Results 111 to 120 of about 19,796 (265)

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

AJPC academy: A four-pillar model for cultivating the next generation of academic leaders in cardiovascular prevention. [PDF]

Am J Prev Cardiol
Vergara Sanchez C, Dudum R, Shapiro MD, Nasir K.   +3 more
europepmc   +1 more source

Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

Advanced Science, EarlyView.
PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li, Yanan Liu, Meng Zhang, Yiwei Liu, Meiting Liu, Kaishen Zhu, Zhian Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Commentary: Editorial bullying: an exploration of acts impacting publication ethics and related environment. [PDF]

Front Res Metr Anal
Shirani A.
europepmc   +1 more source

Systematic Metabolic Engineering and Model‐Guided Optimization for High‐Level Production of L‐Theanine from Xylose in Escherichia coli

Advanced Science, EarlyView.
This study is pioneering in constructing the shortest known synthetic pathway for L‐theanine production from xylose within E coli. Through comprehensive metabolic engineering strategies, our engineered strain achieved the highest reported L‐theanine titer from xylose, with a titer of 95.42 g/L, and a yield of 0.55 g/g.
Haolin Han, Boyuan Xue, Guangqi Shan, Meng Meng, Shaojie Wang, Haijia Su   +5 more
wiley   +1 more source

A bibliometric analysis of research on the learning environment in medical schools: trends, gaps, and global perspectives. [PDF]

Front Med (Lausanne)
Alblooshi AS, Almarzooqi FM, Punn A, Almansoori TM, Alharthi RS, Alzaabi SA, Ahmed G, Al-Shamsi S, AlRadini FA.   +8 more
europepmc   +1 more source

Lattice Genome Framework for Regionally Tailored Component‐Level Multi‐Objective Design in Additive Manufacturing

Advanced Science, EarlyView.
A Lattice Genome framework links geometric and process “genes” to lattice “phenotypes” via correction‐calibrated high‐throughput simulations and a growing performance database. Genome‐driven retrieval and recombination of unit cells enables component‐level, regionally tailored multi‐objective design: stress fields are programmed under constant relative
Haoyuan Deng, Yufan Zhao, Mingyang Cao, Haiou Yang, Pan Wang, Hongze Wang, Hao Wang, Akihiko Chiba, Xin Lin   +8 more
wiley   +1 more source

Altmetrics in the evaluation of scholarly impact: a systematic and critical literature review. [PDF]

Front Res Metr Anal
González P, Fors M, Torres A.
europepmc   +1 more source

KMT2C Loss Promotes NF2‐Wildtype Meningioma Progression and Ferroptosis Sensitivity via Epigenetic Repression of Hippo Signaling

Advanced Science, EarlyView.
In NF2–wild‐type meningiomas, loss of the epigenetic regulator KMT2C suppresses NF2 transcription and inactivates Hippo signaling, driving tumor progression and increasing ferroptosis sensitivity. Restoration of histone acetylation reverses these effects and inhibits tumor growth, identifying KMT2C as a key regulator linking epigenetic control, NF2 ...
Liuchao Zhang, Yangfan Ye, Wei Gu, Xinyue Wang, Nuo Chen, Qixin He, Lei Xu, Pengzhan Zhao, Guoqiang Fu, Guangyao Yuan, Wenqian Shi, Honglu Chao, Yiming Tu, Jing Ji   +13 more
wiley   +1 more source

Editorial: Advances in the neurobiology and neuropsychology of offending behaviour. [PDF]

Front Psychiatry
Khalifa NR, Völlm BA.
europepmc   +1 more source