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The Lancet, 2016 Schizophrenia is a complex, heterogeneous behavioural and cognitive syndrome that seems to originate from disruption of brain development caused by genetic or environmental factors, or both. Dysfunction of dopaminergic neurotransmission contributes to the genesis of psychotic symptoms, but evidence also points to a widespread and variable involvement ...
Michael J Owen +2 more
semanticscholar +9 more sources
Transcriptional evidence of reduced BDNF trophic capacity in the post-mortem human midbrain of schizophrenia cases with high inflammation [PDF]
Translational PsychiatryElevated inflammation in the midbrain of ~45% of people with schizophrenia may relate to altered trophic support for neurons. Dopamine neurons require trophic support from Brain-Derived Neurotrophic Factor (BDNF), that signals via the full-length ...
Jessica J. Chandra +6 more
doaj +2 more sources
The Lancet, 2022 Schizophrenia, characterised by psychotic symptoms and in many cases social and occupational decline, remains an aetiological and therapeutic challenge. Contrary to popular belief, the disorder is modestly more common in men than in women. Nor is the outcome uniformly poor.
Jauhar, Sameer +2 more
openaire +3 more sources
Motor deficits in schizophrenia quantified by nonlinear analysis of postural sway. [PDF]
, 2012 Motor dysfunction is a consistently reported but understudied aspect of schizophrenia. Postural sway area was examined in individuals with schizophrenia under four conditions with different amounts of visual and proprioceptive feedback: eyes open or ...
Bolbecker, Amanda R. +6 more
core +16 more sources
Medicine, 2012 Schizophrenia is a severe mental illness affecting several domains of cognition and behaviour. The illness most frequently becomes manifest in early adulthood, and often follows a chronic course. It is associated with high morbidity and mortality, and is a leading contributor to disease burden, health and social care costs throughout the world ...
Meyer, Nicholas, MacCabe, James H.
openaire +7 more sources
Deutsches Ärzteblatt international, 2020 The lifetime prevalence of schizophrenia is 1%. Schizophrenia is among the most severe mental illnesses and gives rise to the highest treatment costs per patient of any disease. It is characterized by frequent relapses, marked impairment of quality of life, and reduced social and work participation.The group entrusted with the creation of the German ...
Hasan, Alkomiet +3 more
openaire +6 more sources
Learnings from conducting mental health research during 2004 tsunami in Tamil Nadu, India
BMC Public Health, 2020 Background The Indian Ocean tsunami experience in 2004 caused a major loss of life and subsequent emotional trauma for survivors. Psychosocial needs in the aftermath of this disaster were extensive, yet the cohesion and effectiveness of response were ...
R. Padmavati +6 more
doaj +1 more source
Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia
Molecular Brain, 2021 Reductions in the GABAergic neurotransmitter system exist across multiple brain regions in schizophrenia and encompass both pre- and postsynaptic components.
Tertia D. Purves-Tyson +4 more
doaj +1 more source
Pharmacology Research & Perspectives, 2023 The antioxidant L‐Carnosine is reported to improve negative and cognitive symptoms in Schizophrenia. A randomized double‐blind placebo‐controlled study was planned to study the effectiveness of adjuvant L‐Carnosine therapy in patients with Schizophrenia.
Hema Tharoor +5 more
doaj +1 more source
Schizophrenia-mimicking layers outperform conventional neural network layers [PDF]
Frontiers Neurorobot 16, 851471 (2022), 2020 We have reported nanometer-scale three-dimensional studies of brain networks of schizophrenia cases and found that their neurites are thin and tortuous compared to healthy controls. This suggests that connections between distal neurons are suppressed in microcircuits of schizophrenia cases.
arxiv +1 more source