Pdxdc1 modulates prepulse inhibition of acoustic startle in the mouse. [PDF]
, 2017 Current antipsychotic medications used to treat schizophrenia all target the dopamine D2 receptor. Although these drugs have serious side effects and limited efficacy, no novel molecular targets for schizophrenia treatment have been successfully ...
Boutros, PC +5 more
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Abnormal Task Modulation of Oscillatory Neural Activity in Schizophrenia
Frontiers in Psychology, 2013 Schizophrenia patients have deficits in cognitive function that are a core feature of the disorder. AX-CPT is commonly used to study cognition in schizophrenia, and patients have characteristic pattern of behavioral and ERP response.
Elisa C Dias +6 more
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Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia
Frontiers in Immunology, 2020 Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a dopamine neuron-rich region associated with schizophrenia symptoms.
Tertia D. Purves-Tyson +12 more
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Gross Domestic Product (GDP) and productivity of schizophrenia trials: an ecological study [PDF]
, 2003 The 5000 randomised controlled trials (RCTs) in the Cochrane Schizophrenia Group's database affords an opportunity to research for variables related to the differences between nations of their output of schizophrenia trials.
B Thornley +11 more
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Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia
medRxiv, 2020 Schizophrenia is a psychiatric disorder whose pathophysiology is largely unknown. It has a heritability of 60-80%, much of which is attributable to common risk alleles, suggesting genome-wide association studies can inform our understanding of aetiology.
S. Ripke, J. Walters, M. O’Donovan
semanticscholar +1 more source
Alterations in functional brain network structure induced by subchronic phencyclidine (PCP) treatment parallel those seen in schizophrenia [PDF]
, 2010 of poster presentation shown at the 2nd Biennial Schizophrenia International Research Conference on Alterations in functional brain network structure induced by subchronic phencyclidine (PCP) treatment parallel those seen in ...
Dawson, Neil +3 more
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A novel DRD2 single-nucleotide polymorphism associated with schizophrenia predicts age of onset: HapMap tag-sincle-nucleotide polymorphism analysis [PDF]
, 2012 Background: Dopamine D2 receptor (DRD2) is thought to be critical in regulating the dopaminergic pathway in the brain which is known to be important in the aetiology of schizophrenia. It is therefore not surprising that most antipsychotic medication acts
Hughes, Ian +5 more
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Biological Psychiatry Global Open Science, 2023 Background: Findings of reward disturbances in unaffected relatives of patients with schizophrenia suggest reward disturbances as an endophenotype for schizophrenia.
Mette Ødegaard Nielsen +8 more
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Residual negative symptoms differentiate cognitive performance in clinically stable patients with schizophrenia and bipolar disorder [PDF]
, 2014 Cognitive deficits in various domains have been shown in patients with bipolar disorder and schizophrenia. The purpose of the present study was to examine if residual psychopathology explained the difference in cognitive function between clinically ...
Krishnadas, Rajeev +4 more
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Schizophrenia, social practices and cultural values: A conceptual introduction [PDF]
, 2018 Schizophrenia is usually described as a fragmentation of subjective experience and the impossibility to engage in meaningful cultural and intersubjective practices. Although the term schizophrenia is less than 100 years old, madness is generally believed
Gonçalves, J. +2 more
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