Results 61 to 70 of about 257,634 (292)

Thomas Manns Stil [PDF]

open access: yes, 2011
Thomas Mann (1875-1955) war ein deutscher Schriftsteller, der unter der nationalsozialistischen Herrschaft 1933 in die Schweiz emigrierte und 1939 in die USA zog. 1944 wurde er amerikanischer Staatsbürger, kehrte aber 1952 in die Schweiz zurück. Er zählt
Куницкая, Оксана Сергеевна
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Gleichheit durch individuelle Lösungen? Betriebliche Folgen des Wirtschaftsnutzendiskurses in der aktuellen schweizerischen Gleichstellungspolitik

open access: yesGender, 2014
Der Beitrag beleuchtet Mechanismen, die geschlechtsspezifische (Un-)Gleichheit in Unternehmen fördern. Dabei interessiert das Zusammenspiel von innerbetrieblichen Vorstellungen und dem dominierenden Diskurs der aktuellen schweizerischen ...
Lucia Marina Lanfranconi
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

International Public Procurement Agreements - Problems of Implemetations in Switzerland [PDF]

open access: yes
Öffentliche Beschaffung, Reform, Public Choice, Wohlfahrtstheorie, Schweiz, Public Procurement, Welfare economics ...
Christoph Kilchenmann   +2 more
core  

Anspruch auf Änderung des Arbeitspensums : Anregungen zur Stärkung der Zeitsouveränität von Arbeitnehmenden [PDF]

open access: yes, 2018
Arbeitnehmende in privatrechtlichen Arbeitsverhältnissen riskieren in der Schweiz den Verlust ihrer Stelle, wenn sie ihr Arbeitspensum reduzieren wollen. Für Arbeitskräfte in Deutschland und den Niederlanden besteht hingegen ein gesetzlicher Anspruch auf
Steiger-Sackmann, Sabine
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Work after the Age of Fifty: Switzerland in an international Comparison [PDF]

open access: yes
Ältere Arbeitskräfte, Arbeitsmarkt, Arbeitsmarktpolitik, Schweiz, Elderly workforce, Labour market, Labour market policy ...
Anne Sonnet, Giovanni Ferro Luzzi
core  

Perinatal mental disorders in Switzerland : prevalence estimates and use of mental-health services [PDF]

open access: yes, 2017
Background: Perinatal mental disorders (PMDs) are the most common complication of pregnancy and the first postpartum year. Since PMD prevalence and use of mental-health services by perinatal women in Switzerland are unknown, we analysed existing health ...
Bachmann, Nicole   +6 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy