Results 81 to 90 of about 57,972 (301)

Childhood-Onset Schizophrenia: Research Update

, 2001
This review is a research update of recent literature related to childhood-onset schizophrenia (onset of psychotic symptoms by age 12 years). This subgroup of patients has attracted considerable research interest because patients with a childhood onset ...
Patricia Merka, Rachel Augustin, Emilie Nakayama, Sanjiv Kumra, Maryanne Shaw   +4 more
core   +1 more source

A close eye on the eagle-eyed visual acuity hypothesis of autism [PDF]

, 2011
Autism spectrum disorders (ASD) have been associated with sensory hypersensitivity. A recent study reported visual acuity (VA) in ASD in the region reported for birds of prey. The validity of the results was subsequently doubted.
Henrik Walter, Gapp, V., Walter, H., Weber Bernhard, Hainz, D, Poustka Fritz, Ciaramidaro, Angela, Gapp, V, Weber, B, Fritz Poustka, Hainz, D., Schlitt, Sabine, Ciaramidaro Angela, Volker Gapp, Ciaramidaro, A, Weber, Bernhard, Schlitt Sabine, Schirman Shella, Gapp Volker, Hainz Daniela, Schlitt, S, Ciaramidaro, A., Hainz, Daniela, Schirman, S., Christine Freitag, Bolte, S, Walter, Henrik, Shella Schirman, Angela Ciaramidaro, Gapp, Volker, Freitag Christine, Walter, H, Bernhard Weber, Bölte, Sven, Freitag, C, Sabine Schlitt, Schlitt, S., Freitag, Christine M., Poustka, F., Bölte Sven, Daniela Hainz, Walter Henrik, Schirman, S, Schirman, Shella, Weber, B., Freitag, Christine, Sven Bölte, Freitag, C., Poustka, F, Poustka, Fritz   +49 more
core   +1 more source

A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation

Clinical Pharmacology &Therapeutics, EarlyView.
The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix, Sam Mostafa, Amin Rostami‐Hodjegan, Thomas M. Polasek, Carl M. J. Kirkpatrick   +4 more
wiley   +1 more source

Interplay between Schizophrenia Polygenic Risk Score and Childhood Adversity in First-Presentation Psychotic Disorder: A Pilot Study.

PLoS ONE, 2016
A history of childhood adversity is associated with psychotic disorder, with an increase in risk according to number or severity of exposures. However, it is not known why only some exposed individuals go on to develop psychosis.
Antonella Trotta, Conrad Iyegbe, Marta Di Forti, Pak C Sham, Desmond D Campbell, Stacey S Cherny, Valeria Mondelli, Katherine J Aitchison, Robin M Murray, Evangelos Vassos, Helen L Fisher   +10 more
doaj   +1 more source

Psychiatric Morbidity Is Overrepresented in Young Girls at High Risk of Developing Anorexia Nervosa

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Psychiatric comorbidity frequently presents in anorexia nervosa (AN). Yet, the premorbid mental health status is relatively unknown. The aim of this study was to map out psychiatric morbidity and psychopathology among girls at familial high risk (FHR) of developing AN, thereby detecting possible underlying vulnerabilities preceding ...
Karin Dahlin, Kajsa Järvholm, Jovanna Dahlgren, Elisabet Wentz   +3 more
wiley   +1 more source

Mortality in functional seizures: Evidence from a large electronic health records dataset

Epilepsia, EarlyView.
Abstract Objective Several studies have found that people with functional seizures (FS) have increased mortality, approaching that of epilepsy (epileptic seizures [ES]). The small numbers of deaths in these studies make it unclear whether they can be attributed to comorbidities. We used a very large electronic health database to compare mortality in FS
Richard A. Kanaan, Rok Berlot, Tom Pollak, Markus Reuber, Stoyan Popkirov   +4 more
wiley   +1 more source

Childhood Trauma Associated White Matter Abnormalities in First-Episode Schizophrenia [PDF]

, 2018
Schizophrenia is associated with brain connection irregularities within and between brain regions. Childhood trauma increases the risk of schizophrenia suggesting that the relationships between childhood trauma and brain connectivity requires further ...
Seedat, Soraya, Bonginkosi Chiliza, Paola Dazzan, Scheffler, Frederika, Laila Asmal, Sanja Kilian, Jean-Paul Fouche, Kilian, Sanja, Du Plessis, Stefan, Chiliza, Bonginkosi, Soraya Seedat, Dazzan, Paola; id_orcid, Robin Emsley, Frederika Scheffler, Asmal, Laila, Fouche, Jean Paul, Stefan du Plessis, Emsley, Robin   +17 more
core   +1 more source

Long‐term prognosis of pharmacotherapy in newly diagnosed focal epilepsy patients and the predictive value of baseline seizure timing: A prospective cohort study

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a highly heterogeneous neurological disorder with significant prognostic variability. Accurate long‐term outcome prediction remains a clinical challenge. We investigated pharmacotherapeutic prognosis and key predictors, particularly baseline seizure timing, to guide individualized treatment.
Lei Sun, Shouye Sun, Xinyue Zhang, Weihong Lin   +3 more
wiley   +1 more source

Childhood schizophrenia.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1967
No Abstract.
openaire   +4 more sources

Spike detection in the wild: Screening of suspected temporal lobe epilepsy cases using a tailored 2‐channel wearable EEG

Epilepsia Open, EarlyView.
Abstract Objective To clinically validate the contribution of a custom‐built EEG wearable device (waEEG) compared to a full 10–20 electrode array ambulatory EEG (aEEG) for screening epilepsy cases in patients with suspected temporal lobe epilepsy (TLE) but negative routine EEGs. Methods Patients (aged 16–91 years) with clinically suspected TLE who were
Daniel Filipe Borges, Joana Isabel Soares, Daniela Dias, Helena Cordeiro, Alberto Leal   +4 more
wiley   +1 more source