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Schwann Cell Dysfunction in Acromegaly
The Journal of Clinical Endocrinology & Metabolism, 1970ABSTRACT The pathologic features observed in a sural nerve biopsy from a subject with acromegalic peripheral neuropathy are presented. Examination of individually teased nerve fibers revealed diffuse segmental demyelination. Since each internodal segment represents the territory occupied by a single Schwann cell, the presence of the segmental loss of ...
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Epigenetic Control of Schwann Cells
The Neuroscientist, 2018The journey of Schwann cells from their origin in the neural crest to their ensheathment and myelination of peripheral nerves is a remarkable one. Their apparent static function in enabling saltatory conduction of mature nerve is not only vital for long-term health of peripheral nerve but also belies an innate capacity of terminally differentiated ...
Ki H. Ma, John Svaren
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Schwann cells transplanted into the CNS
International Journal of Developmental Neuroscience, 1993AbstractA small volume of purified Schwann cells, cultured from early postnatal rat sciatic nerve, was injected into the hippocampus or fimbria of syngeneic adult hosts. The procedure caused minimal structural disturbance at the transplantation site, with close graft‐host contact and maximal opportunity for integration.The donor Schwann cells were ...
J.M. Lawrence +2 more
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Astrocytoma and Schwann cells in coculture
Molecular and Chemical Neuropathology, 1996Glial fibrillary acidic protein (GFAP) is the principal intermediate filament protein found in mature astrocytes. Although the exact function of GFAP is poorly understood, it is presumed to stabilize the astrocyte's cytoskeleton and help in maintaining cell shape. Previous studies from our laboratory have shown that when astrocytes were cocultured with
Lawrence F. Eng +3 more
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The Schwann cell at the neuromuscular junction
Journal of Physiology-Paris, 1998Synapses obtained in vitro in a system of co-culture of muscle cells and neurons are of embryonic type. We prepared a monoclonal antibody (6.17) which recognizes a molecule synthesized by Schwann cells and used it to show that the main characteristics of maturity (decrease in number of synapses, appearance of junctional folds, and suppression of ...
Jacqueline Chapron +3 more
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Imaging of Schwann Cells In Vivo
2011The ability to examine cells tagged with fluorescent proteins in vivo has led to exciting advances in molecular neurobiology. The integral role of Schwann cells in nerve regeneration is well characterized, but not until recently has dynamic imaging of these critical cells been possible.
Rahul Kasukurthi, Terence M. Myckatyn
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Isolation and Culture of Schwann Cells
2013Primarily cultured Schwann cells are essential for the investigation of molecular mechanisms regulating proliferation, survival, differentiation, and myelination of Schwann cell and for the development of efficient transplantation for regeneration of injured spinal cord or peripheral nervous system.
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The biology and pathobiology of Schwann cells
Current Opinion in Neurology, 1997The most common forms of inherited demyelinating neuropathy in humans are caused by mutations in the genes encoding protein zero, peripheral myelin protein 22 kDa, and connexin32, all of which are expressed by myelinating Schwann cells and are components of the myelin sheath. The phenotype of myelinating Schwann cells depends on the maintenance of axon-
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Axon-Schwann Cell Relationship
1984Publisher Summary The fast-conducting unmyelinated fibers of the squid offer exceptional opportunities for the study of the relationships between the axon and its satellite Schwann cells. The large size of the axon dictates a special axon–glia relationship, which consists in a multiplicity of Schwann cells necessary to cover up the perimeter of the ...
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