Results 1 to 10 of about 518,667 (168)
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Nature, 2022 Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant V. Trubetskoy, A. Pardiñas, Ting Qi, G. Panagiotaropoulou, S. Awasthi, T. Bigdeli, J. Bryois, Chia-Yen Chen, C. Dennison, L. Hall, Max W. Y. Lam, Kyoko Watanabe, O. Frei, T. Ge, J. Harwood, F. Koopmans, S. Magnússon, A. Richards, J. Sidorenko, Yang Wu, Jian Zeng, J. Grove, Minsoo Kim, Zhiqiang Li, G. Voloudakis, Wen Zhang, M. Adams, I. Agartz, Elizabeth G. Atkinson, E. Agerbo, M. A. Al Eissa, M. Albus, Madeline Alexander, B. Alizadeh, K. Alptekin, T. Als, F. Amin, V. Arolt, M. Arrojo, L. Athanasiu, M. Azevedo, S. Bacanu, N. Bass, M. Begemann, R. Belliveau, J. Bene, Beben Benyamin, Sarah E. Bergen, G. Blasi, J. Bobes, S. Bonassi, A. Braun, R. Bressan, E. Bromet, R. Bruggeman, P. Buckley, R. Buckner, J. Bybjerg-Grauholm, W. Cahn, M. Cairns, M. Calkins, V. Carr, D. Castle, S. Catts, Kimberley D. Chambert, R. Chan, B. Chaumette, Wei Cheng, E. Cheung, S. Chong, D. Cohen, A. Consoli, Q. Cordeiro, J. Costas, C. Curtis, Michal Davidson, K. Davis, L. de Haan, F. Degenhardt, L. DeLisi, D. Demontis, F. Dickerson, D. Dikeos, T. Dinan, S. Djurovic, J. Duan, G. Ducci, F. Dudbridge, J. Eriksson, L. Fañanás, S. Faraone, A. Fiorentino, A. Forstner, J. Frank, N. Freimer, M. Fromer, A. Frustaci, A. Gadelha, G. Genovese, E. Gershon, M. Giannitelli, I. Giegling, P. Giusti-Rodríguez, S. Godard, J. Goldstein, Javier González Peñas, A. González-Pinto, S. Gopal, J. Gratten, Michael F. Green, T. Greenwood, O. Guillin, S. Gülöksüz, R. Gur, R. Gur, B. Gutiérrez, E. Hahn, H. Hakonarson, V. Haroutunian, A. Hartmann, C. Harvey, C. Hayward, F. Henskens, S. Herms, P. Hoffmann, D. Howrigan, M. Ikeda, C. Iyegbe, I. Joa, A. Julià, A. Kähler, Tony Kam-Thong, Y. Kamatani, Sena Karachanak-Yankova, O. Kebir, M. Keller, B. Kelly, A. Khrunin, Sung-Wan Kim, J. Kloviņš, N. Kondratiev, B. Konte, J. Kraft, M. Kubo, V. Kučinskas, Z. Kučinskienė, A. Kusumawardhani, Hana Kuzelova-Ptackova, S. Landi, L. Lazzeroni, Phil H. Lee, S. Legge, D. Lehrer, R. Lencer, B. Lerer, Miaoxin Li, J. Lieberman, G. Light, S. Limborska, Chih-Min Liu, J. Lönnqvist, C. Loughland, J. Lubiński, J. Luykx, A. Lynham, M. Macek, Andrew Mackinnon, P. Magnusson, B. Maher, W. Maier, D. Malaspina, J. Mallet, S. Marder, S. Marsal, Alicia R. Martin, L. Martorell, M. Mattheisen, R. McCarley, C. Mcdonald, J. McGrath, H. Medeiros, S. Meier, B. Melegh, I. Melle, R. Mesholam-Gately, A. Metspalu, P. Michie, L. Milani, V. Milanova, M. Mitjans, E. Molden, E. Molina, M. Moltó, V. Mondelli, C. Moreno, C. Morley, G. Muntané, K. Murphy, I. Myin‐Germeys, I. Nenadić, G. Nestadt, L. Nikitina-Zake, Cristiano Noto, K. Nuechterlein, N. O’Brien, F. O'Neill, Sang-Yun Oh, A. Olincy, V. Ota, C. Pantelis, G. Papadimitriou, M. Parellada, T. Paunio, R. Pellegrino, S. Periyasamy, D. Perkins, B. Pfuhlmann, O. Pietiläinen, J. Pimm, D. Porteous, J. Powell, D. Quattrone, D. Quested, A. Radant, A. Rampino, M. Rapaport, A. Rautanen, A. Reichenberg, Cheryl A. Roe, J. Roffman, Julian Roth, M. Rothermundt, B. Rutten, Safa Saker-Delye, V. Salomaa, J. Sanjuán, M. Santoro, A. Savitz, U. Schall, Rodney J. Scott, L. Seidman, S. Sharp, Jianxin Shi, L. Siever, E. Sigurdsson, K. Sim, Nora Skarabis, P. Slominsky, H. So, J. Sobell, E. Söderman, H. Stain, N. E. Steen, Agnes A. Steixner-Kumar, Elisabeth Stögmann, W. Stone, R. Straub, F. Streit, E. Strengman, T. Stroup, M. Subramaniam, Catherine A. Sugar, J. Suvisaari, D. Svrakic, N. Swerdlow, J. Szatkiewicz, T. Ta, A. Takahashi, C. Terao, F. Thibaut, D. Toncheva, P. Tooney, Silvia Torretta, S. Tosato, G. Tura, B. Turetsky, A. Üçok, A. Vaaler, T. van Amelsvoort, R. van Winkel, J. Veijola, J. Waddington, H. Walter, A. Waterreus, B. Webb, M. Weiser, N. Williams, S. Witt, B. Wormley, J. Wu, Zhida Xu, R. Yolken, C. Zai, Wei Zhou, Feng Zhu, F. Zimprich, E. Atbasoglu, M. Ayub, C. Benner, A. Bertolino, D. Black, N. Bray, G. Breen, N. Buccola, W. Byerley, Wei J. Chen, C. Cloninger, B. Crespo-Facorro, G. Donohoe, R. Freedman, C. Galletly, Michael Jeffrey Gandal, M. Gennarelli, D. Hougaard, H. Hwu, A. Jablensky, S. Mccarroll, J. Moran, O. Mors, P. Mortensen, B. Müller-Myhsok, A. Neil, M. Nordentoft, M. Pato, T. Petryshen, M. Pirinen, A. Pulver, T. Schulze, J. Silverman, J. Smoller, E. Stahl, D. Tsuang, E. Vilella, Shi-Heng Wang, Shuhua Xu, R. Adolfsson, C. Arango, B. Baune, S. Belangero, A. Børglum, D. Braff, E. Bramon, J. Buxbaum, D. Campion, J. Cervilla, S. Cichon, David A. Collier, A. Corvin, D. Curtis, M. Forti, E. Domenici, H. Ehrenreich, V. Escott-Price, T. Esko, A. Fanous, A. Gareeva, M. Gawlik, P. Gejman, M. Gill, S. Glatt, V. Golimbet, K. Hong, C. Hultman, S. Hyman, N. Iwata, E. Jönsson, R. Kahn, James L. Kennedy, E. Khusnutdinova, G. Kirov, J. Knowles, M. Krebs, C. Laurent-Levinson, Jimmy Lee, T. Lencz, D. Levinson, Qingqin S. Li, J. Liu, A. Malhotra, D. Malhotra, A. McIntosh, A. McQuillin, P. Menezes, V. Morgan, D. Morris, B. Mowry, Robin M. Murray, V. Nimgaonkar, M. Nöthen, R. Ophoff, S. Paciga, A. Palotie, C. Pato, Shengying Qin, M. Rietschel, B. Riley, M. Rivera, D. Rujescu, M. Saka, A. Sanders, S. Schwab, A. Serretti, P. Sham, Yongyong Shi, D. St. Clair, H. Stefánsson, K. Stefánsson, M. Tsuang, J. van os, M. Vawter, D. Weinberger, T. Werge, D. Wildenauer, Xin Yu, W. Yue, P. Holmans, A. Pocklington, P. Roussos, E. Vassos, M. Verhage, P. Visscher, Jian Yang, D. Posthuma, O. Andreassen, K. Kendler, M. Owen, N. Wray, M. Daly, Hailiang Huang, B. Neale, Patrick F. Sullivan, S. Ripke, J. Walters, M. O’Donovan +433 moresemanticscholar +1 more sourceIncidence, prevalence, and global burden of schizophrenia - data, with critical appraisal, from the Global Burden of Disease (GBD) 2019
Molecular Psychiatry, 2023 Schizophrenia substantially contributes to the burden of mental disorders. Schizophrenia’s burden and epidemiological estimates in some countries have been published, but updated estimates of prevalence, incidence, and schizophrenia-related disability at Marco Solmi, G. Seitidis, D. Mavridis, C. Correll, E. Dragioti, Synthia Guimond, L. Tuominen, Aroldo Dargél, A. Carvalho, M. Fornaro, Michael Maes, Francesco Monaco, Minjin Song, J. Il Shin, S. Cortese +14 moresemanticscholar +1 more sourceRare coding variants in 10 genes confer substantial risk for schizophrenia
Nature, 2022 Rare coding variation has historically provided the most direct connections between gene function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 schizophrenia cases and 97,322 controls, we implicate ultra-rare coding variants ...T. Singh, T. Poterba, D. Curtis, H. Akil, M. A. Al Eissa, J. Barchas, N. Bass, T. Bigdeli, G. Breen, E. Bromet, P. F. Buckley, W. Bunney, J. Bybjerg-Grauholm, W. Byerley, S. Chapman, Wei J. Chen, C. Churchhouse, N. Craddock, C. Cusick, L. DeLisi, S. Dodge, M. Escamilla, S. Eskelinen, A. Fanous, S. Faraone, A. Fiorentino, L. Francioli, S. Gabriel, D. Gage, S. G. Gagliano Taliun, A. Ganna, G. Genovese, D. Glahn, J. Grove, M. Hall, E. Hämäläinen, H. Heyne, M. Holi, D. Hougaard, D. Howrigan, Hailiang Huang, H. Hwu, R. Kahn, H. Kang, K. Karczewski, G. Kirov, J. Knowles, F. Lee, D. Lehrer, F. Lescai, D. Malaspina, S. Marder, S. Mccarroll, A. McIntosh, H. Medeiros, L. Milani, C. Morley, D. Morris, P. Mortensen, R. Myers, M. Nordentoft, N. O’Brien, A. M. Olivares, D. Ongur, W. Ouwehand, D. Palmer, T. Paunio, D. Quested, M. Rapaport, E. Rees, B. Rollins, F. Satterstrom, A. Schatzberg, E. Scolnick, L. Scott, Sally Sharp, P. Sklar, J. Smoller, J. Sobell, M. Solomonson, E. Stahl, C. Stevens, J. Suvisaari, G. Tiao, S. Watson, N. Watts, D. Blackwood, A. Børglum, B. Cohen, A. Corvin, T. Esko, N. Freimer, S. Glatt, C. Hultman, A. McQuillin, A. Palotie, C. Pato, M. Pato, A. Pulver, D. St. Clair, M. Tsuang, M. Vawter, J. Walters, T. Werge, R. Ophoff, Patrick F. Sullivan, M. Owen, M. Boehnke, M. O’Donovan, B. Neale, M. Daly +110 moresemanticscholar +1 more sourceMortality in people with schizophrenia: a systematic review and meta‐analysis of relative risk and aggravating or attenuating factors
World Psychiatry, 2022 People with schizophrenia die 15‐20 years prematurely. Understanding mortality risk and aggravating/attenuating factors is essential to reduce this gap.C. Correll, Marco Solmi, Giovanni Croatto, Lynne Kolton Schneider, S. Rohani-Montez, Leanne Fairley, Nathalie Smith, I. Bitter, P. Gorwood, H. Taipale, J. Tiihonen +10 moresemanticscholar +1 more source
