Results 51 to 60 of about 1,813,642 (313)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Active Shooter Events: The Guardian Plan

open access: yesSchool Leadership Review, 2018
The decision on how to protect the children and youth while at schools is a serious conversation with varying agreements on the best practices. Some feel that school personnel should not be trained nor expected to be able to react to an armed person ...
David R. Walker, Pauline M. Sampson
doaj  

Impact Philanthropy to Improve Teaching Quality: Focus on High-Need Secondary Students [PDF]

open access: yes, 2011
Offers models for improving teachers' skills, including through apprenticeships and in-school mentoring; for creating an environment for great teaching through better leadership and whole-school reform; and guidance for donors on the policy ...
Katherina Rosqueta   +3 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

A Comparison of Principal Self-Efficacy and Assessment Ratings by Certified Staff: Using Multi-Rater Feedback as Part of a Statewide Principal Evaluation System

open access: yesSchool Leadership Review, 2013
A vast body of research supports the notion that school leadership is the second most influential factor on student achievement, behind only the classroom teacher (Davis & Darling-Hammond, 2012; Lynch, 2012; Mendels & Mitgang, 2013; Miller, 2013; Pannell,
Summer Pannell, Lisa White
doaj  

Securing a College Prep Curriculum for All Students [PDF]

open access: yes, 2009
Presents a case study of community organizing for school reform by Los Angeles' Community Coalition: how its intergenerational campaign for college preparatory classes shaped leadership development, district policy, school capacity, and student ...
Kavitha Mediratta   +2 more
core  

The role of whole-school contexts in shaping the experiences and outcomes associated with professional development [PDF]

open access: yes, 2007
Review of the article 'The role of whole-school contexts in shaping the experiences and outcomes associated with professional development'. The study examined the in-service programme in relation to different school contexts (size, type, disadvantaged ...
Harris, Linda
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Accountability and Students' Needs

open access: yesSchool Leadership Review, 2014
Our schools are working under many pressures often with increased expectations and less resources. These increased expectations hold administrators and teachers to high accountability standards while working with increased diverse populations of students.
Pauline M. Sampson, Kerry L. Roberts
doaj  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

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