Results 41 to 50 of about 65,822 (289)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Epithelioid sarcoma involving sciatic nerve with lung metastasis and local recurrence: A case report

Interdisciplinary Neurosurgery, 2019
Involvement of a deep peripheral nerve by epithelioid sarcoma (ES) is extremely rare, especially in sciatic nerve. It is a highly aggressive malignant tumor with poor prognosis and comparatively difficult to detect and confirm diagnosis in early stage ...
Maimaiaili Yushan, PhD, Alimujiang Abulaiti, MD, Yamuhanmode Alike, PhD, Peng Ren, MD, Aihemaitijiang Yusufu, PhD   +4 more
doaj   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Clinical importance of anatomical variants of sciatic nerve in relation to the piriformis muscle

National Journal of Clinical Anatomy, 2012
Background and aims: The sciatic nerve usually emerges below the Piriformis muscle. Each anatomical variant of sciatic nerve is associated with a specific clinical presentation.
Rashmi Deopujari, Dibya Kishore Satpathi, Ashutosh S Mangalgiri   +2 more
doaj   +1 more source

Endoscopic Sciatic Neurolysis for Deep Gluteal Space Syndrome

Video Journal of Sports Medicine, 2022
Background: Deep gluteal syndrome (DGS) encompasses a spectrum of pathologies causing symptomatic sciatic nerve compression deep to the gluteus maximus muscle.
Nicholas A. Trasolini MD, Morgan Rice BS, Katlynn Paul BS, Shane J. Nho MD, MS   +3 more
doaj   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

Cadaveric Study on Variations in the Level of Bifurcation of Sciatic Nerve and its Clinical Implications [PDF]

International Journal of Anatomy Radiology and Surgery, 2019
Introduction: Sciatic nerve is the thickest nerve of the human body arising from the sacral plexus. It bifurcates into tibial nerve and common fibular nerve at any level from the pelvis to the popliteal fossa. Variations in the level of bifurcation of
Mayankkumar D Javia, Sanjay K Vikani
doaj   +1 more source

Sciatic Nerve Intrafascicular Injection Induces Neuropathy by Activating the Matrix Modulators MMP-9 and TIMP-1

Frontiers in Pharmacology, 2022
Background: Peripheral nerve block (PNB) under echo guidance may not prevent intrafascicular anesthetic injection-induced nerve injury. This study investigated whether unintended needle piercing alone, or the intrafascicular nerve injectant could induce ...
Kuang-Yi Tseng, Kuang-Yi Tseng, Hung-Chen Wang, Kai-Feng Cheng, Yi-Hsuan Wang, Lin-Li Chang, Lin-Li Chang, Lin-Li Chang, Lin-Li Chang, Kuang-I Cheng, Kuang-I Cheng   +10 more
doaj   +1 more source

Avaliação das repercussões do exercício físico sobre a regeneração nervosa de ratos Wistar submetidos a axonotmese do nervo isquiático [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas, Florianópolis, 2014.Lesões do sistema nervoso periférico são comuns e acarretam perdas tanto
Guedert, Denis Guilherme
core  

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source