Results 71 to 80 of about 89,270 (291)

Urgeschichte der Schweiz im Überblick (15000 v.Chr. –Christi Geburt). Die Konstruktion einer Urgeschichte

, 2016
Nach einer langen methodischen Einleitung wird die Entwicklung der regionalen (kulturellen) Gliederung der Schweiz und die Entwicklung der Gesellschaftsstruktur ...
Stöckli, Werner Ernst
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Schweiz. Unfallversicherungs A.G. in Winterthur

SCHWEIZ. UNFALLVERSICHERUNGS A.G. IN WINTERTHUR Schweiz. Unfallversicherungs A.G. in Winterthur ( -
Schweiz. Unfallversicherungs A.G.
core   +2 more sources

Presenteeism and team culture: a qualitative study of health care and office professionals / Präsentismus und Teamkultur: eine qualitative Befragung von Gesundheit- und Bürofachpersonen

International Journal of Health Professions
Presenteeism – working even though you are ill – is a widespread phenomenon that has negative consequences for both employees and employers. It particularly affects healthcare professionals (HCPs) and, due to working from home, increasingly also office ...
Klopfenstein Flurina Anna, Golz Christoph, Blättler Ramona Linda, Eissler Christian, Peter Karin Anne   +4 more
doaj   +1 more source

Problématique des agglomérations suisses [PDF]

Geographica Helvetica
Dieser Artikel gibt einen Überblick über die wichtigsten Fragen, die sich heute in der Agglomeration der Schweiz stellen. Er analysiert die städtische Entwicklungspolitik, die Verkehrspolitik, die Verkehrsplanung sowie die Sozialfrage.
J. Wolff
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Flow-augmentation STA-MCA bypass for acute and subacute ischemic stroke due to internal carotid artery occlusion: the role of advanced neuroimaging in the decision-making

Brain and Spine, 2023
Martina Sebök, Lara Höbner, Jorn Fierstra, Tilman Schubert, Susanne Wegener, Zsolt Kulcsar, Andreas Luft, Luca Regli, Giuseppe Esposito   +8 more
doaj   +1 more source