Results 91 to 100 of about 74,140 (300)

A steric gate prevents mutagenic dATP incorporation opposite 8‐oxo‐deoxyguanosine in mitochondrial DNA polymerases

The FEBS Journal, EarlyView.
Reactive oxygen species induce mutagenic DNA lesions, such as 8‐oxo‐2′‐deoxyguanosine (8‐oxodG), which acts as a template for dCMP and dAMP incorporation through its anti and syn conformations. Specific residues must regulate the fidelity of templated 8‐oxodG.
Noe Baruch‐Torres, Carlos H. Trasviña‐Arenas, Alexandru Ionut Gilea, Upeksha C. Dissanayake, Missael Molina‐Jiménez, Paola L. García‐Medel, Corina Díaz‐Quezada, Tiziana Lodi, G. Andrés Cisneros, Enrico Baruffini, Luis G. Brieba   +10 more
wiley   +1 more source

Distinct requirements for the Rad32(Mre¹¹) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA [PDF]

, 2009
For a cancer cell to resist treatment with drugs that trap topoisomerases covalently on the DNA, the topoisomerase must be removed. In this study, we provide evidence that the Schizosaccharomyces pombe Rad32Mre11 nuclease activity is involved in the ...
Akamatsu, Antony M. Carr, Baldwin, Champoux, Connelly, Connelly, Edgar Hartsuiker, El-Khamisy, Farah, Gutz, Hartsuiker, Hopfner, Hopfner, Keeney, Keeney, Krogh, Krogh, Lengsfeld, Limbo, Liu, Malik, Matthew J. Neale, McKee, Miyoshi, Moreau, Neale, Nitiss, Osheroff, Porter, Pouliot, Prinz, Sartori, Shaw, Stracker, Subramanian, Takashima, Tomita, Utsugi, Young   +38 more
core   +2 more sources

Saccharomyces cerevisiae Mub1, a substrate adaptor of E3 ubiquitin ligase Ubr2, modulates sensitivity to cell wall stressors through multiple transcription factors

The FEBS Journal, EarlyView.
We show that Mub1 links cell wall robustness with the ubiquitin‐proteasome system. As an adaptor protein of the E3 ubiquitin ligase Ubr2, it facilitates the ubiquitination of various transcription factors, including Mcm1 and Swi4. Yeasts evolved a complex regulatory programme to build and maintain their cell wall, the primary structure through which ...
Nada Šupljika, Antonia Paić, Ana Novačić, Tea Martinić Cezar, Béatrice Vallée, Renata Teparić, Igor Stuparević, Bojan Žunar   +7 more
wiley   +1 more source

Population genomics of the fission yeast Schizosaccharomyces pombe. [PDF]

PLoS ONE, 2014
The fission yeast Schizosaccharomyces pombe has been widely used as a model eukaryote to study a diverse range of biological processes. However, population genetic studies of this species have been limited to date, and we know very little about the ...
Jeffrey A Fawcett, Tetsushi Iida, Shohei Takuno, Ryuichi P Sugino, Tomoyuki Kado, Kazuto Kugou, Sachiko Mura, Takehiko Kobayashi, Kunihiro Ohta, Jun-ichi Nakayama, Hideki Innan   +10 more
doaj   +1 more source

Involvement of Schizosaccharomyces pombe rrp1+ and rrp2+ in the Srs2- and Swi5/Sfr1-dependent pathway in response to DNA damage and replication inhibition [PDF]

, 2013
Previously we identified Rrp1 and Rrp2 as two proteins required for the Sfr1/Swi5-dependent branch of homologous recombination (HR) in Schizosaccharomyces pombe.
Ahn, Akamatsu, Akamatsu, Akamatsu, Antony M. Carr, Cal-Bąkowska, Caspari, Craven, Doe, Doe, Dorota Dziadkowiec, Dupaigne, Dziadkowiec, Feng, Gareau, Haruta, Hecker, Hope, Hope, Ira, Jensen, Jia, Karol Kramarz, Karolina Kanik, Khasanov, Krogh, Kurokawa, Lambert, Lambert, Liu, Liu, Liu, Lorenz, Mankouri, McGlynn, Miyabe, Moreno, Morishita, Mullen, Mullen, Murray, New, Osman, Osterman, Piotr Wiśniewski, Prakash, Prudden, Raji, Rijkers, Say, Sebesta, Shinohara, Shinohara, Stewart, Sun, Sun, Sun, Sung, Symington, Thacker, Tsubouchi, Tsutsui, Uzunova, Win, Yuan   +64 more
core   +1 more source

Aging and cell death in the other yeasts, Schizosaccharomyces pombe and Candida albicans.

FEMS Yeast Research, 2014
How do cells age and die? For the past 20 years, the budding yeast, Saccharomyces cerevisiae, has been used as a model organism to uncover the genes that regulate lifespan and cell death.
Su-Ju Lin, N. Austriaco
semanticscholar   +1 more source

Transcription‐coupled repair: tangled up in convoluted repair

The FEBS Journal, EarlyView.
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher, Yun Jin Pai, Alex Pines, Wim Vermeulen   +3 more
wiley   +1 more source

Whole‐Genome Sequencing and Phenotyping Reveal Specific Adaptations of Lachancea thermotolerans to the Winemaking Environment

Molecular Ecology, EarlyView.
ABSTRACT Adaptation to the environment plays an essential role in yeast evolution as a consequence of selective pressures. Lachancea thermotolerans, a yeast related to fermentation and one of the current trends in wine technology research, has undergone an anthropisation process, leading to a notable genomic and phenomic differentiation.
Javier Vicente, Anne Friedrich, Joseph Schacherer, Kelle Freel, Domingo Marquina, Antonio Santos   +5 more
wiley   +1 more source

Force and length-dependent catastrophe activities explain interphase microtubule organization in fission yeast [PDF]

, 2008
The cytoskeleton is essential for the maintenance of cell morphology in eukaryotes. In fission yeast for example, polarized growth sites are organized by actin whereas microtubules (MT) acting upstream control where growth occurs (La Carbona et al, 2006).
arxiv   +1 more source

Cdk1 restrains NHEJ through phosphorylation of XRCC4-like factor Xlf1 [PDF]

, 2014
Eukaryotic cells use two principal mechanisms for repairing DNA double-strand breaks (DSBs): homologous recombination (HR) and nonhomologous end-joining (NHEJ). DSB repair pathway choice is strongly regulated during the cell cycle.
Almeida, Aylon, Cavero, Chiruvella, Clerici, Dischinger, Ferreira, Ferretti, Frank-Vaillant, Hentges, Huertas, Ira, Kegel, Kinoshita, Limbo, Manolis, Matsuzaki, Moreno, Symington, Valencia, Walworth, Zhang   +21 more
core   +2 more sources