Results 71 to 80 of about 280,960 (341)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Vineyard Leaf Canopy Management: Timing of the First Hedge-Trimming
IVES Technical ReviewsDelaying the date of the first hedge-trimming (or ‘tip-pruning’) is of limited technical value in vineyard canopy management. The impact of the delay on lateral shoot growth and must composition remains marginal within the context of the La Côte ...
Thibaut Verdenal +4 more
doaj +1 more source
History Studies, 2023 Das neunzehnte Jahrhundert ist für europäische Wissenschaftler/innen ein Jahrhundert der Forschungsreisen. Sie bezogen sich auf unbekannte Länder außerhalb Europas und generell Zentralasien, speziell Osttürkistan waren ein wichtiger Teil dieser ...
Çiğdem Dumanlı
doaj
International Public Procurement Agreements - Problems of Implemetations in Switzerland [PDF]
Öffentliche Beschaffung, Reform, Public Choice, Wohlfahrtstheorie, Schweiz, Public Procurement, Welfare economics ...
Christoph Kilchenmann +2 more
core
Buchbesprechung: Weber, E. (2009): Pflanzenleben der Schweiz. Swiss Plant Life [PDF]
, 2013 Das Buch ist in 14 Kapitel gegliedert, von denen die ersten sechs schwerpunktmäßig einen geographisch- ökologischen Überblick über die Schweiz und allgemein-botanische Informationen (Kap. 3) geben. Hierzu gehören 1. Die Landschaften der Schweiz, 2. Flora
Krumbiegel, Anselm
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Weather patterns and hydro-climatological precursors of extreme floods in Switzerland since 1868
Meteorologische Zeitschrift, 2012 The generation of 24 extreme floods in large catchments of the central Alps is analyzed from instrumental and documentary data, newly digitized observations of precipitation (DigiHom) and 20th Century Reanalysis (20CR) data. Extreme floods are determined
Peter Stucki +6 more
doaj +1 more source
Work after the Age of Fifty: Switzerland in an international Comparison [PDF]
Ältere Arbeitskräfte, Arbeitsmarkt, Arbeitsmarktpolitik, Schweiz, Elderly workforce, Labour market, Labour market policy ...
Anne Sonnet, Giovanni Ferro Luzzi
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Gender, 2014 Der Beitrag beleuchtet Mechanismen, die geschlechtsspezifische (Un-)Gleichheit in Unternehmen fördern. Dabei interessiert das Zusammenspiel von innerbetrieblichen Vorstellungen und dem dominierenden Diskurs der aktuellen schweizerischen ...
Lucia Marina Lanfranconi
doaj +1 more source