Results 61 to 70 of about 620,945 (334)

Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics

Advanced Science, EarlyView.
Muralidharan and colleagues develop cell‐type‐specific transcriptomic aging clocks using single‐nucleus RNA sequencing of human post mortem prefrontal cortex samples. These clocks accurately predict age and identify distinct aging trajectories in specific brain cell types.
Chandramouli Muralidharan, Enikő Zakar‐Polyák, Anita Adami, Anna A. Abbas, Yogita Sharma, Raquel Garza, Jenny G. Johansson, Diahann A. M. Atacho, Éva Renner, Miklós Palkovits, Csaba Kerepesi, Johan Jakobsson, Karolina Pircs   +12 more
wiley   +1 more source

The effect of training intensity on implicit learning rates in schizophrenia

Scientific Reports, 2021
Cognitive impairments in learning and memory are core symptoms of schizophrenia, associated with reduced self-reported quality of life. The most effective treatment of cognitive impairments is drill and practice cognitive training.
Natasza D. Orlov, Jessica Sanderson, Syed Ali Muqtadir, Anastasia K. Kalpakidou, Panayiota G. Michalopoulou, Jie Lu, Sukhi S. Shergill   +6 more
doaj   +1 more source

Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia

Nature Neuroscience, 2016
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral prefrontal cortex of people with schizophrenia (N = 258) and control subjects (
M. Fromer, P. Roussos, S. Sieberts, Jessica S. Johnson, D. Kavanagh, T. Perumal, D. Ruderfer, Edwin C. T. Oh, A. Topol, H. Shah, L. Klei, R. Kramer, D. Pinto, Z. Gümüş, A. E. Cicek, Kristen K. Dang, A. Browne, Cong Lu, Lu Xie, B. Readhead, E. Stahl, Jianqiu Xiao, Mahsa Parvisi, T. Hamamsy, J. Fullard, Ying-Chih Wang, M. Mahajan, J. Derry, J. Dudley, S. Hemby, Benjamin A. Logsdon, K. Talbot, T. Raj, T. Raj, D. Bennett, P. D. Jager, P. D. Jager, Jun Zhu, Bin Zhang, Patrick F. Sullivan, Patrick F. Sullivan, A. Chess, S. Purcell, L. Shinobu, L. Mangravite, Hiroyoshi Toyoshiba, R. Gur, C. Hahn, D. Lewis, V. Haroutunian, M. Peters, B. Lipska, J. Buxbaum, E. Schadt, K. Hirai, K. Roeder, K. Brennand, N. Katsanis, E. Domenici, B. Devlin, P. Sklar   +60 more
semanticscholar   +1 more source

Allele‐Specific Regulation of PAXIP1‐AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice

Advanced Science, EarlyView.
This study identifies a functional noncoding variant, rs112651172 (C/G), that drives allele‐specific expression of PAXIP1‐AS1 in monozygotic twin pairs discordant for schizophrenia and bipolar disorder. The risk G allele enhances CEBPB binding, leading to lncRNA upregulation, CNTNAP3 derepression, and synaptic and behavioral deficits in mice.
Chaoying Ni, He Chen, Qiaqi Chen, Yangyang Liao, Yunqian Wang, Linyan Ye, Xiaohui Wu, Hongyu Ni, Tingyun Jiang, Shufen Li, Qiong Yang, Hong Xue, Zhongju Wang, Feng Yi, Cunyou Zhao   +14 more
wiley   +1 more source

Amyloban, extracted from Hericium erinaceus, ameliorates social deficits and suppresses the enhanced dopaminergic system in social defeat stress mice

Neuropsychopharmacology Reports
Social dysfunctions are common in various psychiatric disorders, including depression, schizophrenia, and autism, and are long‐lasting and difficult to treat.
Tianran Wang, Kazuya Toriumi, Kazuhiro Suzuki, Mitsuhiro Miyashita, Azuna Ozawa, Mayuko Masada, Masanari Itokawa, Makoto Arai   +7 more
doaj   +1 more source

A Systematic Review of the Prevalence of Schizophrenia

PLoS Medicine, 2005
Background Understanding the prevalence of schizophrenia has important implications for both health service planning and risk factor epidemiology. The aims of this review are to systematically identify and collate studies describing the prevalence of ...
S. Saha, D. Chant, J. Welham, J. Mcgrath
semanticscholar   +1 more source

Analyses of GWAS and Sub‐Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk

Advanced Science, EarlyView.
A cost‐effective strategy is developed analyzing sub‐threshold GWAS loci (5 × 10−8 < P ≤ 10−6), identifying 180 risk loci and 304 high‐confidence genes through combined GWAS/subGWAS analysis. This approach reveals dendrite development and morphogenesis (DDM) as a novel SCZ pathway.
Rui Chen, Benjamin Siciliano, Quan Wang, Chongchong Xu, Qiang Wei, Hai Yang, James S Sutcliffe, Yi Jiang, Ying Ji, Chunyu Liu, Feixiong Cheng, Edwin H Cook, Nancy J Cox, Xue Zhong, Zhexing Wen, Bingshan Li   +15 more
wiley   +1 more source

Transcriptional evidence of reduced BDNF trophic capacity in the post-mortem human midbrain of schizophrenia cases with high inflammation

Translational Psychiatry
Elevated inflammation in the midbrain of ~45% of people with schizophrenia may relate to altered trophic support for neurons. Dopamine neurons require trophic support from Brain-Derived Neurotrophic Factor (BDNF), that signals via the full-length ...
Jessica J. Chandra, Yunting Zhu, Alice Petty, Yasmine Kostoglou, William X. Haynes, Maree J. Webster, Cynthia S. Weickert   +6 more
doaj   +1 more source

Comparative genetic architectures of schizophrenia in East Asian and European populations

Nature Genetics, 2018
Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we
Max W. Y. Lam, Chia-Yen Chen, Zhiqiang Li, Alicia R. Martin, J. Bryois, Xixian Ma, Héléna A. Gaspar, M. Ikeda, Beben Benyamin, Brielin C. Brown, Ruize Liu, Wei Zhou, L. Guan, Y. Kamatani, Sung-Wan Kim, M. Kubo, A. Kusumawardhani, Chih-Min Liu, Hong Ma, S. Periyasamy, A. Takahashi, Zhida Xu, Hao Yu, Feng Zhu, Wei J. Chen, Stephen Faraone, S. Glatt, Lin He, S. Hyman, H. Hwu, S. Mccarroll, B. Neale, P. Sklar, D. Wildenauer, Xin Yu, Dai Zhang, B. Mowry, Jimmy Lee, P. Holmans, Shuhua Xu, Patrick F. Sullivan, S. Ripke, M. O’Donovan, M. Daly, Shengying Qin, P. Sham, N. Iwata, K. Hong, S. Schwab, W. Yue, Ming Tsuang, J. Liu, Xiancang Ma, R. Kahn, Yongyong Shi, Hailiang Huang   +55 more
semanticscholar   +1 more source

MRI Epicenters Differentiate Spatiotemporal Patterns of Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
A connectivity‐based MRI epicenter model identifies two Parkinson's disease subtypes: subtype 1 with infratentorial‐dominant epicenters, severe motor symptoms, and rapid progression; and subtype 2 with supratentorial‐dominant epicenters with mild progression.
Xiaojie Duanmu, Zihao Zhu, Jiaqi Wen, Jianmei Qin, Qianshi Zheng, Weijin Yuan, Yingni Jin, Nan Lu, Lu Wang, Cheng Zhou, Tao Guo, Haoting Wu, Chenqing Wu, Ziyi Zhu, Lifang Wang, Jingwen Chen, Jingjing Wu, Bingting Zhu, Yuelin Fang, Yaping Yan, Baorong Zhang, Minming Zhang, Xiaojun Guan, Xiaojun Xu   +23 more
wiley   +1 more source