Results 121 to 130 of about 252,158 (241)

Risk of injury associated with the sedative potential of second‐generation antihistamines: A nationwide retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Individual second‐generation antihistamines may possess differential sedative potential due to the variability in central histamine receptor H1 occupancy. This study aimed to evaluate whether the sedative potential of second‐generation antihistamines is associated with the risk of injury during Japan's pollen season. Methods We conducted a
Jumpei Taniguchi, Shotaro Aso, So Sato, Hideo Yasunaga   +3 more
wiley   +1 more source

Pharmacogenomics of Major Depressive Disorder in Indigenous Amazonian Populations

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder is a highly prevalent psychological disorder worldwide and its main treatment is the use of Selective Serotonin Reuptake Inhibitors. However, few studies have demonstrated the relationship between the presence of genetic variants in pharmacogenes and the efficacy of these drugs, especially in populations with a unique genetic ...
Kaio Evandro Cardoso Aguiar, Natasha Monte da Silva, Juliana Carla Gomes Rodrigues, André Maurício Ribeiro‐dos‐Santos, Sandro José de Souza, Ândrea Ribeiro‐dos‐Santos, João Farias Guerreiro, Sidney Emanuel Batista dos Santos, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +9 more
wiley   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Pharmacokinetic Drug–Drug Interaction Potential of Oral Anticancer Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Drug–drug interaction (DDI) management is critical for safe and effective use of oral anticancer drugs (OADs). Our study objectives were to (i) compile clinically relevant pharmacokinetic (PK) DDI mechanisms for OADs and (ii) assess the prevalence of PK potential DDIs (PDDIs) in patients with advanced solid cancers.
Fatimah Alhurayri, Islam R. Younis, Shadia I. Jalal, Theodore F. Logan, Rohan Maniar, Steven M. Bray, Sara K. Quinney, Zeruesenay Desta, Todd C. Skaar, James E. Tisdale, Tyler Shugg   +10 more
wiley   +1 more source

Patient‐ and Clinician‐Related Factors Associated With the Reduction in Opioid Use Among Adults With Chronic Non‐Cancer Pain: A Systematic Review

Clinical Pharmacology &Therapeutics, EarlyView.
Despite known risks, opioids are widely used for chronic non‐cancer pain (CNCP). Clinical guidelines now recommend deprescribing, but factors predicting success are poorly understood. This systematic review aimed to identify clinician and patient factors associated with attaining successful opioid dose reduction or discontinuation in adults with CNCP ...
Alessandra C. Marcelo, Sarah N. Hilmer, David J. Hunter, Stephanie Mathieson, Riyaas Mohamed, Leo Li, Natalie Fung, Anthony Yue, Manuela L. Ferreira   +8 more
wiley   +1 more source

Neurofeedback for Binge‐Eating Disorder: Neurophysiological Outcome Predictors and Rapid Response

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Pioneer studies suggested the effectiveness of food‐specific electroencephalography (EEG) and real‐time functional near‐infrared spectroscopy (rtfNIRS) neurofeedback (NF) trainings in the treatment of binge‐eating disorder (BED). These trainings aim to improve participants' neurophysiological self‐regulation.
Ben Schreglmann, Ricarda Schmidt, Michael Lührs, Anja Hilbert   +3 more
wiley   +1 more source

A Program‐Led Motivational App (MI‐Coach: ED) for Eating Disorder Waitlists: Findings From a Feasibility and Acceptability Pilot Trial

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Individuals with eating disorders (EDs) often face significant barriers to accessing care, including prolonged waitlists and systemic delays. Digital interventions, such as mobile apps, offer a scalable way to enhance pre‐treatment engagement during this high‐risk period.
Amané Halicki‐Asakawa, Emily Fuller, Maya Libben   +2 more
wiley   +1 more source

Le groupe d’insertion sociale et professionnelle : apprentissages et développement au cœur de l’activité collective de personnes en situation de chômage de longue durée [PDF]

, 2015
Cette recherche porte sur l’activité au cours des groupes comme source d’apprentissage et de développement des personnes en chômage de longue durée en vue de leur insertion sociale et professionnelle (ISP).
Dionne, Patricia
core   +1 more source

A Commentary on “Comparing Operationalizations of Eating Disorder Recovery Using a Comprehensive Lens: Physical, Behavioral, and Cognitive Domains” by Bardone‐Cone et al.

International Journal of Eating Disorders, EarlyView.
ABSTRACT Defining recovery in eating disorders remains a major challenge due to the absence of standardized, empirically validated criteria. Bardone‐Cone et al. (2025) address this gap by testing multidimensional, transdiagnostic recovery criteria spanning physical, behavioral, and cognitive domains.
Charlotte Bovenberg, Suman Ambwani, Valentina Cardi, Janet Treasure   +3 more
wiley   +1 more source

Executive functions and self‐limited epilepsy with centro‐temporal spikes: A scoping review

Epileptic Disorders, EarlyView.
Abstract Executive functions are a set of high‐level cognitive processes necessary for planning, organization, decision‐making, self‐control, and attention, and are carried out in the anterior frontal lobes. An impairment in executive functioning might present as difficulties in planning and organizing activities, in attention and concentration, in ...
Edoardo Fino, Martina Calì, Sara Senese, Simona Pellacani, Viola Margheri, Chiara Pecini, Carmen Barba   +6 more
wiley   +1 more source