Results 21 to 30 of about 96,030 (249)

Small change, big difference: A promising praziquantel derivative designated P96 with broad-spectrum antischistosomal activity for chemotherapy of schistosomiasis japonica. [PDF]

PLoS Negl Trop Dis, 2023
Background Praziquantel (PZQ) has been the first line antischistosomal drug for all species of Schistosoma, and the only available drug for schistosomiasis japonica, without any alternative drugs since the 1980s.
Xu J, Dong LL, Sun H, Huang P, Zhang RZ, Wang XY, Sun DQ, Xia CM.   +7 more
europepmc   +2 more sources

Knocking Down Gm16685 Decreases Liver Granuloma in Murine Schistosomiasis Japonica. [PDF]

Microorganisms, 2023
Long noncoding RNAs (lncRNAs) can regulate key genes and pathways in liver disease development. Moreover, macrophages are speculated to play an important role in regulating granulomatous inflammation during schistosomiasis.
Zhao R, Tang X, Lin H, Xing C, Xu N, Dai B, Wang P, Shao W, Liu M, Shen J, Deng S, Ren C.   +11 more
europepmc   +2 more sources

Changing seroprevalence of schistosomiasis japonica in China from 1982 to 2020: A systematic review and spatial analysis. [PDF]

PLoS Negl Trop Dis
Background Schistosomiasis is a global public health issue. In China, while the seroprevalence of Schistosomiasis japonica has currently reduced to a relatively low level, risk of infection still exists in certain areas. However, there has been a lack of
Zhou Y, Zheng M, Gong Y, Huang J, Wang J, Xu N, Tong Y, Chen Y, Jiang Q, Cai Y, Zhou Y.   +10 more
europepmc   +2 more sources

High-throughput autoantibody profiling of different stages of Schistosomiasis japonica

Autoimmunity, 2023
Infection by the Schistosoma japonicum can result in acute, chronic and late-stage manifestations. The latter often presents with severe organ failures and premature death.
Xiaorong Zhou, Xi Wang, Jing Xu, Qi Tang, Robert Bergquist, Leming Shi, Zhiqiang Qin   +6 more
doaj   +2 more sources

Elimination of Schistosomiasis Japonica in China: From the One Health Perspective. [PDF]

China CDC Wkly, 2022
Schistosomiasis japonica is caused by infection of Schistosoma japonicum (S. japonicum), which infected 12 million residents in the 1950s in China and was a heavy burden to public health and socioeconomic development (1). After more than seven decades of
Hong Z, Li L, Zhang L, Wang Q, Xu J, Li S, Zhou XN.   +6 more
europepmc   +2 more sources

Diagnostic performance of a urine-based ELISA assay for the screening of human schistosomiasis japonica: A comparative study. [PDF]

Front Microbiol, 2022
The current study developed and evaluated the performance of a urine-based enzyme-linked immunosorbent assay (ELISA) for the screening of Schistosoma japonicum infection in a human cohort (n = 412) recruited from endemic areas, Northern Samar, the ...
Mu Y, Weerakoon KG, Olveda RM, Ross AG, McManus DP, Cai P.   +5 more
europepmc   +2 more sources

Dysregulated Glucuronidation of Bilirubin Exacerbates Liver Inflammation and Fibrosis in Schistosomiasis Japonica through the NF-κB Signaling Pathway. [PDF]

Pathogens
Hepatic fibrosis is an important pathological manifestation of chronic schistosome infection. Patients with advanced schistosomiasis show varying degrees of abnormalities in liver fibrosis indicators and bilirubin metabolism.
Xue Q, Wang Y, Liu Y, Hua H, Zhou X, Xu Y, Zhang Y, Xiong C, Liu X, Yang K, Huang Y.   +10 more
europepmc   +2 more sources

Cost-effectiveness analysis of the integrated control strategy for schistosomiasis japonica in a lake region of China: a case study. [PDF]

Infect Dis Poverty, 2021
Background Schistosomiasis japonica remains an important public health concern due to its potential to cause severe outcomes and long-term sequelae.
Wu LL, Hu HH, Zhang X, Zhou XN, Jia TW, Wang C, Hong Z, Xu J.   +7 more
europepmc   +2 more sources

Performance of the point-of-care circulating cathodic antigen test in the diagnosis of schistosomiasis japonica in a human cohort from Northern Samar, the Philippines. [PDF]

Infect Dis Poverty, 2021
Background Zoonotic schistosomiasis, caused by Schistosoma japonicum , remains a major public health problem in the Philippines. This study aimed to evaluate the commercially available rapid diagnostic point-of-care circulating cathodic antigen (POC-CCA)
Cai P, Mu Y, Weerakoon KG, Olveda RM, Ross AG, McManus DP.   +5 more
europepmc   +2 more sources

IL-33/ST2 Axis Deficiency Exacerbates Hepatic Pathology by Regulating Treg and Th17 Cells in Murine Schistosomiasis Japonica. [PDF]

J Inflamm Res, 2021
Purpose Schistosoma japonicum-infected IL-33 and ST2 gene deficiency (IL-33−/− and ST2−/−, respectively) mice were used to explore the role of the IL-33/ST2 axis in liver pathology targeting regulatory T cells (Treg)/T helper 17 cells (Th17).
Bai Y, Guan F, Zhu F, Jiang C, Xu X, Zheng F, Liu W, Lei J.   +7 more
europepmc   +2 more sources