Results 81 to 90 of about 1,069,369 (339)

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Amyloban, extracted from Hericium erinaceus, ameliorates social deficits and suppresses the enhanced dopaminergic system in social defeat stress mice

Neuropsychopharmacology Reports
Social dysfunctions are common in various psychiatric disorders, including depression, schizophrenia, and autism, and are long‐lasting and difficult to treat.
Tianran Wang, Kazuya Toriumi, Kazuhiro Suzuki, Mitsuhiro Miyashita, Azuna Ozawa, Mayuko Masada, Masanari Itokawa, Makoto Arai   +7 more
doaj   +1 more source

Psychosocial and Biological Factors Contributing to Body Weight Gain in Schizophrenia [PDF]

, 2011
Overweight and obesity are frequently reported to be a significant issue in schizophrenia resulting in the inherent complications of these disorders.
Pai, NB, Vella, SC
core   +2 more sources

Health-related quality of life, adiposity, and sedentary behavior in patients with early schizophrenia: Preliminary study [PDF]

, 2012
Objective: To examine adiposity and sedentary behavior in relation to health-related quality of life (QoL) in patients with early schizophrenia. Methods: A cross-sectional study was used to assess adiposity by dual-energy X-ray absorptiometry scans ...
Brar, JS, Ganguli, R, Strassnig, M
core   +1 more source

Morphological and Hyperphosphorylation Transitions of Nanoscale Tau Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
Super‐resolution microscopy identifies nano‐sized tau aggregates (nano‐aggregates) and reveals distinct transitions in their morphology and phosphorylation profiles across control, Primary Age‐Related Tauopathy, and Alzheimer's disease brains. Morphology and hyperphosphorylation signatures distinguish physiological from pathological forms, with nano ...
Adriana N. Santiago‐Ruiz, Siewert Hugelier, Gabriela L. Correa, Charles R. Bond, Edward B. Lee, Melike Lakadamyali   +5 more
wiley   +1 more source

Epidural auditory event-related potentials in the rat to frequency and duration deviants: evidence of mismatch negativity?

Frontiers in Psychology, 2011
The capacity of the human brain to detect deviance in the acoustic environment pre-attentively is reflected in a brain event-related potential (ERP), mismatch negativity (MMN).
Tamo eNakamura, Tamo eNakamura, Tamo eNakamura, Tamo eNakamura, Patricia T Michie, Patricia T Michie, Patricia T Michie, Patricia T Michie, William R Fulham, William R Fulham, William R Fulham, William R Fulham, Juanita eTodd, Juanita eTodd, Juanita eTodd, Juanita eTodd, Timothy W Budd, Timothy W Budd, Timothy W Budd, Timothy W Budd, Ulrich eSchall, Ulrich eSchall, Ulrich eSchall, Ulrich eSchall, Michael eHunter, Michael eHunter, Deborah M Hodgson, Deborah M Hodgson, Deborah M Hodgson, Deborah M Hodgson   +29 more
doaj   +1 more source

Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia

Nature Neuroscience, 2016
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral prefrontal cortex of people with schizophrenia (N = 258) and control subjects (
M. Fromer, P. Roussos, S. Sieberts, Jessica S. Johnson, D. Kavanagh, T. Perumal, D. Ruderfer, Edwin C. T. Oh, A. Topol, H. Shah, L. Klei, R. Kramer, D. Pinto, Z. Gümüş, A. E. Cicek, Kristen K. Dang, A. Browne, Cong Lu, Lu Xie, B. Readhead, E. Stahl, Jianqiu Xiao, Mahsa Parvisi, T. Hamamsy, J. Fullard, Ying-Chih Wang, M. Mahajan, J. Derry, J. Dudley, S. Hemby, Benjamin A. Logsdon, K. Talbot, T. Raj, T. Raj, D. Bennett, P. D. Jager, P. D. Jager, Jun Zhu, Bin Zhang, Patrick F. Sullivan, Patrick F. Sullivan, A. Chess, S. Purcell, L. Shinobu, L. Mangravite, Hiroyoshi Toyoshiba, R. Gur, C. Hahn, D. Lewis, V. Haroutunian, M. Peters, B. Lipska, J. Buxbaum, E. Schadt, K. Hirai, K. Roeder, K. Brennand, N. Katsanis, E. Domenici, B. Devlin, P. Sklar   +60 more
semanticscholar   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

BDNF and the maturation of posttranscriptional regulatory networks in human SH-SY5Y neuroblast differentiation

Frontiers in Cellular Neuroscience, 2014
The SH-SY5Y culture system is a convenient neuronal model with the potential to elaborate human/primate-specific transcription networks and pathways related to human cognitive disorders.
Belinda J Goldie, Belinda J Goldie, Michelle M Barnett, Murray J Cairns, Murray J Cairns   +4 more
doaj   +1 more source

The effect of training intensity on implicit learning rates in schizophrenia

Scientific Reports, 2021
Cognitive impairments in learning and memory are core symptoms of schizophrenia, associated with reduced self-reported quality of life. The most effective treatment of cognitive impairments is drill and practice cognitive training.
Natasza D. Orlov, Jessica Sanderson, Syed Ali Muqtadir, Anastasia K. Kalpakidou, Panayiota G. Michalopoulou, Jie Lu, Sukhi S. Shergill   +6 more
doaj   +1 more source