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Current Opinion in Cell Biology, 1996
Recent studies of Schwann cell differentiation in vivo and in vitro have provided new insights into determinative signal transduction events both at the cell surface and in the nucleus. Several polypeptide growth factors and their receptors, most notably the neuregulins and receptors of the ErbB family, have been implicated in the specification of cell
Greg Lemke +2 more
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Recent studies of Schwann cell differentiation in vivo and in vitro have provided new insights into determinative signal transduction events both at the cell surface and in the nucleus. Several polypeptide growth factors and their receptors, most notably the neuregulins and receptors of the ErbB family, have been implicated in the specification of cell
Greg Lemke +2 more
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1982
Although Schwann cells were not a topic in the previous series of this Handbook, their properties were covered in a general review of the peripheral nerve by Porcellati.1 In addition, aspects of protein and lipid metabolism in peripheral nerve undergoing Wallerian degeneration were reviewed.2,3 Interest in the peripheral nervous system has grown over ...
Robert M. Gould +2 more
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Although Schwann cells were not a topic in the previous series of this Handbook, their properties were covered in a general review of the peripheral nerve by Porcellati.1 In addition, aspects of protein and lipid metabolism in peripheral nerve undergoing Wallerian degeneration were reviewed.2,3 Interest in the peripheral nervous system has grown over ...
Robert M. Gould +2 more
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Cold Spring Harbor Protocols, 2014
This article introduces methods for the acute purification and primary culture of Schwann cells from the mouse sciatic nerve. Immunopanning can be used to isolate Schwann cells from intact nerves during early postnatal development as well as to purify Schwann cells from adult nerves following sciatic nerve injury.
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This article introduces methods for the acute purification and primary culture of Schwann cells from the mouse sciatic nerve. Immunopanning can be used to isolate Schwann cells from intact nerves during early postnatal development as well as to purify Schwann cells from adult nerves following sciatic nerve injury.
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2013
The fundamental roles of Schwann cells during peripheral nerve formation and regeneration have been recognized for more than 100 years, but the cellular and molecular mechanisms that integrate Schwann cell and axonal functions continue to be elucidated.
Bruce D. Trapp +2 more
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The fundamental roles of Schwann cells during peripheral nerve formation and regeneration have been recognized for more than 100 years, but the cellular and molecular mechanisms that integrate Schwann cell and axonal functions continue to be elucidated.
Bruce D. Trapp +2 more
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Intermediate Filaments of Schwann Cells
Journal of Neurochemistry, 1982Abstract: Intermediate filaments were prepared from distal stumps of rabbit sciatic nerve 5 weeks after nerve section, at which time Schwann cells account for 85–90% of the cell area. A polypeptide of molecular weight 58,000 was the main component of this fraction. An antiserum raised in guinea pig against this polypeptide stained all cells present in
Jack Sipple +3 more
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Rhythmic Contraction of Schwann Cells [PDF]
Science, 1959 By time-lapse cinematography it was found that Schwann cells in tissue cultures of dorsal root ganglia from newborn rats show a contraction rate of approximately 4 to 18 minutes. This activity is of the order of magnitude reported for oligodendroglia.
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Mechanism of phagocytosis by Schwann cells
Journal of the Neurological Sciences, 198633B rat Schwannoma cell line is known to exhibit phagocytic properties analogous to those of normal Schwann cells. The mechanism of phagocytosis by this cell line was investigated by studying the effect of known modulators of phagocytosis on the uptake of latex particles by these cells. Treatments which block energy production of the host cell, such as
Alok Bhattacharya +2 more
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Immunomodulation by Schwann cells in disease
Cancer Immunology, Immunotherapy, 2019Schwann cells are the principal glial cells of the peripheral nervous system which maintain neuronal homeostasis. Schwann cells support peripheral nerve functions and play a critical role in many pathological processes including injury-induced nerve repair, neurodegenerative diseases, infections, neuropathic pain and cancer.
Sophia H. Zhang +6 more
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Schwann Cells in Phylogeny [PDF]
, 2003 Schwann cells are the nonneuronal cells that ensheath peripheral axons. Brought to prominence by Theodor Schwann in 1839 these cells have, until recently, been considered to be relatively passive components of the nerve, apart from their vital role in providing myelin sheaths around the larger axons.
Helen Stewart, Kristjan R. Jessen
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Schwann cell energy to die for
Nature Neuroscience, 2020A new study shows that, immediately after axon injury, glycolysis is increased in Schwann cells to provide axons with energy and prevent them from degenerating. The authors also identify possible therapeutic targets that could be modulated to promote axonal protection.
Amelia Trimarco, Carla Taveggia
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