Results 61 to 70 of about 3,015 (151)

Synthesis and Evaluation of Aromatic Sulfonamide and Disulfonamide Derivatives as Dengue Virus NS3–NS5 Interaction Inhibitors

open access: yesChemMedChem, Volume 21, Issue 11, 15 June 2026.
A synthetic methodology for the preparation of asymmetric benzene‐1,4‐disulfonamides was developed and applied to generate potential anti‐dengue virus (DENV) compounds. Guided by computer‐assisted structural rationalization, we designed synthetically more accessible analogs with reduced toxicity that interact with the DENV NS5 domain, thereby ...
Jakub Janáč   +8 more
wiley   +1 more source

Seniority‐Zero Quadratic Canonical Transformation Theory

open access: yesInternational Journal of Quantum Chemistry, Volume 126, Issue 12, June 15, 2026.
We construct a unitary transformation of electronic Hamiltonians using quadratic canonical transformation theory, choosing the transformation to minimize the non‐seniority‐zero elements of the transformed Hamiltonian. This allows us to add dynamic correlation to the static correlation inherent in orbital‐optimized doubly‐occupied (seniority‐zero ...
Daniel F. Calero‐Osorio, Paul W. Ayers
wiley   +1 more source

High‐Energy Topological Edge States and Strain‐Induced Multiple Flat Bands in a Honeycomb Lattice

open access: yesNanophotonics, Volume 15, Issue 11, 13 June 2026.
This work proposes a novel anti‐twig edge in the honeycomb lattice that supports two symmetric high‐energy edge states. Moreover, the suppression or enhancement of the high‐energy edge state is observed, and strain‐induced multiple flat bands are produced.
Xiaoqin Bai   +4 more
wiley   +1 more source

Enantioselective Synthesis of Lactic Acid From CO2 Using a Novel Pyruvate Decarboxylase in a Scalable Biocatalytic Cascade

open access: yesAdvanced Synthesis &Catalysis, Volume 368, Issue 11, 3 June 2026.
We report a scalable biocatalytic cascade that converts CO2 and acetaldehyde to pyruvate via a newly characterized pyruvate decarboxylase, followed by stereoselective reduction to lactic acid. The system enables fully switchable enantioselectivity using either L‐ or D‐lactate dehydrogenases.
Silvia Fruncillo   +9 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, Volume 600, Issue 11, Page 1621-1637, June 2026.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Evolution and Conceptual Insights into the Geometric Phase of Light: A Comprehensive Review

open access: yesAdvanced Photonics Research, Volume 7, Issue 6, June 2026.
This review presents a unified account of the geometric phase of light, linking its fundamental principles to diverse manifestations in polarization, spatial, and vector modes. By connecting theoretical frameworks with key experimental realizations, it reveals a coherent physical picture that deepens understanding and stimulates new directions in ...
A. Srinivasa Rao
wiley   +1 more source

Decoding Aquaculture's Future: A Review of Molecular Docking and Simulation in Enhancing Growth and Disease Resistance

open access: yesAquaculture, Fish and Fisheries, Volume 6, Issue 3, June 2026.
ABSTRACT Aquaculture has overtaken capture fisheries as the main source of aquatic animal protein, marking a critical step in global food security. Yet, rapid intensification faces major challenges, including disease outbreaks, environmental degradation, and dependence on wild‐caught fish for feed.
Suvadip Ghara   +8 more
wiley   +1 more source

Wave Mechanics of Ciliary Proteins: Quantum‐Enabled Sensing and Energy Transfer in the “Cellular Antenna”

open access: yesAggregate, Volume 7, Issue 6, June 2026.
This review surveys eukaryotic cilia as putative quantum‐enabled sensory and regulatory centers. It highlights their multifaceted roles in the cell, focuses on the nontrivial roles of quantum mechanics in their membrane and cytoskeletal proteins, and introduces the essential building blocks enabling quantum properties to survive in the warm, wet, and ...
Daniel L. Bilezikian   +5 more
wiley   +1 more source

On the Meaning of Localization in Non‐Local Quantum Field Theory

open access: yesAnnalen der Physik, Volume 538, Issue 6, June 2026.
In non‐local quantum field theory nature does not necessarily allow objects or events to be localized to exact mathematical points. Instead any physical measurement has a built‐in finite resolution set by the non‐locality scale. Spacetime remains continuous and Lorentz‐covariant, but below this scale pointlike localization becomes an idealization ...
E. J. Thompson
wiley   +1 more source

Enhanced Electron Reflection at Mott‐Insulator Interfaces

open access: yesAnnalen der Physik, Volume 538, Issue 6, June 2026.
A condensed‐matter analog of the Klein paradox is demonstrated at a Mott‐insulator‐semiconductor interface. Using the hierarchy of correlations, Schrödinger‐like equations for doublons and holons as well as boundary conditions are derived. For incident energies below mid‐gap, the interface exhibits anomalous reflection probabilities exceeding unity ...
Jan Verlage, Peter Kratzer
wiley   +1 more source

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