Results 91 to 100 of about 152,563 (267)

Dysfunctional schema modes in individuals with frontal lobe lesion; multiple CASE study analysis

Interdisciplinary Neurosurgery, 2019
Objectives: This study aimed to investigate the emotional, cognitive and behavioural responses of individuals with frontal lobe lesions. The study also sought to determine the coping and defence responses, as well as the executive functioning and higher ...
Sabir Zaman, Kehkashan Arouj, Dr., Shahid Irfan, Dr.   +2 more
doaj   +1 more source

Enhancing the EAST-ADL error model with HiP-HOPS semantics [PDF]

, 2014
EAST-ADL is a domain-specific modelling language for the engineering of automotive embedded systems. The language has abstractions that enable engineers to capture a variety of information about design in the course of the lifecycle — from requirements ...
Chen, De-Jiu, Lönn, Henrik, Papadopoulos, Yiannis, Sharvia, Septavera, Walker, Martin, Yuan, Wenjing   +5 more
core  

TEMPOS: A Platform for Developing Temporal Applications on Top of Object DBMS [PDF]

, 2004
This paper presents TEMPOS: a set of models and languages supporting the manipulation of temporal data on top of object DBMS. The proposed models exploit object-oriented technology to meet some important, yet traditionally neglected design criteria ...
Dumas Menjivar, Marlon, Fauvet, Marie-Christine, Scholl, Pierre-Claude   +2 more
core   +3 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The effectiveness of individual schema therapy in older adults with borderline personality disorder: Protocol of a multiple-baseline study

Contemporary Clinical Trials Communications, 2019
Background: The treatment of borderline personality disorder (BPD) has been examined extensively in adults up to the age of fifty in the past quarter of a century, but there is still a world to discover in treating BPD in older adults.
D.A. Khasho, S.P.J. van Alphen, S.M.J. Heijnen-Kohl, M.A. Ouwens, A. Arntz, A.C. Videler   +5 more
doaj   +1 more source

Automatic Verification of Transactions on an Object-Oriented Database [PDF]

, 1997
In the context of the object-oriented data model, a compiletime approach is given that provides for a significant reduction of the amount of run-time transaction overhead due to integrity constraint checking.
Balsters, H., Spelt, D.
core   +4 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Short Communication: The need for open-source hardware, software, and data-sharing specifications in geomorphology [PDF]

Earth Surface Dynamics
Geomorphologists have more data and computational resources available than ever before. Collaboration between researchers specializing in different modes of inquiry (e.g.
A. J. Moodie, E. Barefoot, E. Hutton, C. Nguyen, A. D. Wickert, A. D. Wickert, J. Marr   +6 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source