Results 71 to 80 of about 15,657 (202)

microRNAs of parasitic helminths – identification, characterization and potential as drug targets [PDF]

, 2014
microRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation. They were first identified in the free-living nematode Caenorhabditis elegans, where the miRNAs lin-4 and let-7 were shown to be essential for regulating ...
Britton, Collette, Devaney, Eileen, Gillan, Victoria, Winter, Alan D.   +3 more
core   +1 more source

Synthesis of 1,2,3‐Triazole‐Methyl‐Menadione Derivatives: Evaluation of Electrochemical and Antiparasitic Properties against two Blood‐Dwelling Parasites

ChemMedChem, Volume 20, Issue 6, March 15, 2025.
The present study describes the synthesis and thorough investigation of 1,2,3‐triazole‐methyl‐menadione derivatives with particular emphasis on their electrochemical and physicochemical properties and their antiparasitic activities against Plasmodium falciparum and Schistosoma mansoni. Although less effective against P.
Baptiste Dupouy, Tanja Karpstein, Cécile Häberli, Monica Cal, Matthias Rottmann, Pascal Mäser, Jennifer Keiser, Mourad Elhabiri, Elisabeth Davioud‐Charvet   +8 more
wiley   +1 more source

Asian Schistosomiasis: Current Status and Prospects for Control Leading to Elimination

Tropical Medicine and Infectious Disease, 2019
Schistosomiasis is an infectious disease caused by helminth parasites of the genus Schistosoma. Worldwide, an estimated 250 million people are infected with these parasites with the majority of cases occurring in sub-Saharan Africa.
Catherine A. Gordon, Johanna Kurscheid, Gail M. Williams, Archie C. A. Clements, Yuesheng Li, Xiao-Nong Zhou, Jürg Utzinger, Donald P. McManus, Darren J. Gray   +8 more
doaj   +1 more source

Fragment-based discovery of a regulatory site in thioredoxin glutathione reductase acting as "doorstop" for NADPH entry [PDF]

, 2018
Members of the FAD/NAD-linked reductase family are recognized as crucial targets in drug development for cancers, inflammatory disorders, and infectious diseases.
Angelucci, Francesco, Ardini, Matteo, Arner, Elias S. J., Bellelli, Andrea, Boumis, Giovanna, Chen, Qing, Fata, Francesca, Ippoliti, Rodolfo, Jadhav, Ajit, Lea, Wendy A., Lyu, Haining, Miele, Adriana E., Petukhov, Pavel A., Silvestri, Ilaria, Simeonov, Anton, Thatcher, Gregory R. J., Williams, David L.   +16 more
core   +3 more sources

Phytotherapy for Liver Fibrosis: Insights From the Biology of Hepatic Stellate Cells—A Narrative Review

Liver International Communications, Volume 6, Issue 1, March 2025.
ABSTRACT Chronic liver diseases frequently progress to liver fibrosis, characterized by the accumulation of extracellular matrix (ECM) proteins and the formation of fibrous scars. This fibrous tissue disrupts normal liver architecture, impairing its physiological functions.
Sathish Kumar Mungamuri, Nabanita Chatterjee, Dilkash Ara   +2 more
wiley   +1 more source

The History of Schistosomiasis Japonica in Taiwan

Kaohsiung Journal of Medical Sciences, 2006
Studies of schistosomiasis japonica in Taiwan indicate that the Formosan strain of Schistosoma japonicum is zoophilic in nature. After the discovery of the adult worm of S.
Ping-Chin Fan
doaj   +1 more source

Targeting Fibrosis: From Molecular Mechanisms to Advanced Therapies

Advanced Science, Volume 12, Issue 3, January 20, 2025.
This review comprehensively summarizes the advances in research for fibrosis. It emphasizes organ‐specific profibrotic cell types and molecular mechanisms of fibrosis, especially in the kidney, liver, lung, and heart. The authors highlight the advanced antifibrotic small molecule drugs and cellular therapies for fibrosis.
Xingpeng Di, Ya Li, Jingwen Wei, Tianyue Li, Banghua Liao   +4 more
wiley   +1 more source

Vaccines against the zoonotic trematodes Schistosoma japonicum, Fasciola hepatica and Fasciola gigantica [PDF]

, 2006
Schistosoma japonicum, Fasciola hepatica and F. gigantica are digenetic trematodes and, therefore, possess similar life cycles. While schistosomiasis japonica has for a long time been recognised as a major disease of both humans and animals, infection ...
Dalton, JP, McManus, DP
core   +1 more source

Schistosoma japonicum infection induces macrophage polarization [PDF]

The Journal of Biomedical Research, 2014
The role of macrophages (Mφ) as the first line of host defense is well accepted. These cells play a central role in orchestrating crucial functions during schistosomal infection. Thus, understanding the functional diversity of these cells in the process of infection as well as the mechanisms underlying these events is crucial for developing disease ...
Donghui Zhang, Jingwei Xu, Hao Zhang, Guanling Wu, Hai-Wei Wu, Lin Chen, Minjun Ji   +6 more
openaire   +3 more sources

Tissue‐resident memory T cells in diseases and therapeutic strategies

MedComm, Volume 6, Issue 1, January 2025.
Tissue‐resident memory T (TRM) cells are crucial components of the immune system and play vital roles in antiviral, antibacterial, and antitumor immunity, as well as chronic inflammation conditions and graft‐versus‐host diseases. Understanding the intricate regulation of TRM cells is crucial for developing targeted therapeutic strategies, such as ...
Daoyuan Xie, Guanting Lu, Gang Mai, Qiuyan Guo, Guofeng Xu   +4 more
wiley   +1 more source