Results 221 to 230 of about 112,215 (282)

Modifying inhibitor specificity for homologous enzymes by machine learning

The FEBS Journal, EarlyView.
We present a machine learning method for the design of selective enzyme inhibitors, reducing experimental effort thus accelerating the development of targeted therapeutics. Trained on existing data for three related matrix metalloproteinases (MMPs), our method successfully designed a novel inhibitor variant with enhanced selectivity for one MMP over ...
Dor S. Gozlan, Reut Meiri, Gili Shapira, Matt Coban, Evette S. Radisky, Yaron Orenstein, Niv Papo   +6 more
wiley   +1 more source

Retraction notice to "Soliton dynamics in optical fiber based on nonlinear Schrödinger equation" [Heliyon 9 (2023) e14235]. [PDF]

Heliyon
Abdillah Mardi H, Nasaruddin N, Ikhwan M, Nurmaulidar N, Ramli M.   +4 more
europepmc   +1 more source

Soliton dynamics in optical fiber based on nonlinear Schrödinger equation.

Heliyon, 2023
Abdillah Mardi H, Nasaruddin N, Ikhwan M, Nurmaulidar N, Ramli M.   +4 more
europepmc   +1 more source

Collapse for the higher-order nonlinear Schrödinger equation

, 2015
Vassos Achilleos, S. Diamantidis, D. J. Frantzeskakis, Theodoros P. Horikis, Nikos I. Karachalios, P. G. Kevrekidis   +5 more
openalex   +2 more sources

Structural investigation of human U6 snRNA recognition by spliceosomal recycling factor SART3 RNA recognition motifs

The FEBS Journal, EarlyView.
Human SART3 has two RRM domains to engage with U6 snRNA for spliceosome recycling. This study reports solution structures of SART3 RRM domains and investigates the interaction between RRM and U6 snRNA. SART3 binds to the asymmetric bulge of U6 snRNA as a dimer via conserved positively charged surfaces.
Iktae Kim, Kyeong‐Mi Bang, So Young An, Changkon Park, Ji‐Yeon Shin, Youngim Kim, Hyun Kyu Song, Jeong‐Yong Suh, Nak‐Kyoon Kim   +8 more
wiley   +1 more source

Investigation of soliton solutions to the (2 + 1)-dimensional stochastic chiral nonlinear Schrödinger equation with bifurcation, sensitivity and chaotic analysis. [PDF]

Sci Rep
Alqhtani M, Shahbaz A, Abbas M, Saad KM, Birhanu A, Yousaf MZ.   +5 more
europepmc   +1 more source

Instability of solitary waves for a generalized derivative nonlinear Schrödinger equation in a borderline case [PDF]

, 2016
Noriyoshi Fukaya
openalex   +1 more source

The importin‐alpha superfamily engages in ethylene signaling by shuttling ETHYLENE INSENSITIVE 2 from the endoplasmic reticulum to the nucleus

The FEBS Journal, EarlyView.
The plant hormone ethylene regulates plant growth, ripening, senescence, and stress responses. The hormonal signal transmission, from receptors at the ER membrane to the transcriptional regulators in the nucleus, is still not completely understood.
Fabian Wynen, Jan Eric Maika, Raphael Josef Eberle, Nina Jahnke, Marcel Wiermer, Laura Hartmann, Rüdiger Simon, Georg Groth   +7 more
wiley   +1 more source

Reliable numerical scheme for coupled nonlinear Schrödinger equation under the influence of the multiplicative time noise. [PDF]

Sci Rep
Baber MZ, Ahmed N, Yasin MW, Iqbal MS, Akgül A, Hassani MK, Jawaz M.   +6 more
europepmc   +1 more source

Structural and functional characterization of the newly identified Photorhabdus laumondii tumor necrosis factor‐like lectin

The FEBS Journal, EarlyView.
We characterize the PLTL lectin from Photorhabdus laumondii, which adopts a unique TNF‐like fold. Binding assays reveal a preference for branched histo‐blood group oligosaccharides. Protein crystallography uncovers a novel hexameric assembly and identifies key residues involved in carbohydrate recognition.
Filip Melicher, Pavel Dobeš, Jan Komárek, Lukáš Faltinek, Marek Korsák, Petra Sýkorová, Josef Houser, Michaela Wimmerová   +7 more
wiley   +1 more source