Results 81 to 90 of about 98,465 (295)

Prevalence and Predictors Associated to Schistosoma mansoni Infection among Patients Attending the Saint Jean de Malte Hospital, Njombe, Littoral Region, Cameroon

Journal of Parasitology Research, 2023
Background. Schistosomiasis remains a major public health concern in sub-Saharan Africa. It has been associated to morbidity and mortality in developing countries including Cameroon, and Njombe-Penja health district is an endemic area.
Ambe Fabrice Ngwa, Pride Tanyi Bobga, Ekwi Damian Nsongmayi, Gedeon Schadrack Yememe Yememe, Judith Ngong Nyeme, Mohamed Isah, Ebai Christabel Ashu, Calvin Bisong Ebai   +7 more
doaj   +1 more source

A Persistent Hotspot of Schistosoma mansoni Infection in a Five-Year Randomized Trial of Praziquantel Preventative Chemotherapy Strategies

Journal of Infectious Diseases, 2017
During a trial of preventive chemotherapy strategies, a hotspot of Schistosoma mansoni infection was found. Significant differences between hotspot and nonhotspot villages were found after 1 year.
Ryan E. Wiegand, Pauline N. M. Mwinzi, Susan P. Montgomery, YuYen L Chan, Kennedy Andiego, Martin Omedo, G. Muchiri, M. Ogutu, Fredrick Rawago, M. Odiere, D. Karanja, W. Secor   +11 more
semanticscholar   +1 more source

In the absence of CD154, administration of interleukin-12 restores Th1 responses but not protective immunity to Schistosoma mansoni [PDF]

, 2007
The cytokine interplay during the development of protective immunity to the radiation-attenuated (RA) schistosome vaccine has been extensively characterized over recent years, yet the role of costimulatory molecules in the development of cell-mediated ...
Hamblin, Paul A, Hewitson, James P, Mountford, Adrian P   +2 more
core   +2 more sources

Identification of β‐galactosidases along the secretory pathway of Nicotiana benthamiana that collectively hamper engineering of galactose‐extended glycans on recombinant glycoproteins

Plant Biotechnology Journal, EarlyView.
Summary Glycosylation is an important aspect for many biopharmaceuticals, including vaccines against parasitic helminths. Plants, especially Nicotiana benthamiana, have proven to be excellent production hosts for biopharmaceuticals with tailor‐made glycosylation.
Alex van der Kaaij, Myrna J. M. Bunte, Lisa Nijhof, Sanaz Mokhtari, Hein Overmars, Arjen Schots, Ruud H. P. Wilbers, Pieter Nibbering   +7 more
wiley   +1 more source

Under diagnosis of intestinal schistosomiasis in a referral hospital, North Ethiopia

BMC Research Notes, 2018
Objective The present cross-sectional study was aimed at determining the magnitude of under diagnosis of intestinal schistosomiasis among patients requested for routine ova/parasite examination at Ayder referral hospital.
Megbaru Alemu, Eyob Zigta, Awoke Derbie
doaj   +1 more source

Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection

Scientific Reports, 2016
Schistosoma mansoni is a parasitic fluke that infects millions of people in the developing world. This study presents the first application of population genomics to S.
Thomas Crellen, F. Allan, S. David, C. Durrant, Thomas Huckvale, N. Holroyd, A. Emery, D. Rollinson, D. Aanensen, M. Berriman, J. Webster, J. Cotton   +11 more
semanticscholar   +1 more source

Hepatic stellate cells and parasite-induced liver fibrosis [PDF]

, 2010
: Fibrogenesis is a common feature of many diseases where there is severe insult to the liver. The hepatic stellate cell trans-differentiation into a myofibroblast has been identified as an important event in liver fibrogenesis and has been well ...
Allen, JT, Anthony, BJ, Li, YS, McManus, DP   +3 more
core   +2 more sources

Fucosyltransferases in Schistosoma mansoni development [PDF]

Glycobiology, 2001
Glycoconjugate-bound fucose, abundant in the parasite Schistosoma mansoni, has been found in the form of Fucalpha1,3GlcNAc, Fucalpha1,2Fuc, Fucalpha1,6GlcNAc, and perhaps Fucalpha1,4GlcNAc linkages. Here we quantify fucosyltransferase activities in three developmental stages of S. mansoni.
Mette Strand, Yoshitaka Ichikawa, J. T. August, Ronald L. Schnaar, Ernesto T. A. Marques, Gerald W. Hart   +5 more
openaire   +3 more sources

Highly efficient transgene‐free ErCas12a RNP‐protoplast genome editing and single‐cell regeneration in Nicotiana benthamiana for glyco‐engineering

Plant Biotechnology Journal, EarlyView.
Summary Nicotiana benthamiana serves as a unique platform for biopharmaceutical production, offering advantages such as efficient and scalable protein synthesis. In addition, custom N‐glycans can be engineered on biopharmaceutical glycoproteins. Yet, plant‐native glycosyltransferases and glycoside hydrolases need to be removed to prevent undesired ...
Lukas C. Blumberg, Geartsje M. Bakker, Alex van der Kaaij, Élyse Gariépy, Henri van de Geest, Erik J. Slootweg, Ferdinand C. O. Los, Lotte B. Westerhof, Ruud H. P. Wilbers   +8 more
wiley   +1 more source

Seleção genética de Biomphalaria glabrata e Biomphalaria tenagophila visando a alteração da suscetibilidade e resistência ao Schistosoma mansoni Genetic selection of Biomphalaria glabrata and Biomphalaria tenagophila seeking the alteration of the susceptibility and resistance to the Schistosoma mansoni

Revista da Sociedade Brasileira de Medicina Tropical, 2005
Gerações de Biomphalaria glabrata e Biomphalaria tenagophila selecionadas geneticamente para resistência e suscetibilidade ao Schistosoma mansoni das linhagens BH e SJ foram utilizadas no estudo da adaptação do trematódeo ao hospedeiro intermediário.
Nádia Regina Borim Zuim, Eliana Maria Zanotti-Magalhães, Luiz Augusto Magalhães, Arício Xavier Linhares   +3 more
doaj   +1 more source