Results 101 to 110 of about 1,069,369 (339)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

Modified Mediterranean Diet for Enrichment of Short Chain Fatty Acids: Potential Adjunctive Therapeutic to Target Immune and Metabolic Dysfunction in Schizophrenia? [PDF]

, 2017
Growing interest in gut and digestive processes and their potential link to brain and peripheral based inflammation or biobehavioral phenotypes has led to an increasing number of basic and translational scientific reports focused on the role of gut ...
Cadenhead, Kristen S, Depp, Colin, Joseph, Jamie, Schmid-Schönbein, Geert, Shih, Pei-An B   +4 more
core   +1 more source

Brain structure, IQ, and psychopathology in young offspring of patients with schizophrenia or bipolar disorder [PDF]

, 2020
Neeltje E.M. van Haren, Nikita Setiaman, Martijn Koevoets, Heleen Baalbergen, René S. Kahn, Manon H. J. Hillegers   +5 more
openalex   +1 more source

Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group

Molecular Psychiatry, 2017
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies.
S. Kelly, N. Jahanshad, A. Zalesky, P. Kochunov, I. Agartz, C. Alloza, O. Andreassen, C. Arango, N. Banaj, S. Bouix, C. Bousman, R. Brouwer, J. Bruggemann, J. Bustillo, W. Cahn, V. Calhoun, D. Cannon, V. Carr, S. Catts, J. Chen, J.X. Chen, X. Chen, C. Chiapponi, K. K. Cho, V. Ciullo, A. Corvin, B. Crespo-Facorro, V. Cropley, P. de Rossi, C. Díaz-Caneja, E. Dickie, S. Ehrlich, F. Fan, Joshua Faskowitz, H. Fatouros-Bergman, L. Flyckt, J. Ford, J. Fouche, M. Fukunaga, M. Gill, D. Glahn, R. Gollub, E. Goudzwaard, H. Guo, R. Gur, R. Gur, T. Gurholt, R. Hashimoto, S. Hatton, F. Henskens, D. Hibar, I. Hickie, L. Hong, J. Horáček, F. Howells, H. H. Hulshoff Pol, C. Hyde, D. Isaev, A. Jablensky, P. Jansen, J. Janssen, E. Jönsson, L. Jung, R. Kahn, Z. Kikinis, K. Liu, P. Klauser, C. Knöchel, M. Kubicki, J. Lagopoulos, C. Langen, S. Lawrie, R. Lenroot, K. Lim, C. López-Jaramillo, A. Lyall, V. Magnotta, R. Mandl, D. Mathalon, R. McCarley, S. McCarthy-Jones, C. Mcdonald, S. McEwen, A. McIntosh, T. Melicher, R. Mesholam-Gately, P. Michie, B. Mowry, B. Mueller, D. Newell, P. O’Donnell, V. Oertel-Knöchel, L. Oestreich, S. Paciga, C. Pantelis, O. Pasternak, G. Pearlson, G. Pellicanò, A. Pereira, J. P. Pineda Zapata, F. Piras, S. Potkin, Adrian Preda, P. Rasser, D. Roalf, R. Roiz, A. Roos, D. Rotenberg, T. Satterthwaite, P. Savadjiev, U. Schall, R. Scott, M. Seal, L. Seidman, C. Shannon Weickert, C. Whelan, M. Shenton, J. Kwon, G. Spalletta, F. Španiel, E. Sprooten, M. Stäblein, Dan J Stein, S. Sundram, Y. Tan, S. Tan, S. Tang, H. Temmingh, L. Westlye, S. Tønnesen, D. Tordesillas-Gutiérrez, N. T. Doan, J. Vaidya, N. V. van Haren, C. Vargas, D. Vecchio, D. Velakoulis, A. Voineskos, J. Voyvodic, Z. Wang, P. Wan, D. Wei, T. Weickert, H. Whalley, T. White, T. Whitford, J. Wojcik, H. Xiang, Z. Xie, H. Yamamori, F. Yang, N. Yao, G. Zhang, J. Zhao, T. V. van Erp, J. Turner, P. Thompson, G. Donohoe   +157 more
semanticscholar   +1 more source

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

Advanced Science, EarlyView.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan, Wentao Gong, Xiaodian Cai, Jinyan Teng, Jiali Cai, Haonan Zeng, Wondossen Ayalew, Qingpeng Shen, Zhanming Zhong, Yifei Wang, Wenjing Zhang, Yuhan Tian, Dantong Xu, Yahui Gao, Hongwei Yin, Yuebo Zhang, Jiahui Hou, Tianru Zhou, Jiaqi Li, Lingzhao Fang, Xiaolong Yuan, Zhe Zhang   +21 more
wiley   +1 more source

Peripheral Lipid Signatures, Metabolic Dysfunction, and Pathophysiology in Schizophrenia Spectrum Disorders

Metabolites
Metabolic dysfunction is commonly observed in schizophrenia spectrum disorders (SSDs). The causes of metabolic comorbidity in SSDs are complex and include intrinsic or biological factors linked to the disorder, which are compounded by antipsychotic (AP ...
Sally Wu, Kristoffer J. Panganiban, Jiwon Lee, Dan Li, Emily C.C. Smith, Kateryna Maksyutynska, Bailey Humber, Tariq Ahmed, Sri Mahavir Agarwal, Kristen Ward, Margaret Hahn   +10 more
doaj   +1 more source

Neural response to specific components of fearful faces in healthy and schizophrenic adults [PDF]

, 2009
Perception of fearful faces is associated with functional activation of cortico-limbic structures, which has been found altered in individuals with psychiatric disorders such as schizophrenia, autism and major depression.
Brammer, Michael J., David, Anthony S., El-Hage, Wissam, Giampietro, Vincent, Kalidindi, Sridevi, Lawrence, Natalia, Marshall, Nicolette, McDonald, Colm, Phillips, Mary L., Radua, Joaquim, Russell, Tamara, Surguladze, Simon A.   +11 more
core   +1 more source

Cognitive impairment among an Egyptian sample of patients with schizophrenia and bipolar disorders: a comparative study [PDF]

, 2023
Eman M. Khedr, Nashwa E. Ghanima, Khaled Elbeh, Gellan K. Ahmed, Bastawy El-Fawal   +4 more
openalex   +1 more source

Who puts the “support” in supportive housing? The relationship between housing staff support and resident experiences, and the potential moderating role of self‐determination

American Journal of Community Psychology, EarlyView.
Abstract The provision of residential and community‐based services for individuals with serious mental illness (SMI) has become increasingly important following the deinstitutionalization movement. Much of the existing research on supportive housing focuses on housing outcomes rather than exploring how the program helps its residents thrive in the ...
Kenna E. Dickard, Greg Townley
wiley   +1 more source