Results 151 to 160 of about 640 (208)

New Aminoquinoline with Schistosomicidal Activity [PDF]

Nature, 1967
DURING routine testing of compounds, we have discovered schistosomicidal activity in a series of 5-aminoquinolines. Many compounds with this general formula were made and tested and some were found to have activity, but one compound was outstanding. This was 6-chloro-5-β-diethylaminoethylamino-8-methylquinoline.
B. Lessel, N. W. Bristow, G. A. H. Williams, H. C. Richards, H. C. Richards   +4 more
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The toxicology of the schistosomicidal agent oxamniquine

Drug Development Research, 1984
AbstractOxamniquine displayed low acute toxicity in mice, hamsters, and rabbits. In rats, however, oxamniquine was much more toxic, the female being 8–10 times more sensitive than the male; single doses elicited an idiosyncratic sex‐linked hepatic necrosis and bile duct proliferation.
R. M. Quinton, R. M. Hull, J. Perraud, H. H. Reinert, M. H. Gregory, M. Chvédoff, A.M. Monro, J. M. Faccini   +7 more
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Schistosomicidal Activity of Dihydrobenzofuran Neolignans

Chemistry & Biodiversity, 2018
We have evaluated the antischistosomal activity of synthetic dihydrobenzofuran neolignans (DBNs) derived from (±)‐trans‐dehydrodicoumaric acid dimethyl ester (1) and (±)‐trans‐dehydrodiferulic acid dimethyl ester (2) against adult Schistosoma mansoni worms in vitro.
Herbert J. Dias, Vanderlei Rodrigues, Murilo J. Fukui, Mariana Cintra Pagotti, Antônio Eduardo Miller Crotti, Lizandra Guidi Magalhães, Andressa Barban do Patrocinio   +6 more
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ChemInform Abstract: SYNTHESIS OF A NEW SCHISTOSOMICIDE

Chemischer Informationsdienst, 1980
AbstractDas Thiazol (II) wird in Gegenwart von Natriumhydrid oder Natriumethylat mit dem Azauracil (I) zum 6‐Thiazolylamino‐l ,2,4‐ triazindion (III) kondensiert.
I. Nabih, M. Saddik, M. M. Kamel
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Fungal Transformation and Schistosomicidal Effects of Pimaradienoic Acid

Chemistry & Biodiversity, 2012
AbstractThe schistosomicidal effects of pimaradienoic acid (PA) and two derivatives, obtained by fungal transformation in the presence of Aspergillus ochraceus, were investigated. PA was the only compound with antischistosomal activity among the three diterpenes studied, with the ability to significantly reduce the viability of the parasites at ...
Thiago S. Porto, Nilton S. Arakawa, Vanderlei Rodrigues, Ademar A. da Silva Filho, Lizandra Guidi Magalhães, Raquel Alves dos Santos, Dionéia Camilo Rodrigues de Oliveira, Niege Araçari Jacometti Cardoso Furtado, Suraia Said, Luiz E. Gregório, Sérgio Ricardo Ambrósio, Rodrigo Cassio Sola Veneziani   +11 more
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Cytochalasin D abolishes the schistosomicidal activity of praziquantel

Experimental Parasitology, 2007
To test the hypothesis that calcium channels of schistosomes are the targets for the action of praziquantel, we subjected schistosomes in vitro to pharmacological agents capable of interfering with the functioning of calcium channels. After 1-h exposure to these agents, praziquantel was added and incubation continued overnight.
PicaMattoccia L, Valle C, Basso A, Troiani AR, Vigorosi F, Liberti P, Festucci A, Cioli D   +7 more
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Furofuran lignans display schistosomicidal and trypanocidal activities

Phytochemistry, 2014
Parasitic diseases continue to be a major worldwide health problem, and there is an urgent need for development of therapeutic drugs. This paper describes synthesis of dehydrodiferulic acid dilactone 1 and dehydrodisinapic acid dilactone 2 furofuran lignans by oxidative coupling of ferulic and sinapic acids, respectively.
Ana Carolina, Pereira, Viviane Rodrigues, Esperandim, Daniele, Ferreira da Silva, Daniele da Silva, Ferreira, Lizandra Guidi, Magalhães, Thais Coelho, Lima, Dhammika N P, Nanayakkara, Wilson Roberto, Cunha, Jairo Kenupp, Bastos, Márcio Luis, Andrade e Silva   +9 more
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Structure and Activity of Schistosomicidal Agents of the Pyrimidine Type

Journal of Pharmaceutical Sciences, 1972
Abstract To profit from the concept of metabolite antagonism in the area of schistosomiasis chemotherapy, new compounds containing combinations of both substituted pyrimidine (closely related to the pyrimidine moiety present in thiamine) and 5-nitrothiazole or 2-imidazolidinethione moieties were synthesized.
I. Nabih, H. Zoorob
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Laboratory evaluation of schistosomicidal substances

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1967
Abstract The broad approaches to experimental chemotherapy of schistosomiasis are reviewed and the biological principles on which assessment of drug action can be made are discussed. The type of activity required in schistosomicides can be prophylactic, egg-suppressive or curative, and the method of assessment will vary accordingly.
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Structure and Activity of Thiazole-Type Schistosomicidal Agents [PDF]

Journal of Pharmaceutical Sciences, 1972
The schistosomicidal agent 1-(5′-nitro-2′-thiazolyl)-2-imidazolidinone caused a rise in the α-keto acid level when given orally to rats. This effect could be diminished upon parallel administration of high doses of the vitamin thiamine. The biological effect of the drug could also be canceled through similar administration of the vitamin.
F. El-Hawary, H. Zoorob, I. Nabih
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