2 more
doaj  

Asynchronous data retrieval from an object-oriented database [PDF]

open access: yes, 1988
We present an object-oriented semantic database model which, similar to other object-oriented systems, combines the virtues of four concepts: the functional data model, a property inheritance hierarchy, abstract data types and message-driven computation.
Bic, Lubomir, Gilbert, Jonathan P.
core  

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