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Transcriptional evidence of reduced BDNF trophic capacity in the post-mortem human midbrain of schizophrenia cases with high inflammation [PDF]
Translational PsychiatryElevated inflammation in the midbrain of ~45% of people with schizophrenia may relate to altered trophic support for neurons. Dopamine neurons require trophic support from Brain-Derived Neurotrophic Factor (BDNF), that signals via the full-length ...
Jessica J. Chandra +6 more
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The Lancet, 2022 Schizophrenia, characterised by psychotic symptoms and in many cases social and occupational decline, remains an aetiological and therapeutic challenge. Contrary to popular belief, the disorder is modestly more common in men than in women. Nor is the outcome uniformly poor.
Jauhar, Sameer +2 more
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The Lancet, 2016 Schizophrenia is a complex, heterogeneous behavioural and cognitive syndrome that seems to originate from disruption of brain development caused by genetic or environmental factors, or both. Dysfunction of dopaminergic neurotransmission contributes to the genesis of psychotic symptoms, but evidence also points to a widespread and variable involvement ...
Michael J Owen +2 more
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Medicine, 2012 Schizophrenia is a severe mental illness affecting several domains of cognition and behaviour. The illness most frequently becomes manifest in early adulthood, and often follows a chronic course. It is associated with high morbidity and mortality, and is a leading contributor to disease burden, health and social care costs throughout the world ...
Meyer, Nicholas, MacCabe, James H.
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Deutsches Ärzteblatt international, 2020 The lifetime prevalence of schizophrenia is 1%. Schizophrenia is among the most severe mental illnesses and gives rise to the highest treatment costs per patient of any disease. It is characterized by frequent relapses, marked impairment of quality of life, and reduced social and work participation.The group entrusted with the creation of the German ...
Hasan, Alkomiet +3 more
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Learnings from conducting mental health research during 2004 tsunami in Tamil Nadu, India
BMC Public Health, 2020 Background The Indian Ocean tsunami experience in 2004 caused a major loss of life and subsequent emotional trauma for survivors. Psychosocial needs in the aftermath of this disaster were extensive, yet the cohesion and effectiveness of response were ...
R. Padmavati +6 more
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Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia
Molecular Brain, 2021 Reductions in the GABAergic neurotransmitter system exist across multiple brain regions in schizophrenia and encompass both pre- and postsynaptic components.
Tertia D. Purves-Tyson +4 more
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Pharmacology Research & Perspectives, 2023 The antioxidant L‐Carnosine is reported to improve negative and cognitive symptoms in Schizophrenia. A randomized double‐blind placebo‐controlled study was planned to study the effectiveness of adjuvant L‐Carnosine therapy in patients with Schizophrenia.
Hema Tharoor +5 more
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Frequency of clinical appointments in subjects with emergent suicidal ideation
European Psychiatry, 2022 Introduction Schizophrenia is a psychotic disorder strongly associated with suicidal behaviour up to 20-50 times higher than those in the general population.
J. Qian, N. Yasmin, V. Deluca
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Psychoeducation for schizophrenia [PDF]
Cochrane Database of Systematic Reviews, 2010 Schizophrenia can be a severe and chronic illness characterised by lack of insight and poor compliance with treatment. Psychoeducational approaches have been developed to increase patients' knowledge of, and insight into, their illness and its treatment.
Xia, Jun +2 more
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