Results 21 to 30 of about 69 (69)

Novel TORC1 inhibitor Ecl1 is regulated by phosphorylation in fission yeast

Aging Cell, Volume 24, Issue 4, April 2025.
Extender of chronological lifespan 1 (Ecl1), which inhibits the target of rapamycin complex 1 (TORC1), physically interacts with TORC1 subunits and is necessary for appropriate cellular responses to various stressors, such as starvation, in fission yeast. Several functions of Ecl1 are suppressed by Thr7 phosphorylation when nutrients are abundant.
Hokuto Ohtsuka, Sawa Kawai, Yurika Ito, Yuka Kato, Takafumi Shimasaki, Kazuki Imada, Yoko Otsubo, Akira Yamashita, Emi Mishiro‐Sato, Keiko Kuwata, Hirofumi Aiba   +10 more
wiley   +1 more source

A steric gate prevents mutagenic dATP incorporation opposite 8‐oxo‐deoxyguanosine in mitochondrial DNA polymerases

The FEBS Journal, EarlyView.
Reactive oxygen species induce mutagenic DNA lesions, such as 8‐oxo‐2′‐deoxyguanosine (8‐oxodG), which acts as a template for dCMP and dAMP incorporation through its anti and syn conformations. Specific residues must regulate the fidelity of templated 8‐oxodG.
Noe Baruch‐Torres, Carlos H. Trasviña‐Arenas, Alexandru Ionut Gilea, Upeksha C. Dissanayake, Missael Molina‐Jiménez, Paola L. García‐Medel, Corina Díaz‐Quezada, Tiziana Lodi, G. Andrés Cisneros, Enrico Baruffini, Luis G. Brieba   +10 more
wiley   +1 more source

Saccharomyces cerevisiae Mub1, a substrate adaptor of E3 ubiquitin ligase Ubr2, modulates sensitivity to cell wall stressors through multiple transcription factors

The FEBS Journal, EarlyView.
We show that Mub1 links cell wall robustness with the ubiquitin‐proteasome system. As an adaptor protein of the E3 ubiquitin ligase Ubr2, it facilitates the ubiquitination of various transcription factors, including Mcm1 and Swi4. Yeasts evolved a complex regulatory programme to build and maintain their cell wall, the primary structure through which ...
Nada Šupljika, Antonia Paić, Ana Novačić, Tea Martinić Cezar, Béatrice Vallée, Renata Teparić, Igor Stuparević, Bojan Žunar   +7 more
wiley   +1 more source

Dynamics of interphase microtubules in Schizosaccharomyces pombe [PDF]

Current Biology, 2000
Microtubules in interphase Schizosaccharomyces pombe are essential for maintaining the linear growth habit of these cells. The dynamics of assembly and disassembly of these microtubules are so far uncharacterised.Live cell confocal imaging of alpha1 tubulin tagged with enhanced green fluorescent protein revealed longitudinally oriented, dynamically ...
Robert A. Cross, Douglas Robert Drummond
openaire   +3 more sources

Transcription‐coupled repair: tangled up in convoluted repair

The FEBS Journal, EarlyView.
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher, Yun Jin Pai, Alex Pines, Wim Vermeulen   +3 more
wiley   +1 more source

The genomic and phenotypic diversity of Schizosaccharomyces pombe [PDF]

Nature Genetics, 2015
Natural variation within species reveals aspects of genome evolution and function. The fission yeast Schizosaccharomyces pombe is an important model for eukaryotic biology, but researchers typically use one standard laboratory strain. To extend the usefulness of this model, we surveyed the genomic and phenotypic variation in 161 natural isolates.
Daniel C Jeffares, Charalampos Rallis, Adrien Rieux, Doug Speed, Martin Převorovský, Tobias Mourier, Francesc X Marsellach, Zamin Iqbal, Winston Lau, Tammy M K Cheng, Rodrigo Pracana, Michael Mülleder, Jonathan L D Lawson, Anatole Chessel, Sendu Bala, Garrett Hellenthal, Brendan O'Fallon, Thomas Keane, Jared T Simpson, Leanne Bischof, Bartlomiej Tomiczek, Danny A Bitton, Theodora Sideri, Sandra Codlin, Josephine E E U Hellberg, Laurent van Trigt, Linda Jeffery, Juan-Juan Li, Sophie Atkinson, Malte Thodberg, Melanie Febrer, Kirsten McLay, Nizar Drou, William Brown, Jacqueline Hayles, Rafael E Carazo Salas, Markus Ralser, Nikolas Maniatis, David J Balding, Francois Balloux, Richard Durbin, Jürg Bähler   +41 more
openaire   +5 more sources

Whole‐Genome Sequencing and Phenotyping Reveal Specific Adaptations of Lachancea thermotolerans to the Winemaking Environment

Molecular Ecology, EarlyView.
ABSTRACT Adaptation to the environment plays an essential role in yeast evolution as a consequence of selective pressures. Lachancea thermotolerans, a yeast related to fermentation and one of the current trends in wine technology research, has undergone an anthropisation process, leading to a notable genomic and phenomic differentiation.
Javier Vicente, Anne Friedrich, Joseph Schacherer, Kelle Freel, Domingo Marquina, Antonio Santos   +5 more
wiley   +1 more source

Methionine as an antimutagen in Schizosaccharomyces pombe [PDF]

Journal of General Microbiology, 1965
Methionine inhibition of the phenotypic expression of adn - → adn + reverse mutations in the fission yeast Schizosaccharomyces pombe was investigated. This inhibition occurred solely with L-methionine, and not with a variety of other growth factors. The inhibitory effect on revertant expression did not apply to a number of reverse and forward mutations
openaire   +2 more sources

ESSENTIAL MEIOTIC ENDONUCLEASE 1 is required for chloroplast development and DNA repair in rice

Plant Biotechnology Journal, EarlyView.
Summary Chloroplast development is fundamental to photosynthesis and plant growth but is sensitive to environmental stress. Chloroplast development and division require genome stability and DNA repair, but the underlying mechanisms have been unclear. Using a forward genetic approach, we identified the striped‐leaf mutant k48 in the rice (Oryza sativa L.
Yanxin Du, Yang Li, Weijiang Tang, Weiping Mo, Tingting Ma, Rongcheng Lin   +5 more
wiley   +1 more source

Non‐coding RNAs in plant stress responses: molecular insights and agricultural applications

Plant Biotechnology Journal, EarlyView.
Summary Non‐coding RNAs (ncRNAs) have emerged as crucial regulators in plant responses to environmental stress, orchestrating complex networks that finetune gene expression under both abiotic and biotic challenges. To elucidate this intricate ncRNA crosstalk, this review comprehensively summarizes recent advances in understanding the mechanisms of key ...
Xiaotong Chen, Zhaohui Chen, Ryan Watts, Hong Luo   +3 more
wiley   +1 more source