Results 31 to 40 of about 46,909 (203)

Inhibitory effects of 19 antiprotozoal drugs and antibiotics on Babesia microti infection in BALB/c mice

open access: yesJournal of Infection in Developing Countries, 2015
Introduction: Different results have been achieved in the evaluation of antiparasitic drug activity in Mongolian jirds, hamsters, and BALB/c mice infected with Babesia microti.
Jun-ming Yao   +4 more
doaj   +1 more source

Synthesis of New N,N′‐Diarylureas and Their Theoretical Study as Cannabinoid‐1 Receptor Inhibitors

open access: yesChemPlusChem, EarlyView.
A series of new pyrazolo‐ and triazolo‐based N,N′‐diarylureas is synthesized following the triphosgene protocol in the last step. Density functional theory calculations and molecular docking provide strong evidence that all new compounds bind strongly to the cannabinoid‐1 (CB‐1) receptor, showing comparable results with the known allosteric CB‐1 ...
Eirini Tsemperlidou   +4 more
wiley   +1 more source

Paleoparasitology of Schistosomiasis [PDF]

open access: yesMemórias do Instituto Oswaldo Cruz, 1997
Eighteen years ago, when we began our studies in paleoparasitology, the main question proposed was whether Schistosoma mansoni infection has been really introduced by African slave trade in South America or has it been present among indians before Columbus. Up to now the question remains without answer, but it is interesting to point to some old
Luiz Fernando Ferreira, Adauto Araújo
openaire   +4 more sources

Profiling a Neo‐Antigen‐Driven Immune Response in Healthy Volunteers: A Randomized, Double‐Blind, Placebo‐Controlled Study of the KLH Challenge Model

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Novel compounds targeting the adaptive immune system are commonly initially investigated in healthy volunteers (HV). HV frequently lack constitutively expressed drug‐target engagement biomarkers, complicating the evaluation of pharmacological activity. The keyhole limpet hemocyanin (KLH) neo‐antigen challenge elicits a controlled immune response in HV ...
Micha N. Ronner   +10 more
wiley   +1 more source

Urban schistosomiasis: An ecological study describing a new challenge to the control of this neglected tropical disease

open access: yesThe Lancet Regional Health. Americas, 2022
Summary: Background: Social and environmental vulnerabilities contribute to the persistence and increase of Schistosomiasis, which has been a public health problem in Brazil and worldwide.
Elainne Christine de Souza Gomes   +5 more
doaj  

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

The Aetiology of Elevated Total Serum Immunoglobulin E in Children

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim The paucity of real‐world data on the aetiology of elevated total serum immunoglobulin E (TS‐IgE) in children afflicts families and health care systems with diagnostic uncertainty. We explored a cohort of children with TS‐IgE levels over 1000 kU/L, focusing on the prevalence of atopic and non‐atopic conditions, the aetiology of extremely ...
Aliisa Ärölä   +2 more
wiley   +1 more source

Estimation of changes in the force of infection for intestinal and urogenital schistosomiasis in countries with schistosomiasis control initiative-assisted programmes

open access: yesParasites & Vectors, 2015
Background The last decade has seen an expansion of national schistosomiasis control programmes in Africa based on large-scale preventative chemotherapy.
Michael D. French   +13 more
doaj   +1 more source

Comparative analysis of microRNA expression profiles of adult Schistosoma japonicum isolated from water buffalo and yellow cattle

open access: yesParasites & Vectors, 2019
Background Yellow cattle and water buffalo are important natural reservoir hosts and the main transmission sources of Schistosoma japonicum in endemic areas of China.
Xingang Yu   +9 more
doaj   +1 more source

Vouwo mud dye: A material, microbiological and cultural approach to researching sustainable textile dyes

open access: yesColoration Technology, EarlyView.
Abstract Coloration using soil‐based dyes is a fast‐growing subject of enquiry in fibres and textile surface design, with pigments and microbes involved in their production being extensively researched. Dyeing techniques using this rich natural resource have also been integral to long‐standing textile traditions worldwide.
Laurence Douny   +6 more
wiley   +1 more source

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