Results 31 to 40 of about 1,004,261 (415)

Nuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines

Journal of Neuroinflammation, 2020
Background High inflammation status despite an absence of known infection characterizes a subpopulation of people with schizophrenia who suffer from more severe cognitive deficits, less cortical grey matter, and worse neuropathology. Transcripts encoding
Caitlin E. Murphy, Adam J. Lawther, Maree J. Webster, Makoto Asai, Yuji Kondo, Mitsuyuki Matsumoto, Adam K. Walker, Cynthia Shannon Weickert   +7 more
doaj   +1 more source

Cannabidiol versus risperidone for treatment of recent-onset psychosis with comorbid cannabis use: study protocol for a randomized controlled clinical trial

BMC Psychiatry, 2021
Background Cannabis use is an important risk factor for development of psychosis and further transition to schizophrenia. The prevalence of patients with psychosis and comorbid cannabis use (dual diagnosis) is rising with no approved specialized ...
Jesper Østrup Rasmussen, Poul Jennum, Kristian Linnet, Birte Y. Glenthøj, Lone Baandrup   +4 more
doaj   +1 more source

Novel Schizophrenia Risk Gene TCF4 Influences Verbal Learning and Memory Functioning in Schizophrenia Patients [PDF]

, 2011
Background: Recently, a role of the transcription factor 4 (TCF4) gene in schizophrenia has been reported in a large genome-wide association study. It has been hypothesized that TCF4 affects normal brain development and TCF4 has been related to different
Aleman A, Anna Schuhmacher, Bogerts B, Dan Rujescu, Hans-Jürgen Möller, Heinz Häfner, Ingo Frommann, Leonhard Lennertz, Martin W. Landsberg, Michael Wagner, Petra Franke, Pitt D, Rainald Mössner, Saykin AJ, Stefánsson H, Svenja Schulze-Rauschenbach, Whyte MC, Wolfgang Gaebel, Wolfgang Maier, Wolfgang Wölwer, Wright IC   +20 more
core   +1 more source

Negative Symptoms in Schizophrenia: A Review and Clinical Guide for Recognition, Assessment, and Treatment

Neuropsychiatric Disease and Treatment, 2020
Schizophrenia is frequently a chronic and disabling disorder, characterized by heterogeneous positive and negative symptom constellations. The objective of this review was to provide information that may be useful for clinicians treating patients with ...
C. Correll, N. Schooler
semanticscholar   +1 more source

Using blood cytokine measures to define high inflammatory biotype of schizophrenia and schizoaffective disorder

Journal of Neuroinflammation, 2017
Background Increases in pro-inflammatory cytokines are found in the brain and blood of people with schizophrenia. However, increased cytokines are not evident in all people with schizophrenia, but are found in a subset.
Danny Boerrigter, Thomas W. Weickert, Rhoshel Lenroot, Maryanne O’Donnell, Cherrie Galletly, Dennis Liu, Martin Burgess, Roxanne Cadiz, Isabella Jacomb, Vibeke S. Catts, Stu G. Fillman, Cynthia Shannon Weickert   +11 more
doaj   +1 more source

Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia

medRxiv, 2020
Schizophrenia is a psychiatric disorder whose pathophysiology is largely unknown. It has a heritability of 60-80%, much of which is attributable to common risk alleles, suggesting genome-wide association studies can inform our understanding of aetiology.
S. Ripke, J. Walters, M. O’Donovan
semanticscholar   +1 more source

Rethinking Schizophrenia in the Context of Normal Neurodevelopment

Frontiers in Cellular Neuroscience, 2013
The schizophrenia brain is differentiated from the normal brain by subtle changes, with significant overlap in measures between normal and disease states. For the past 25 years, schizophrenia has increasingly been considered a neurodevelopmental disorder.
Vibeke Sorensen Catts, Vibeke Sorensen Catts, Vibeke Sorensen Catts, Samantha Jane Fung, Samantha Jane Fung, Samantha Jane Fung, Leonora Elizabeth Long, Leonora Elizabeth Long, Leonora Elizabeth Long, Dispesh eJoshi, Dispesh eJoshi, Dispesh eJoshi, Ans eVercammen, Ans eVercammen, Ans eVercammen, Ans eVercammen, Katherine Margaret Allen, Katherine Margaret Allen, Katherine Margaret Allen, Stu Gregory Fillman, Stu Gregory Fillman, Stu Gregory Fillman, Loretta eMoore, Debora eRothmond, Debora eRothmond, Duncan eSinclair, Duncan eSinclair, Duncan eSinclair, Yash eTiwari, Yash eTiwari, Yash eTiwari, Shan-Yuan eTsai, Shan-Yuan eTsai, Shan-Yuan eTsai, Thomas Wesley Weickert, Thomas Wesley Weickert, Thomas Wesley Weickert, Cynthia eShannon Weickert, Cynthia eShannon Weickert, Cynthia eShannon Weickert   +39 more
doaj   +1 more source

Morbidity burden and community-based palliative care are associated with rates of hospital use by people with schizophrenia in the last year of life: A population-based matched cohort study [PDF]

, 2018
Objective: People with schizophrenia face an increased risk of premature death from chronic diseases and injury. This study describes the trajectory of acute care health service use in the last year of life for people with schizophrenia and how this ...
Arendts, Glenn, Brameld, Kate, Kelly, Brian, Rosenwax, Lorna, Spilsbury, Katrina   +4 more
core   +5 more sources

Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia

Frontiers in Immunology, 2020
Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a dopamine neuron-rich region associated with schizophrenia symptoms.
Tertia D. Purves-Tyson, Tertia D. Purves-Tyson, Kate Robinson, Amelia M. Brown, Danny Boerrigter, Helen Q. Cai, Helen Q. Cai, Christin Weissleder, Samantha J. Owens, Debora A. Rothmond, Cynthia Shannon Weickert, Cynthia Shannon Weickert, Cynthia Shannon Weickert   +12 more
doaj   +1 more source

Schizophrenia research under the framework of predictive coding: body, language, and others [PDF]

arXiv, 2023
Although there have been so many studies on schizophrenia under the framework of predictive coding, works focusing on treatment are very preliminary. A model-oriented, operationalist, and comprehensive understanding of schizophrenia would promote the therapy turn of further research. We summarize predictive coding models of embodiment, co-occurrence of
arxiv