Results 51 to 60 of about 620,945 (334)

Striatal Volume Increase After Six Weeks of Selective Dopamine D2/3 Receptor Blockade in First-Episode, Antipsychotic-Naïve Schizophrenia Patients

Frontiers in Neuroscience, 2020
Patients with chronic schizophrenia often display enlarged striatal volumes, and antipsychotic drugs may contribute via the dopamine D2/3 receptor (D2/3R) blockade.
Helle G. Andersen, Helle G. Andersen, Jayachandra M. Raghava, Jayachandra M. Raghava, Claus Svarer, Sanne Wulff, Louise B. Johansen, Patrick K. Antonsen, Patrick K. Antonsen, Mette Ø. Nielsen, Mette Ø. Nielsen, Egill Rostrup, Anthony C. Vernon, Anthony C. Vernon, Lars T. Jensen, Lars H. Pinborg, Birte Y. Glenthøj, Birte Y. Glenthøj, Bjørn H. Ebdrup, Bjørn H. Ebdrup   +19 more
doaj   +1 more source

Differential expression of diacylglycerol kinase ζ is involved in inferior parietal lobule-related dysfunction in schizophrenia with cognitive impairments

BMC Psychiatry, 2023
Background Cognitive impairment is the main factor in the poor prognosis of schizophrenia, but its mechanism remains unclear. The inferior parietal lobule (IPL) is related to various clinical symptoms and cognitive impairment in schizophrenia.
Xiao-Fan Liu, Shu-Wan Zhao, Jin-Jin Cui, Yue-Wen Gu, Jing-Wen Fan, Yu-Fei Fu, Ya-Hong Zhang, Hong Yin, Kun Chen, Long-Biao Cui   +9 more
doaj   +1 more source

Perceptual Bias in Motion Discrimination is Related to Asymmetric Interhemispheric Alpha Traveling Waves

Advanced Science, EarlyView.
The study shows an asymmetric connectivity between visual motion areas, with alpha travelling waves favouring left‐to‐right (thick red arrow) over right‐to‐left (thin blue arrow) communication. This asymmetry predicts a bias toward reporting leftward (higher number of red dots) over rightward (lower number of blue dots) motion direction, regardless of ...
Luca Tarasi, Andrea Alamia, Vincenzo Romei   +2 more
wiley   +1 more source

H2O2‐Activated Serotonin Precursor Probe for Mapping Neuronal Redox Homeostasis Reveals 5‐HT Interactions with Neighboring Proteins Under Oxidative Stress

Advanced Science, EarlyView.
HOP, an innovative ICT‐based fluorescent probe, visualizes H2O2 in stressed neurons while locally releasing serotonin (5‐HT) for real‐time protein interaction mapping. Its unique tandem sensing and labeling strategy reveals 5‐HT's role under oxidative stress, offering a powerful tool for neurophysiological research and therapeutic discovery.
Yani Liu, Jiwen Yuan, Tuanjie Zhang, Xinyi Cai, Meng Xu, Xueao Wang, Rui Wang, Bing Zhang, Hai‐Liang Zhu, Yong Qian   +9 more
wiley   +1 more source

BDNF and the maturation of posttranscriptional regulatory networks in human SH-SY5Y neuroblast differentiation

Frontiers in Cellular Neuroscience, 2014
The SH-SY5Y culture system is a convenient neuronal model with the potential to elaborate human/primate-specific transcription networks and pathways related to human cognitive disorders.
Belinda J Goldie, Belinda J Goldie, Michelle M Barnett, Murray J Cairns, Murray J Cairns   +4 more
doaj   +1 more source

Obsessive-compulsive symptoms moderates the effects of cognitive functioning on quality of life in clozapine-treated schizophrenia

Psychiatry Research Communications, 2022
Obsessive-compulsive symptoms (OCS) are frequently reported in clozapine-treated schizophrenia. Studies on the effects of OCS on cognitive abilities and quality of life (QoL) yielded contrasting results, ranging from benefits to adverse effects.
Giulia Agostoni, Margherita Bechi, Mariachiara Buonocore, Federica Cuoco, Jacopo Sapienza, Marco Spangaro, Francesca Martini, Federica Cocchi, Ilaria Ferri, Filippo Cantù, Roberto Cavallaro, Marta Bosia   +11 more
doaj   +1 more source

Nonsocial and social cognition in schizophrenia: current evidence and future directions

World Psychiatry, 2019
Cognitive impairment in schizophrenia involves a broad array of nonsocial and social cognitive domains. It is a core feature of the illness, and one with substantial implications for treatment and prognosis.
Michael F. Green, W. Horan, Junghee Lee
semanticscholar   +1 more source

SCRIPT: Predicting Single‐Cell Long‐Range Cis‐Regulation Based on Pretrained Graph Attention Networks

Advanced Science, EarlyView.
SCRIPT is a novel method inferring single‐cell cis‐regulatory relationships (CRRs) from transcriptomic and chromatin accessibility data. SCRIPT incorporates two key innovations: graph causal attention networks supported by empirical CRR evidence, and representation learning enhanced through pretraining on atlas‐scale single‐cell data.
Yu Zhang, Baole Wen, Yifeng Jiao, Yuchen Liu, Xin Guo, Yushuai Wu, Jiyang Li, Limei Han, Yinghui Xu, Xin Gao, Yuan Qi, Yuan Cheng, Ying He, Weidong Tian   +13 more
wiley   +1 more source

Identifying gene expression profiles associated with neurogenesis and inflammation in the human subependymal zone from development through aging

Scientific Reports, 2022
The generation of new neurons within the mammalian forebrain continues throughout life within two main neurogenic niches, the subgranular zone (SGZ) of the hippocampal dentate gyrus, and the subependymal zone (SEZ) lining the lateral ventricles.
Mainá Bitar, Christin Weissleder, Hayley F. North, Misaki S. Clearwater, Oressia Zalucki, Glenda M. Halliday, Maree J. Webster, Michael Piper, Cynthia Shannon Weickert, Guy Barry   +9 more
doaj   +1 more source

Association of Cognitive Impairment With Anhedonia in Patients With Schizophrenia

Frontiers in Psychiatry, 2021
Anhedonia is considered as one of the five dimensions of negative symptoms and mainly refers to the reduction of the capacity of feeling pleasure.
Lingfang Yu, Hua Ni, Zenan Wu, Xinyu Fang, Yan Chen, Dandan Wang, Chen Zhang   +6 more
doaj   +1 more source