Results 71 to 80 of about 31,402,141 (256)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Implementing and Evaluating Empirically Based Family and School Programmes for Children with Conduct Problems in Norway [PDF]

, 2009
This paper discusses the implementation and evaluation of two family and school based intervention programmes for children and young people in Norway, namely Parent Management Training (PMTO, Ogden & Amlund Hagen, in press) and PALS (Sorlie & Ogden, 2007)
Ogden, Terje, Marie-Anne Sorlie, Terje Ogden, Sorlie, Anne-Mari   +3 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Three year school based intervention for Tobacco prevention in the region of Sousse: quasi experimental design 2009-2014

, 2018
Background Tobacco use is one of the biggest public health threats the world has ever faced. Tunisia is one of the countries suffering from the heavy burden of tobacco use.
Sana Bhiri, Jihen Maatoug, Rim Ghammam, Ferdaous Ouni, Hassen Ghannem, Jihen Sahli   +5 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The impact of a school-based water supply and treatment, hygiene, and sanitation programme on pupil diarrhoea: a cluster-randomized trial. [PDF]

, 2013
The impact of improved water, sanitation, and hygiene (WASH) access on mitigating illness is well documented, although impact of school-based WASH on school-aged children has not been rigorously explored. We conducted a cluster-randomized trial in Nyanza
Brumback, B, DREIBELBIS, R., Muga, R, RHEINGANS, R., CLASEN, T., Dreibelbis, R, Rheingans, R, MUGA, R., Saboori, S, Greene, LE, SABOORI, S., Freeman, MC, GREENE, L. E., FREEMAN, M. C., BRUMBACK, B., Clasen, T   +15 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Virtual learning intervention to reduce bullying victimization in Primary School: a controlled trial [PDF]

, 2010
Background: Anti-bullying interventions to date have shown limited success in reducing victimization and have rarely been evaluated using a controlled trial design.
Dieter Wolke, Wolfgang Schneider, Dautenhahn, K., Watson, Scott, Natalie Vannini, Aylett, Ruth, Vannini, Natalie, Sibylle Enz, Maria Sapouna, Woods, Sarah, Paiva, Ana, Ruth Aylett, Schneider, Wolfgang, Enz, Sibylle, Andre, Elizabeth, Dautenhahn, Kerstin, Lynne Hall, Kerstin Dautenhahn, Hall, Lynne, Wolke, Dieter, Sapouna, Maria, Sarah Woods, Elizabeth Andre, Ana Paiva, André, Elisabeth, Scott Watson   +25 more
core   +1 more source

A formative evaluation of the Silence The Violence programme : a school-based violence prevention programme [PDF]

, 2010
Includes summary.Includes bibliographical references (leaves 63-68).This report presents the findings of a formative evaluation of the Silence The Violence (STV) programme, a school-based violence prevention initiative. The programme is implemented by an
Phillips, Lynn
core   +1 more source