Results 81 to 90 of about 1,097,446 (312)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Cosmic rays studied with a hybrid high school detector array [PDF]
, 2007 The LORUN/NAHSA system is a pathfinder for hybrid cosmic ray research combined with education and outreach in the field of astro-particle physics. Particle detectors and radio antennae were mainly setup by students and placed on public buildings.
de Vos, C. M. +9 more
core +3 more sources
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Natural ventilation systems to enhance sustainability in buildings: a review towards zero energy buildings in schools [PDF]
, 2017 European regulations set the condition of Zero Energy Buildings for new buildings since 2020, with an intermediate milestone in 2018 for public buildings, in order to control greenhouse gases emissions control and climate change mitigation.
Barrios Padura, Ángela +3 more
core +2 more sources
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Les espaces scolaires en France
Revue Internationale d’Éducation de Sèvres, 2013 This article reports on a round table concerning school spaces in France, which brought together a principal, an education authority director, a representative of a large region and an architect.
Maurice Mazalto +5 more
doaj +1 more source
An anomaly detection method for identifying locations with abnormal behavior of temperature in school buildings. [PDF]
Sci Rep, 2023 Wickramasinghe A +3 more
europepmc +1 more source
Teaching the Dynamic Earth: Earth Science Out of Doors [PDF]
These activities are designed to show how Earth science principles can be illustrated out of doors, often without a rock in sight, and how pupils can be engaged in discussions about Earth processes and products. In the 'neighborhood stone watch' students
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source