Results 111 to 120 of about 45,803 (270)

150 Class I and II neoantigen mapping in MSI-high colorectal cancer in needle biopsy size tissue samples

Journal for ImmunoTherapy of Cancer, 2023
Roland Bruderer, Marco Tognetti, Lukas Reiter, Ilja E Shapiro, Luca Raess, Tikira Temu, Oliver M Bernhardt, Yuehan Feng, Jonathan Woodsmith   +8 more
doaj   +1 more source

Review of the Application of Schlieren Systems in the Field of Hydrogen and Hydrogen Blends

Energies
Against the backdrop of the global transition toward clean and low-carbon energy systems, hydrogen has emerged as a promising alternative to fossil fuels owing to its carbon-free characteristics and broad cross-sector applicability.
Xinmeng Zhang, Zilong Zhang, Jiangtao Sun, Yujie Ouyang, Jing Zhang, Bin Li, Lifeng Xie   +6 more
doaj   +1 more source

Intrathecal administration of Anti-Nogo-A antibody in macaque monkeys: Pharmacokinetics, tissue penetration and target interaction

Neurotherapeutics
Intrathecal drug administration represents a promising method to deliver biologics effectively to the central nervous system (CNS). However, little is known about the tolerability and pharmacokinetics of intrathecally applied antibodies. Hence, the focus
Pascal B. Kunz, Michael A. Maurer, Jannik Vollmer, Matthias Machacek, Oliver Weinmann, Jelena Klisic, Martin E. Schwab   +6 more
doaj   +1 more source

721 Ongoing phase 1 study of MP0317, a FAP-CD40 DARPin, shows a favorable safety profile and early evidence of tumor-localized CD40 activation in patients with advanced solid tumors

Journal for ImmunoTherapy of Cancer, 2023
Anne Goubier, Neeltje Steeghs, Carlos Gomez-Roca, Philippe Cassier, Elena Fernandez, Eelke Gort, Hilde De Winter, Vaia Stavropoulou, Nina Stojcheva, Paul Baverel, Jennifer Krieg, Kyriaki Ioannou, Ana Maria Florescu, Lea Hoenig, Bruno Baud-Berthier, Michael P Sanderson, Vladimir Kirkin, Philippe Legenne   +17 more
doaj   +1 more source

Endothelial JCAD Worsens Acute Ischemic Stroke Outcomes by Enhancing Inflammation in Response to Ischemia/Reperfusion

JACC: Basic to Translational Science
Summary: The role of junctional protein associated with coronary artery disease (JCAD) in acute ischemic stroke (AIS) has not been investigated yet. To investigate its potential as a therapeutic target, transient middle cerebral artery occlusion was ...
Stefano Ministrini, MD, PhD, Yustina M. Puspitasari, MD, PhD, Georgia Beer, MSc, Lena Schwarz, MSc, Rebecca Niederberger, MSc, Simon Kraler, MD, PhD, Florian A. Wenzl, MD, Mira Katan, MD, PhD, Marco Bacigaluppi, MD, PhD, Aurora Semerano, MD, Alexander Akhmedov, PhD, Susan Bengs, PhD, Fabrizio Montecucco, MD, PhD, Thomas F. Lüscher, MD, PhD, Giovanni G. Camici, PhD, Luca Liberale, MD, PhD   +15 more
doaj   +1 more source

P329G-engager: a universal mix & match antibody-based adaptor platform for cancer immunotherapy

mAbs
Targeting various combinations of tumor antigens and immune cell receptors is of increasing importance in antibody-based cancer immunotherapy. Here, we present a novel modular P329G-engager platform that enables rapid combination of primary tumor ...
Marlena Surowka, Diana Darowski, Idil Hutter-Karakoc, Christina Claus, Claudia Ferrara-Koller, Anne Freimoser-Grundschober, Thomas Hofer, Johannes Sam, Reto Gianotti, Andrzej Sobieniecki, Denis Assisi, John Challier, Stephane Leclair, Ekkehard Mössner, Maria Amann, Pablo Umaña, Christian Klein   +16 more
doaj   +1 more source

CARD8: A Novel Inflammasome Sensor with Well-Known Anti-Inflammatory and Anti-Apoptotic Activity

Cells
Inflammasomes comprise a group of protein complexes with fundamental roles in the induction of inflammation. Upon sensing stress factors, their assembly induces the activation and release of the pro-inflammatory cytokines interleukin (IL)-1β and -18 and ...
Tugay Karakaya, Marta Slaufova, Michela Di Filippo, Paulina Hennig, Thomas Kündig, Hans-Dietmar Beer   +5 more
doaj   +1 more source

Clostridium perfringens Periprosthetic Joint Infection: Case Report and Literature Review

Annals of Internal Medicine: Clinical Cases
Periprosthetic joint infection (PJI) remains a devastating complication after arthroplasty and very rarely PJI are due to anaerobes that usually lead to delayed and late infections.
Roman Dähler, Daniel Baunach, Roberto Buonomano   +2 more
doaj   +1 more source

Hazardous Gas Leak Analysis in the Space Shuttle [PDF]

, 1991
Helium tests of the main propulsion system in the Space Shuttle and on hydrogen leaks are examined. The hazardous gas detection system (HGDS) in the mobile launch pad uses mass spectrometers (MS) to monitor the shuttle environment for leaks.
Barile, Ronald G.
core   +1 more source

Estradiol Downregulates MicroRNA-193a to Mediate Its Angiogenic Actions

Cells
Estrogens regulate many physiological processes in the human body, including the cardiovascular system. Importantly, Estradiol (E2) exerts its vascular protective actions, in part, by promoting endothelial repair via induction of endothelial cell (EC ...
Lisa Rigassi, Mirel Adrian Popa, Ruth Stiller, Brigitte Leeners, Marinella Rosselli, Raghvendra Krishna Dubey   +5 more
doaj   +1 more source