Results 1 to 10 of about 640 (208)

Variation in response of Schistosoma mansoni strains to schistosomicides [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 1988
The BH strain of Schistosoma mansoni was found to be highly susceptible, to hy cant hone (1 x 80 mg/kg), oxamniquine (1 x 100 mg/kg) niridazole (5 x 100 mg/kg), praziquantel (1 x 100 mg/kg), oltipraz (5 x 125 mg/kg) and amoscanate (1 x 300 mg/kg) and is ...
BRUCE J. I., CAMPOS R., CIOLI D., COLES G. C., COLES G. C., COLES G. C., CRAWFORD K. A., DIAS L. C. S., DIAS L. C. S., DIAS L. C. S., Gerald C. Coles, JANSMA W. B., John I. Bruce, KATZ N., LIANG Y. S., LIANG Y. S., LOVERDE P. T., Luiz Cândido de Souza Dias, PELLEGRINO J., RADKE M. G., YARINSKY A.   +20 more
core   +8 more sources

Schistosomicidal activity of alkylaminooctanethiosulfuric acids [PDF]

Memórias do Instituto Oswaldo Cruz, 1994
The schistosomicidal activity of a new series of alkylaminooctanethiosulfuric acids was studied in white Swiss mice infected with the L.E. strain of Schistosoma mansoni (Belo Horizonte, MG, Brazil). In a preliminary screening of six compounds, two derivatives - 2-[(1-methylpropyl)amino]-1-octanethiosulfuric acid and 2-[(1-methylethyl)-amino]-1 ...
Penido, Marcus Luiz de Oliveira, Nelson, David Lee, Vieira, Leda Quércia, Coelho, Paulo Marcos Zech   +3 more
openaire   +6 more sources

The impact of MIF deficiency on alterations of fecal microbiota in C57BL/6 mice induced by Trichinella spiralis infection

The FASEB Journal, Volume 37, Issue 10, October 2023., 2023
Macrophage migration inhibitory factor (MIF) is closely related to the development of several parasitic diseases, including trichinellosis. To reveal the diversity and differences in fecal microbiota composition of Trichinella spiralis infected WT and MIF knockout C57BL/6 mice at different days post infection, the 16S rRNA amplicon sequencing was ...
Yiting Xie, Daoxiu Xu, Siyi Yan, Xinyi Hu, Sirui Chen, Kun Guo, Jue Wang, Qinghai Chen, Wei Guan   +8 more
wiley   +1 more source

The Role of Praziquantel in the Prevention and Treatment of Fibrosis Associated with Schistosomiasis: A Review

Journal of Tropical Medicine, Volume 2022, Issue 1, 2022., 2022
Schistosomiasis remains a major global public health concern. Currently, the control of this neglected tropical disease still depends on chemotherapy to reduce the prevalence and intensity of the parasite infection. It has been widely accepted that praziquantel is highly effective against all species of Schistosoma, and this agent is virtually the only
Xuehua Niu, Tao Hu, Ye Hong, Xiaoyan Li, Yuzhou Shen, Wei Wang   +5 more
wiley   +1 more source

Computer-Assisted Discovery of Alkaloids with Schistosomicidal Activity [PDF]

Current Issues in Molecular Biology, 2022
Schistosomiasis is a chronic parasitic disease caused by trematodes of the genus Schistosoma; it is commonly caused by Schistosoma mansoni, which is transmitted by Bioamphalaria snails. Studies show that more than 200 million people are infected and that more than 90% of them live in Africa.
Renata Priscila Barros de Menezes, Jéssika de Oliveira Viana, Eugene Muratov, Luciana Scotti, Marcus Tullius Scotti   +4 more
openaire   +3 more sources

Orally active antischistosomal early leads identified from the open access malaria box. [PDF]

, 2014
BACKGROUND: Worldwide hundreds of millions of schistosomiasis patients rely on treatment with a single drug, praziquantel. Therapeutic limitations and the threat of praziquantel resistance underline the need to discover and develop next generation drugs.
A Fenwick, AA Sayed, B Gryseels, B Ramirez, CE Cousin, CJ Murray, E Groll, Gordana Panic, J Keiser, J Keiser, J Keiser, J Keiser, J Keiser, J Keiser, J Utzinger, J Utzinger, JB Correa Soares, Jennifer Keiser, K Ingram, K Ingram, K Waisser, Katrin Ingram-Sieber, L Pica-Mattoccia, MH Abdulla, Mireille Vargas, Noemi Cowan, NR Mansour, Nuha R. Mansour, P Steinmann, Quentin D. Bickle, RA Paveley, S Denoyelle, S Knopp, SD Melman, SH Xiao, SH Xiao, SH Xiao, T Chen, T Manneck, T Spangenberg, Thomas Spangenberg, Timothy G. Geary, Timothy N. C. Wells   +42 more
core   +9 more sources

Resistance of Biomphalaria alexandrina to Schistosoma mansoni and Bulinus truncatus to Schistosoma haematobium Correlates with Unsaturated Fatty Acid Levels in the Snail Soft Tissue

Journal of Parasitology Research, Volume 2020, Issue 1, 2020., 2020
Only a fraction of the Biomphalaria and Bulinus snail community shows patent infection with schistosomes despite continuous exposure to the parasite, indicating that a substantial proportion of snails may resist infection. Accordingly, exterminating the schistosome intermediate snail hosts in transmission foci in habitats that may extend to kilometres ...
Marian Elias, Rasha S. Hanafi, Samia El-Bardicy, Ebtisam A. Hafez, Rashika El Ridi, Bernard Marchand   +5 more
wiley   +1 more source

Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs [PDF]

, 2009
Treatment with praziquantel (PZQ) has become virtually the sole basis of schistosomiasis control in sub-Saharan Africa and elsewhere, and the drug is reviewed here in the context of the increasing rate that it is being used for this purpose. Attention is
A. MBAYE, Alonso, Baard, Barakat, Botros, Botros, Cioli, D. CIOLI, D. ENGELS, G. COLES, Keiser, L. A. TCHUEM TCHUENTÉ, L. PICA-MATTOCCIA, M. J. DOENHOFF, Mwanakasale, N'Goran, P. HAGAN, Pica-Mattoccia, S. BOTROS, Stohler, Utzinger, V. SOUTHGATE, Van Wyk   +22 more
core   +2 more sources

Mirazid: A New Schistosomicidal Drug [PDF]

Pharmaceutical Biology, 2001
Schistosomiasis is a debilitating, and sometimes deadly, parasitic infection that afflicts hundreds of millions of people in developing countries. Great efforts have been devoted to develop a safe and an effective schistosomicidal agent. Myrrh is an oleo-gum-resin obtained from the stem of Commiphora molmol. An alcohol extract of this plant followed by
Osama Salama, Ahmed Masoud, F. Badria, G. Abou-Mohamed, A. El-Mowafy   +4 more
openaire   +2 more sources

Insucesso na indução de resistência a drogas esquistossomicidas em uma cepa brasileira humana de Schistosoma mansoni [PDF]

, 1986
In this work, an attempt was made to induceng resistance to 3 schistosomicidal drugs in a Brazilian strain of S. mansoni, according to the Type II resistance induction scheme proposed by JANSMA et al. in 1977. Three attempts were unsuccessful.
Dias, Luiz Candido de Souza, Olivier, Celso Eduardo   +1 more
core   +4 more sources