Results 91 to 100 of about 3,015 (151)

Thiazolidinedione–Pyrazolopyrimidinone Molecular Hybrids With Alkyl Spacers: Potential Antitubercular Agents Complemented by Molecular Modeling

open access: yesChemistrySelect, Volume 11, Issue 24, 25 June 2026.
We report the synthesis of 21 novel thiazolidinedione–pyrazolopyrimidinone derivatives (12a–u), prepared by coupling thiazolidinedione and pyrazolopyrimidinone pharmacophores through various alkyl linkers. The compounds were characterized spectroscopically and evaluated against the Mtb H37Rv strain, identifying compounds 5c and 5d as potent ...
Pule Seboletswe   +8 more
wiley   +1 more source

Prospects of Quantum Computing

open access: yesSmartSys, Volume 2, Issue 2, June 2026.
ABSTRACT It has been anticipated that quantum computing (QC) would solve computational tasks involving quantum phenomena intractable for supercomputers based on digital technology. Concurrently, however, the vast development of artificial intelligence (AI) has resulted in systems targeting these real‐world problems with unprecedented progress including
Shili Zhang   +3 more
wiley   +1 more source

Peptide binding at the gasdermin D exosite reveals the structural basis for targeting the site

open access: yesActa Crystallographica Section D, Volume 82, Issue 6, Page 615-625, June 2026.
We describe the first structure of gasdermin D with a putative caspase inhibitor peptide analog at 1.6 Å resolution. This work suggests potential druggability of gasdermin D at the exosite by leveraging structure‐based computational design with biochemical characterization.Gasdermin D (GSDMD) has been identified as a critical component of the ...
Renjing Wang   +15 more
wiley   +1 more source

Aging, Dauer, and Stature Phenotypes Are Conferred by Structure‐Directed Missense Mutations in the Endogenous AGE‐1/Phosphatidylinositol 3‐Kinase Catalytic Subunit

open access: yesAging Cell, Volume 25, Issue 6, June 2026.
Structure‐guided missense mutations in the C. elegans AGE‐1/PI3Kinase catalytic subunit and its LET‐60/Ras‐binding interface reveal separable signaling outputs from the Ras‐bound PI3K complex. Enhanced canonical catalytic activity, conferred by a gain‐of‐function mutation modeled on oncogenic human p110⍺ PI3K variants, promotes aging, reproductive ...
You Wu   +4 more
wiley   +1 more source

The structure of intact and active Photosystem II from Arabidopsis thaliana at 2.44 Å resolution

open access: yesNew Phytologist, Volume 250, Issue 5, Page 3014-3025, June 2026.
Summary Photosystem II (PS II) is a large membrane‐bound protein complex that catalyses light‐driven water oxidation in plants and cyanobacteria. The structure of PS II is well studied in cyanobacteria; however, there are very few PS II structures from plants.
Jack Forsman   +6 more
wiley   +1 more source

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