Results 41 to 50 of about 44,135 (156)

Glabralysins, potential New β-pore-forming toxin family members from the schistosomiasis vector snail biomphalaria glabrata [PDF]

, 2020
Biomphalaria glabrata is a freshwater Planorbidae snail. In its environment, this mollusk faces numerous microorganisms or pathogens, and has developed sophisticated innate immune mechanisms to survive.
Crickmore, Neil, Duval, David, Galinier, Richard, Gourbal, Benjamin, Lassalle, Damien, Pinaud, Silvain, Tetreau, Guillaume   +6 more
core   +2 more sources

Identification of training needs in schistosomiasis research to build capacity for schistosomiasis control in Uganda

Tropical Medicine &International Health, Volume 30, Issue 4, Page 314-321, April 2025.
Abstract Background Schistosomiasis is the leading cause of fatal upper gastrointestinal bleeding among adults in East Africa. The prevalence among school‐aged children in villages along the Albert–Nile shoreline in North‐Western Uganda is estimated at 85%.
Damalie Nakanjako, Moses Egesa, Helen Byakwaga, Casim Umba Tolo, Anatol Maranda Byaruhanga, Prudence Beinamaryo, Grace Banturaki, Lydia Nakiyingi, Ponsiano Ocama, Moses R. Kamya, Alison M. Elliott   +10 more
wiley   +1 more source

Co‐endemicity of schistosomiasis and tegumentary leishmaniasis: Spatial co‐clustering in endemic areas

Tropical Medicine &International Health, EarlyView.
Abstract Objectives Schistosomiasis and tegumentary leishmaniasis simultaneously affect areas in tropical and subtropical regions. Co‐infected individuals show a less‐than‐optimal response to treatment and increased regulatory immune responses. However, no study has determined where Schistosoma–Leishmania co‐infections are more likely to occur ...
Genil Mororó Araújo Camelo, Jeferson Kelvin Alves de Oliveira Silva, Dharliton Soares Gomes, Laura Maggi, Stefan Michael Geiger, David Soeiro Barbosa, Deborah Aparecida Negrão‐Corrêa   +6 more
wiley   +1 more source

Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert, Lucie Paloque, Jean‐Michel Augereau, Flore Nardella, Michel Nguyen, Bernard Meunier, Françoise Benoit‐Vical   +6 more
wiley   +1 more source

Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni) [PDF]

, 2010
Here, we observed the uptake of membrane-impermeant molecules by cercariae as they penetrate the skin and are transformed into schistosomula. We propose that membrane-impermeant molecules, Lucifer Yellow, Propidium iodide and Hoechst 33258 enter the ...
Alvisi de Oliviera, Fabricia, Coelho, Paulo Marcos Zech, Kusel, John, Lima, Symone Fulgêncio, Mattos, Ana Carolina Alves, McVeigh, Paul, Ribeiro, Fabio, Thornhill, Joyce   +7 more
core   +4 more sources

Bacterial Outer Membrane Vesicles: From Physics to Clinical

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
A review of an introduction to the mechanisms of formation of OMVs, their action on bacteria and relationship to disease, vaccines, biomonitoring, drug delivery and regenerative medicine in the clinic. ABSTRACT Bacterial outer membrane vesicles (OMVs) are nanoscale vesicular structures naturally produced by Gram‐negative bacteria during growth.
Jun Zhou, Shuang Zou, Derong Dai, Liqing He, Xingyu Mou, Ninglin Zhao, Hong Li, Rui Bao   +7 more
wiley   +1 more source

Critical Role of Skin in Pathogenesis: Bidirectional Crosstalk Between Skin and Multiple Organs

MedComm – Future Medicine, Volume 4, Issue 2, June 2025.
The skin functions as both a protective barrier and an autonomous immune organ, maintaining dynamic interactions with internal organs. This review analyzes skin‐organ crosstalk mechanisms, highlighting key cytokines (particularly IL‐17A) and microbial metabolites that mediate interorgan communication.
Wende Deng, Junyi Liu, Changheng Tang, Zhenghao Li, Ying Qiu, Han Zhou, Lanxuan Yang, Ting Li   +7 more
wiley   +1 more source

Myeloradiculopathy associated to Schistosoma mansoni [PDF]

Case Reports, 2011
Neuroschistosomiasis caused by Schistosoma mansoni (Sm) is a rare and severe condition potentially leading to permanent neurological deficit. An 18-year-old Brazilian female was admitted due to a severe conus medullaris and cauda equina syndrome. MRI of thoracic/lumbar spine showed an expanded conus medullaris with patchy gadolinium-enhancement, needle
Carolina Santos, Ruth Geraldes, Miguel Coelho, Maria Grácio, Mário M. Rosa, João Lobo Antunes, Patrícia Pita Lobo   +6 more
openaire   +3 more sources

Diagnosis of \u3cem\u3eSchistosoma mansoni\u3c/em\u3e without the Stool: Comparison of Three Diagnostic Tests to Detect \u3cem\u3eSchiostosoma mansoni\u3c/em\u3e Infection from Filtered Urine in Zambia [PDF]

, 2013
Diagnosis for intestinal Schistosoma mansoni lacks sensitivity and is arduous to conduct. The standard diagnostic tests, Kato-Katz (KK) and circulating cathodic antigen (CCA) both lack sensitivity and with KK, require obtaining, transporting, and ...
Lodh, Nilanjan, Mutengo, Mabel M., Mwansa, James C. L., Shiff, Clive J.   +3 more
core   +1 more source

Enhancing schistosomiasis drug discovery approaches with optimized proteasome substrates

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Schistosomiasis, a neglected tropical disease infecting over 200 million people globally, has limited therapeutic options. The 20S proteasome is a validated drug target for many parasitic infections, including those caused by Plasmodium and Leishmania, and we have previously demonstrated antischistosomal activity with inhibitors targeting ...
Elany B. Silva, Zhenze Jiang, Chenxi Liu, Pavla Fajtová, Thaiz R. Teixeira, Giovana de Castro Fiorini Maia, Lawrence J. Liu, Nelly El‐Sakkary, Danielle E. Skinner, Ali Syed, Steven C Wang, Conor R. Caffrey, Anthony J. O'Donoghue   +12 more
wiley   +1 more source