Results 31 to 40 of about 821,521 (329)

Nuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines

Journal of Neuroinflammation, 2020
Background High inflammation status despite an absence of known infection characterizes a subpopulation of people with schizophrenia who suffer from more severe cognitive deficits, less cortical grey matter, and worse neuropathology. Transcripts encoding
Caitlin E. Murphy, Adam J. Lawther, Maree J. Webster, Makoto Asai, Yuji Kondo, Mitsuyuki Matsumoto, Adam K. Walker, Cynthia Shannon Weickert   +7 more
doaj   +1 more source

Cannabidiol versus risperidone for treatment of recent-onset psychosis with comorbid cannabis use: study protocol for a randomized controlled clinical trial

BMC Psychiatry, 2021
Background Cannabis use is an important risk factor for development of psychosis and further transition to schizophrenia. The prevalence of patients with psychosis and comorbid cannabis use (dual diagnosis) is rising with no approved specialized ...
Jesper Østrup Rasmussen, Poul Jennum, Kristian Linnet, Birte Y. Glenthøj, Lone Baandrup   +4 more
doaj   +1 more source

Schizophrenia in older adults [PDF]

, 2011
Although the number of persons over the age of 55 with schizophrenia is expected to double over the next 20 years, the research data on older people with schizophrenia is limited.
American Psychiatric Association, Bleuler, Bleuler, Bridge, Collier, Collier, Collier, Elizabeth Collier, Jeanne M. Sorrell, Palmer, Roth, Snowden, World Health Organization   +12 more
core   +2 more sources

Using blood cytokine measures to define high inflammatory biotype of schizophrenia and schizoaffective disorder

Journal of Neuroinflammation, 2017
Background Increases in pro-inflammatory cytokines are found in the brain and blood of people with schizophrenia. However, increased cytokines are not evident in all people with schizophrenia, but are found in a subset.
Danny Boerrigter, Thomas W. Weickert, Rhoshel Lenroot, Maryanne O’Donnell, Cherrie Galletly, Dennis Liu, Martin Burgess, Roxanne Cadiz, Isabella Jacomb, Vibeke S. Catts, Stu G. Fillman, Cynthia Shannon Weickert   +11 more
doaj   +1 more source

Novel Schizophrenia Risk Gene TCF4 Influences Verbal Learning and Memory Functioning in Schizophrenia Patients [PDF]

, 2011
Background: Recently, a role of the transcription factor 4 (TCF4) gene in schizophrenia has been reported in a large genome-wide association study. It has been hypothesized that TCF4 affects normal brain development and TCF4 has been related to different
Aleman A, Anna Schuhmacher, Bogerts B, Dan Rujescu, Hans-Jürgen Möller, Heinz Häfner, Ingo Frommann, Leonhard Lennertz, Martin W. Landsberg, Michael Wagner, Petra Franke, Pitt D, Rainald Mössner, Saykin AJ, Stefánsson H, Svenja Schulze-Rauschenbach, Whyte MC, Wolfgang Gaebel, Wolfgang Maier, Wolfgang Wölwer, Wright IC   +20 more
core   +1 more source

Unseen Affective Faces Influence Person Perception Judgments in Schizophrenia. [PDF]

, 2014
To demonstrate the influence of unconscious affective processing on consciously processed information among people with and without schizophrenia, we used a continuous flash suppression (CFS) paradigm to examine whether early and rapid processing of ...
Barrett, Lisa Feldman, Kring, Ann M, Siegel, Erika H   +2 more
core   +1 more source

Rethinking Schizophrenia in the Context of Normal Neurodevelopment

Frontiers in Cellular Neuroscience, 2013
The schizophrenia brain is differentiated from the normal brain by subtle changes, with significant overlap in measures between normal and disease states. For the past 25 years, schizophrenia has increasingly been considered a neurodevelopmental disorder.
Vibeke Sorensen Catts, Vibeke Sorensen Catts, Vibeke Sorensen Catts, Samantha Jane Fung, Samantha Jane Fung, Samantha Jane Fung, Leonora Elizabeth Long, Leonora Elizabeth Long, Leonora Elizabeth Long, Dispesh eJoshi, Dispesh eJoshi, Dispesh eJoshi, Ans eVercammen, Ans eVercammen, Ans eVercammen, Ans eVercammen, Katherine Margaret Allen, Katherine Margaret Allen, Katherine Margaret Allen, Stu Gregory Fillman, Stu Gregory Fillman, Stu Gregory Fillman, Loretta eMoore, Debora eRothmond, Debora eRothmond, Duncan eSinclair, Duncan eSinclair, Duncan eSinclair, Yash eTiwari, Yash eTiwari, Yash eTiwari, Shan-Yuan eTsai, Shan-Yuan eTsai, Shan-Yuan eTsai, Thomas Wesley Weickert, Thomas Wesley Weickert, Thomas Wesley Weickert, Cynthia eShannon Weickert, Cynthia eShannon Weickert, Cynthia eShannon Weickert   +39 more
doaj   +1 more source

Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia

Frontiers in Immunology, 2020
Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a dopamine neuron-rich region associated with schizophrenia symptoms.
Tertia D. Purves-Tyson, Tertia D. Purves-Tyson, Kate Robinson, Amelia M. Brown, Danny Boerrigter, Helen Q. Cai, Helen Q. Cai, Christin Weissleder, Samantha J. Owens, Debora A. Rothmond, Cynthia Shannon Weickert, Cynthia Shannon Weickert, Cynthia Shannon Weickert   +12 more
doaj   +1 more source

Pdxdc1 modulates prepulse inhibition of acoustic startle in the mouse. [PDF]

, 2017
Current antipsychotic medications used to treat schizophrenia all target the dopamine D2 receptor. Although these drugs have serious side effects and limited efficacy, no novel molecular targets for schizophrenia treatment have been successfully ...
Boutros, PC, Feldcamp, LA, Fletcher, PJ, Nobrega, JN, Raymond, R, Wong, AHC   +5 more
core   +1 more source

Abnormal Task Modulation of Oscillatory Neural Activity in Schizophrenia

Frontiers in Psychology, 2013
Schizophrenia patients have deficits in cognitive function that are a core feature of the disorder. AX-CPT is commonly used to study cognition in schizophrenia, and patients have characteristic pattern of behavioral and ERP response.
Elisa C Dias, Stephan eBickel, Michael L Epstein, Pejman eSehatpour, Pejman eSehatpour, Daniel C Javitt, Daniel C Javitt   +6 more
doaj   +1 more source