Results 81 to 90 of about 620,945 (334)

Genetic identification of brain cell types underlying schizophrenia

Nature Genetics, 2017
With few exceptions, the marked advances in knowledge about the genetic basis of schizophrenia have not converged on findings that can be confidently used for precise experimental modeling. By applying knowledge of the cellular taxonomy of the brain from
N. Skene, J. Bryois, Trygve E Bakken, G. Breen, J. Crowley, Héléna A. Gaspar, P. Giusti-Rodríguez, R. Hodge, Jeremy A. Miller, A. B. Muñoz-Manchado, M. O’Donovan, M. Owen, A. Pardiñas, J. Ryge, J. Walters, S. Linnarsson, E. Lein, P. Sullivan, J. Hjerling-Leffler   +18 more
semanticscholar   +1 more source

The Impact of the Parental Patterns of Morbidity and Comorbidity in the Cross‐Generational Transmission of Risk for Major Depression and Alcohol Use Disorder

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT To further understand the inter‐relationship of the familial transmission of major depression (MD) and alcohol use disorder (AUD), we examine, via a multivariable Cox proportional hazards model, risks for AUD and MD in 1,244,516 individuals born in Sweden from 1970 to 1990 to intact mother–father pairs as a function of parental diagnoses of MD
Kenneth S. Kendler, Linda Abrahamsson, Jan Sundquist, Kristina Sundquist   +3 more
wiley   +1 more source

Appraisal of Gene Expression‐Based Classifiers for Neuropsychiatric Disorders: A Meta‐Regression

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT A substantial body of research examines the potential of gene‐expression‐based biomarkers for diagnosing and selecting treatments for neuropsychiatric disorders, yet no clear consensus has been reached regarding the influence of controllable factors such as study design and model selection on the performance of gene‐expression‐based ...
Ali Razavi, Brittany Arensman, Eric J. Barnett, Leo A. Lee, Stephen V. Faraone, Stephen J. Glatt, Jonathan L. Hess   +6 more
wiley   +1 more source

Schizophrenia [PDF]

BMJ, 2007
Picchioni, M M, Murray, R M
openaire   +4 more sources

Supporting the Recovery of NDIS Participants With Psychosocial Disability: A Narrative Literature Review

Australian Journal of Social Issues, EarlyView.
ABSTRACT This narrative literature review examines key issues surrounding psychosocial disability support in the National Disability Insurance Scheme (NDIS). It highlights the NDIS's neoliberal approach to support, which has underpinned a lack of clarity around the conceptualisation of psychosocial disability and recovery.
Johnny Choi, Kathy Ellem, John Drayton
wiley   +1 more source

Rare coding variants in ten genes confer substantial risk for schizophrenia

Nature, 2022
T. Singh, T. Poterba, D. Curtis, H. Akil, M. A. Al Eissa, J. Barchas, N. Bass, T. Bigdeli, G. Breen, E. Bromet, Peter F. Buckley, W. Bunney, J. Bybjerg-Grauholm, W. Byerley, S. Chapman, Wei J. Chen, C. Churchhouse, N. Craddock, C. Cusick, L. DeLisi, S. Dodge, M. Escamilla, S. Eskelinen, A. Fanous, S. Faraone, A. Fiorentino, L. Francioli, S. Gabriel, D. Gage, S. G. Gagliano Taliun, A. Ganna, G. Genovese, D. Glahn, J. Grove, M. Hall, E. Hämäläinen, H. Heyne, M. Holi, D. Hougaard, D. Howrigan, Hailiang Huang, H. Hwu, R. Kahn, H. Kang, K. Karczewski, G. Kirov, J. Knowles, F. Lee, D. Lehrer, F. Lescai, D. Malaspina, S. Marder, S. Mccarroll, A. McIntosh, H. Medeiros, L. Milani, C. Morley, D. Morris, P. Mortensen, R. Myers, M. Nordentoft, N. O’Brien, A. M. Olivares, D. Ongur, W. Ouwehand, D. Palmer, T. Paunio, D. Quested, M. Rapaport, E. Rees, B. Rollins, F. Satterstrom, A. Schatzberg, E. Scolnick, L. Scott, Sally Sharp, P. Sklar, J. Smoller, J. Sobell, M. Solomonson, E. Stahl, C. Stevens, J. Suvisaari, G. Tiao, S. Watson, N. Watts, D. Blackwood, A. Børglum, B. Cohen, A. Corvin, T. Esko, N. Freimer, S. Glatt, C. Hultman, A. McQuillin, A. Palotie, C. Pato, M. Pato, A. Pulver, D. St. Clair, M. Tsuang, M. Vawter, J. Walters, T. Werge, R. Ophoff, Patrick F. Sullivan, M. Owen, M. Boehnke, M. O’Donovan, B. Neale, M. Daly   +110 more
semanticscholar   +1 more source

Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group

Molecular Psychiatry, 2017
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies.
S. Kelly, N. Jahanshad, A. Zalesky, P. Kochunov, I. Agartz, C. Alloza, O. Andreassen, C. Arango, N. Banaj, S. Bouix, C. Bousman, R. Brouwer, J. Bruggemann, J. Bustillo, W. Cahn, V. Calhoun, D. Cannon, V. Carr, S. Catts, J. Chen, J.X. Chen, X. Chen, C. Chiapponi, K. K. Cho, V. Ciullo, A. Corvin, B. Crespo-Facorro, V. Cropley, P. de Rossi, C. Díaz-Caneja, E. Dickie, S. Ehrlich, F. Fan, Joshua Faskowitz, H. Fatouros-Bergman, L. Flyckt, J. Ford, J. Fouche, M. Fukunaga, M. Gill, D. Glahn, R. Gollub, E. Goudzwaard, H. Guo, R. Gur, R. Gur, T. Gurholt, R. Hashimoto, S. Hatton, F. Henskens, D. Hibar, I. Hickie, L. Hong, J. Horáček, F. Howells, H. H. Hulshoff Pol, C. Hyde, D. Isaev, A. Jablensky, P. Jansen, J. Janssen, E. Jönsson, L. Jung, R. Kahn, Z. Kikinis, K. Liu, P. Klauser, C. Knöchel, M. Kubicki, J. Lagopoulos, C. Langen, S. Lawrie, R. Lenroot, K. Lim, C. López-Jaramillo, A. Lyall, V. Magnotta, R. Mandl, D. Mathalon, R. McCarley, S. McCarthy-Jones, C. Mcdonald, S. McEwen, A. McIntosh, T. Melicher, R. Mesholam-Gately, P. Michie, B. Mowry, B. Mueller, D. Newell, P. O’Donnell, V. Oertel-Knöchel, L. Oestreich, S. Paciga, C. Pantelis, O. Pasternak, G. Pearlson, G. Pellicanò, A. Pereira, J. P. Pineda Zapata, F. Piras, S. Potkin, Adrian Preda, P. Rasser, D. Roalf, R. Roiz, A. Roos, D. Rotenberg, T. Satterthwaite, P. Savadjiev, U. Schall, R. Scott, M. Seal, L. Seidman, C. Shannon Weickert, C. Whelan, M. Shenton, J. Kwon, G. Spalletta, F. Španiel, E. Sprooten, M. Stäblein, Dan J Stein, S. Sundram, Y. Tan, S. Tan, S. Tang, H. Temmingh, L. Westlye, S. Tønnesen, D. Tordesillas-Gutiérrez, N. T. Doan, J. Vaidya, N. V. van Haren, C. Vargas, D. Vecchio, D. Velakoulis, A. Voineskos, J. Voyvodic, Z. Wang, P. Wan, D. Wei, T. Weickert, H. Whalley, T. White, T. Whitford, J. Wojcik, H. Xiang, Z. Xie, H. Yamamori, F. Yang, N. Yao, G. Zhang, J. Zhao, T. V. van Erp, J. Turner, P. Thompson, G. Donohoe   +157 more
semanticscholar   +1 more source

A potential strategy for improving offspring behavior in maternal immune activation: Amantadine‐mediated suppression of neuroinflammation

Animal Models and Experimental Medicine, EarlyView.
Amantadine (AMA) regulates neurocyte apoptosis and inhibits neurocyte inflammation to prevent maternal immune activation (MIA) from affecting offspring behavior. Abstract Background Maternal viral infection during pregnancy can lead to maternal immune activation (MIA), increasing the risk of neurodevelopmental disorders in offspring.
Jianfei Wu, Yu Liu, Binglong Wang, Yilin Wang, Bo Liu, Youguo Tan, Duanfang Cai, Kezhi Liu, Daixu Wei   +8 more
wiley   +1 more source

Poor self-reported sleep is associated with prolonged white matter T2 relaxation in psychotic disorders

Frontiers in Psychiatry
BackgroundPsychotic disorders are characterized by white matter (WM) abnormalities; however, their relationship with the various aspects of illness presentation remains unclear.
Umit Haluk Yesilkaya, Umit Haluk Yesilkaya, Xi Chen, Xi Chen, Lauren Watford, Emma McCoy, Meltem Sen, Ilgin Genc, Fei Du, Fei Du, Dost Ongur, Dost Ongur, Cagri Yuksel, Cagri Yuksel   +13 more
doaj   +1 more source

What does a mouse tell us about neuregulin 1 – cannabis interactions?

Frontiers in Cellular Neuroscience, 2013
The link between cannabis and psychosis has been debated although there is substantial epidemiological evidence showing that cannabis increases the risk of psychosis.
Tim eKarl, Tim eKarl, Tim eKarl, Jonathon Carl Arnold, Jonathon Carl Arnold, Jonathon Carl Arnold   +5 more
doaj   +1 more source