Results 111 to 120 of about 3,339,817 (343)

Engineering and Structural Elucidation of a Sac7d‐Derived IgG Fc‐Specific Affitin and Its Application for the Light‐Controlled Affinity Purification of Antibodies

open access: yesChemBioChem, EarlyView.
An affitin derived from the Sac7d scaffold enables the light‐controlled affinity purification of antibodies under physiological conditions, thus overcoming limitations of protein A chromatography. X‐ray crystallographic analysis and affinity measurements reveal complex formation with Fc at the CH2/CH3 junction, similar to protein A/G and FnRn. Combined
Felix Veitl   +7 more
wiley   +1 more source

Design and Evaluation of Bivalent K‐Ras Inhibitors That Target the CAAX Binding Site and the Acidic Surface of Farnesyltransferase and Geranylgeranyltransferase I

open access: yesChemistry – A European Journal, EarlyView.
Chemical inhibition of K‐Ras posttranslational prenylation represents a promising strategy against aggressive cancers. A structure‐based design produces piperidine‐based peptidomimetics conjugated to cationic modules, effectively inhibiting FTase and GGTase I at single‐digit nanomolar concentrations.
Naomi Horiuchi   +8 more
wiley   +1 more source

Differential Equations Compatible with KZ Equations [PDF]

open access: yesarXiv, 2000
We define a system of "dynamical" differential equations compatible with the KZ differential equations. The KZ differential equations are associated to a complex simple Lie algebra $\mathbf{g}$. These are equations on a function of $n$ complex variables $z_i$ taking values in the tensor product of $n$ finite dimensional $\mathbf{g}$-modules.
arxiv  

Positive solutions of the nonlinear Schrödinger equation with the fractional Laplacian

open access: yesProceedings of the Royal Society of Edinburgh: Section A Mathematics, 2012
We study the existence of positive solutions for the nonlinear Schrödinger equation with the fractional Laplacian \begin{gather*}(-\Delta)^{\alpha}u+u=f(x,u)\text{~in~}\mathbb{R}^{N},\\u>0\text{~in~}\mathbb{R}^{N},\qquad\lim_{|x|\rightarrow\infty}u(x)=0.\
P. Felmer, A. Quaas, Jinggang Tan
semanticscholar   +1 more source

Organocatalytic switches of DNA glycosylase OGG1 catalyze a highly efficient AP‐lyase function

open access: yesChemistry – A European Journal, Accepted Article.
8‐oxoGuanine DNA glycosylase 1 (OGG1) is the first known target of organocatalytic switches (ORCAs), which rewrite the biochemical function of the enzyme through redirection of its preferred substrate from 8‐oxoG to AP sites. Previously, different ORCA chemotypes were shown to enhance the operational pH window for OGG1, possibly through direct ...
Mario Kehler   +28 more
wiley   +1 more source

New Solution Method of Time-dependent Schrödinger Equation Using Improved Boundary Conditions

open access: yesActive and Passive Electronic Components, 2001
Numerical solution of the time-dependent Schrödinger equation for open system structures has been impeded by the difficulty in handing open-system boundary conditions. This paper presents a new numerical method for time-dependent Schrödinger equation and
C. P. Song, M. R. Lee, K. F. Yarn
doaj   +1 more source

Direct integral method, complete discrimination system for polynomial and applications to classifications of all single traveling wave solutions to nonlinear differential equations:a survey [PDF]

open access: yesarXiv, 2006
Complete discrimination system for polynomial and direct integral method were discussed systematically. In particularly, we pointed out some mistaken viewpoints. Combining with complete discrimination system for polynomial, direct integral method was developed to become a powerful method and was applied to a lot of nonlinear mathematical physics ...
arxiv  

Structure‐Binding Relationship of 2‐Amino‐1,8‐Naphthyridine Dimers: Role of Linkage Positions on DNA and RNA Recognition

open access: yesChemistry – A European Journal, EarlyView.
Altering the connecting positions of two 2‐amino‐1,8‐naphthyridine units modulates binding to distinct DNA and RNA motifs. This structural variation influences molecular interactions, affecting stacking tendencies and hydrogen bonding. The positional differences determine how these molecules recognize cytosine‐rich sequences, impacting their ability to
Bimolendu Das   +5 more
wiley   +1 more source

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