Results 101 to 110 of about 1,025,722 (378)

Comparative genetic architectures of schizophrenia in East Asian and European populations

Nature Genetics, 2018
Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we
Max W. Y. Lam, Chia-Yen Chen, Zhiqiang Li, Alicia R. Martin, J. Bryois, Xixian Ma, Héléna A. Gaspar, M. Ikeda, Beben Benyamin, Brielin C. Brown, Ruize Liu, Wei Zhou, L. Guan, Y. Kamatani, Sung-Wan Kim, M. Kubo, A. Kusumawardhani, Chih-Min Liu, Hong Ma, S. Periyasamy, A. Takahashi, Zhida Xu, Hao Yu, Feng Zhu, Wei J. Chen, Stephen Faraone, S. Glatt, Lin He, S. Hyman, H. Hwu, S. Mccarroll, B. Neale, P. Sklar, D. Wildenauer, Xin Yu, Dai Zhang, B. Mowry, Jimmy Lee, P. Holmans, Shuhua Xu, Patrick F. Sullivan, S. Ripke, M. O’Donovan, M. Daly, Shengying Qin, P. Sham, N. Iwata, K. Hong, S. Schwab, W. Yue, Ming Tsuang, J. Liu, Xiancang Ma, R. Kahn, Yongyong Shi, Hailiang Huang   +55 more
semanticscholar   +1 more source

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

Advanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria, Cristina Iglesias, Sascha Jung, Javier Arcos Hodar, Ruben Nogueiras, Antonio del Sol   +5 more
wiley   +1 more source

Amyloban, extracted from Hericium erinaceus, ameliorates social deficits and suppresses the enhanced dopaminergic system in social defeat stress mice

Neuropsychopharmacology Reports
Social dysfunctions are common in various psychiatric disorders, including depression, schizophrenia, and autism, and are long‐lasting and difficult to treat.
Tianran Wang, Kazuya Toriumi, Kazuhiro Suzuki, Mitsuhiro Miyashita, Azuna Ozawa, Mayuko Masada, Masanari Itokawa, Makoto Arai   +7 more
doaj   +1 more source

Do continuum beliefs reduce schizophrenia stigma? Effects of a laboratory intervention on behavioral and self-reported stigma [PDF]

, 2017
Background and objectives Correlational research shows that belief in a continuum of psychiatric problems predicts decreased public stigma. However, the correlational findings fail to inform the stigma reduction prospects of manipulating continuum ...
Shanks, Lindsay N., Smith, Brian P., Thibodeau, Ryan   +2 more
core   +2 more sources

Multi‐Region Brain Organoids Integrating Cerebral, Mid‐Hindbrain, and Endothelial Systems

Advanced Science, EarlyView.
Multi‐Region Brain Organoids combine cerebral, mid/hindbrain, and endothelial components into an advanced 3D model capturing 80% of fetal brain cellular diversity. This platform reveals essential endothelial‐neural signaling networks that maintain region‐specific intermediate progenitors during hindbrain development.
Anannya Kshirsagar, Hayk Mnatsakanyan, Sai Kulkarni, John Guo, Kai Cheng, Luke Daniel Ofria, Oce Bohra, Ram Sagar, Vasiliki Mahairaki, Christian E Badr, Annie Kathuria   +10 more
wiley   +1 more source

Metacognition in schizophrenia disorders: Comparisons with community controls and bipolar disorder: Replication with a Spanish language Chilean sample [PDF]

, 2018
Metacognition refers to the activities which allow for the availability of a sense of oneself and others in the moment. Research mostly in North America with English-speaking samples has suggested that metacognitive deficits are present in schizophrenia ...
Armijo, Ivan, Ballerini, Massimo, Gagen, Emily C., Irarrázaval, Leonor, Lysaker, Paul H., Mancini, Milena, Stanghellini, Giovanni   +6 more
core   +1 more source

SCRIPT: Predicting Single‐Cell Long‐Range Cis‐Regulation Based on Pretrained Graph Attention Networks

Advanced Science, EarlyView.
SCRIPT is a novel method inferring single‐cell cis‐regulatory relationships (CRRs) from transcriptomic and chromatin accessibility data. SCRIPT incorporates two key innovations: graph causal attention networks supported by empirical CRR evidence, and representation learning enhanced through pretraining on atlas‐scale single‐cell data.
Yu Zhang, Baole Wen, Yifeng Jiao, Yuchen Liu, Xin Guo, Yushuai Wu, Jiyang Li, Limei Han, Yinghui Xu, Xin Gao, Yuan Qi, Yuan Cheng, Ying He, Weidong Tian   +13 more
wiley   +1 more source

Transcriptional evidence of reduced BDNF trophic capacity in the post-mortem human midbrain of schizophrenia cases with high inflammation

Translational Psychiatry
Elevated inflammation in the midbrain of ~45% of people with schizophrenia may relate to altered trophic support for neurons. Dopamine neurons require trophic support from Brain-Derived Neurotrophic Factor (BDNF), that signals via the full-length ...
Jessica J. Chandra, Yunting Zhu, Alice Petty, Yasmine Kostoglou, William X. Haynes, Maree J. Webster, Cynthia S. Weickert   +6 more
doaj   +1 more source

Age differences in mental health literacy [PDF]

, 2015
BACKGROUND: The community's knowledge and beliefs about mental health problems, their risk factors, treatments and sources of help may vary as a function of age. METHODS: Data were taken from an epidemiological survey conducted during 2003–2004 with a
Christensen, Helen, Farrer, Louise, Griffiths, Kathleen M, Jorm, Anthony F, Leach, L. S.   +4 more
core   +1 more source

Levomepromazine for Schizophrenia [PDF]

Schizophrenia Bulletin, 2009
Levomepromazine is an ‘older’ typical antipsychotic licensed for use in schizophrenia but sparingly prescribed in the UK. Our objective is to determine the clinical effects and safety of levomepromazine compared with placebo or antipsychotics for schizophrenia and schizophreniform psychoses.
Mahesh Jayaram, Parthipan Sivaraman, Ranganath D. Rattehalli   +2 more
openaire   +5 more sources