Results 11 to 20 of about 879 (214)

Exposure to Hycanthone alters chromatin structure around specific gene functions and specific repeats in Schistosoma mansoni [PDF]

Frontiers in Genetics, 2014
Schistosoma mansoni is a parasitic plathyhelminth responsible for intestinal schistosomiasis (or bilharziasis), a disease affecting 67 million people worldwide and causing an important economic burden. The schistosomicides hycanthone, and its later proxy
David eRoquis, David eRoquis, Julie MJ Lepesant, Julie MJ Lepesant, Emanuel eVillafan, Emanuel eVillafan, Cristina eVieira, Céline eCosseau, Céline eCosseau, Christoph eGrunau, Christoph eGrunau   +10 more
doaj   +4 more sources

Guidelines for the diagnosis and treatment of schistosomal myeloradiculopathy Orientações sobre o diagnóstico e tratamento da mielorradiculopatia associada à esquistossomose [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 2007
Schistosomal myeloradiculopathy is the most severe and disabling ectopic form of Schistosoma mansoni infection. The prevalence of SMR in centres in Brazil and Africa that specialise in attending patients with non traumatic myelopathy is around 5%.
José Roberto Lambertucci, Luciana Cristina dos Santos Silva, Ronaldo Santos do Amaral   +2 more
doaj   +2 more sources

The Role of Praziquantel in the Prevention and Treatment of Fibrosis Associated with Schistosomiasis: A Review

Journal of Tropical Medicine, Volume 2022, Issue 1, 2022., 2022
Schistosomiasis remains a major global public health concern. Currently, the control of this neglected tropical disease still depends on chemotherapy to reduce the prevalence and intensity of the parasite infection. It has been widely accepted that praziquantel is highly effective against all species of Schistosoma, and this agent is virtually the only
Xuehua Niu, Tao Hu, Ye Hong, Xiaoyan Li, Yuzhou Shen, Wei Wang   +5 more
wiley   +1 more source

Computer-Assisted Discovery of Alkaloids with Schistosomicidal Activity [PDF]

Current Issues in Molecular Biology, 2022
Schistosomiasis is a chronic parasitic disease caused by trematodes of the genus Schistosoma; it is commonly caused by Schistosoma mansoni, which is transmitted by Bioamphalaria snails. Studies show that more than 200 million people are infected and that more than 90% of them live in Africa.
Renata Priscila Barros de Menezes, Jéssika de Oliveira Viana, Eugene Muratov, Luciana Scotti, Marcus Tullius Scotti   +4 more
openaire   +3 more sources

Orally active antischistosomal early leads identified from the open access malaria box. [PDF]

, 2014
BACKGROUND: Worldwide hundreds of millions of schistosomiasis patients rely on treatment with a single drug, praziquantel. Therapeutic limitations and the threat of praziquantel resistance underline the need to discover and develop next generation drugs.
A Fenwick, AA Sayed, B Gryseels, B Ramirez, CE Cousin, CJ Murray, E Groll, Gordana Panic, J Keiser, J Keiser, J Keiser, J Keiser, J Keiser, J Keiser, J Utzinger, J Utzinger, JB Correa Soares, Jennifer Keiser, K Ingram, K Ingram, K Waisser, Katrin Ingram-Sieber, L Pica-Mattoccia, MH Abdulla, Mireille Vargas, Noemi Cowan, NR Mansour, Nuha R. Mansour, P Steinmann, Quentin D. Bickle, RA Paveley, S Denoyelle, S Knopp, SD Melman, SH Xiao, SH Xiao, SH Xiao, T Chen, T Manneck, T Spangenberg, Thomas Spangenberg, Timothy G. Geary, Timothy N. C. Wells   +42 more
core   +9 more sources

Resistance of Biomphalaria alexandrina to Schistosoma mansoni and Bulinus truncatus to Schistosoma haematobium Correlates with Unsaturated Fatty Acid Levels in the Snail Soft Tissue

Journal of Parasitology Research, Volume 2020, Issue 1, 2020., 2020
Only a fraction of the Biomphalaria and Bulinus snail community shows patent infection with schistosomes despite continuous exposure to the parasite, indicating that a substantial proportion of snails may resist infection. Accordingly, exterminating the schistosome intermediate snail hosts in transmission foci in habitats that may extend to kilometres ...
Marian Elias, Rasha S. Hanafi, Samia El-Bardicy, Ebtisam A. Hafez, Rashika El Ridi, Bernard Marchand   +5 more
wiley   +1 more source

An analysis of the impact of the Schistosomiasis Control Programme in Brazil [PDF]

, 2006
The impact of the Schistosomiasis Control Programme (PCE) in Brazil was analyzed, covering the period 1976 to 2003, using the following indicators: percentage of Schistosoma mansoni carriers detected among the population examined in the coproscopic ...
Amaral, Ronaldo Santos do, Engels, Dirk, Lima, David Duarte, Tauil, Pedro Luiz   +3 more
core   +5 more sources

Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs [PDF]

, 2009
Treatment with praziquantel (PZQ) has become virtually the sole basis of schistosomiasis control in sub-Saharan Africa and elsewhere, and the drug is reviewed here in the context of the increasing rate that it is being used for this purpose. Attention is
A. MBAYE, Alonso, Baard, Barakat, Botros, Botros, Cioli, D. CIOLI, D. ENGELS, G. COLES, Keiser, L. A. TCHUEM TCHUENTÉ, L. PICA-MATTOCCIA, M. J. DOENHOFF, Mwanakasale, N'Goran, P. HAGAN, Pica-Mattoccia, S. BOTROS, Stohler, Utzinger, V. SOUTHGATE, Van Wyk   +22 more
core   +2 more sources

Mirazid: A New Schistosomicidal Drug [PDF]

Pharmaceutical Biology, 2001
Schistosomiasis is a debilitating, and sometimes deadly, parasitic infection that afflicts hundreds of millions of people in developing countries. Great efforts have been devoted to develop a safe and an effective schistosomicidal agent. Myrrh is an oleo-gum-resin obtained from the stem of Commiphora molmol. An alcohol extract of this plant followed by
Osama Salama, Ahmed Masoud, F. Badria, G. Abou-Mohamed, A. El-Mowafy   +4 more
openaire   +2 more sources

Strain variation in the infectivity of Schistosoma mansoni for Biomphalaria glabrata

Revista do Instituto de Medicina Tropical de São Paulo, 1988
Five strains of Schistosoma mansoni resistant and susceptible to schistosomicides were studied for infectivity of 2 strains of Biomphalaria glabrata one of Puerto Rican origin and the other of Brazilian origin. Puerto Rican strains of S.
Luiz Candido de Souza Dias, John I. Bruce, Gerald C. Coles   +2 more
doaj   +1 more source