Results 41 to 50 of about 107,483 (323)

A Rabbit Model for Peripheral Nerve Reconstruction Studies Avoiding Automutilation Behavior

Journal of Brachial Plexus and Peripheral Nerve Injury, 2022
Background The rabbit sciatic nerve injury model may represent a valuable alternative for critical gap distance seen in humans but often leads to automutilation. In this study, we modified the complete sciatic nerve injury model for avoiding autophagy.
Jonathan A. Sorkin, Ziv Rechany, Mara Almog, Nina Dietzmeyer, Yuval Shapira, Kirsten Haastert-Talini, Shimon Rochkind   +6 more
doaj   +1 more source

Clinical importance of anatomical variants of sciatic nerve in relation to the piriformis muscle

National Journal of Clinical Anatomy, 2012
Background and aims: The sciatic nerve usually emerges below the Piriformis muscle. Each anatomical variant of sciatic nerve is associated with a specific clinical presentation.
Rashmi Deopujari, Dibya Kishore Satpathi, Ashutosh S Mangalgiri   +2 more
doaj   +1 more source

Sciatic Nerve Intrafascicular Injection Induces Neuropathy by Activating the Matrix Modulators MMP-9 and TIMP-1

Frontiers in Pharmacology, 2022
Background: Peripheral nerve block (PNB) under echo guidance may not prevent intrafascicular anesthetic injection-induced nerve injury. This study investigated whether unintended needle piercing alone, or the intrafascicular nerve injectant could induce ...
Kuang-Yi Tseng, Kuang-Yi Tseng, Hung-Chen Wang, Kai-Feng Cheng, Yi-Hsuan Wang, Lin-Li Chang, Lin-Li Chang, Lin-Li Chang, Lin-Li Chang, Kuang-I Cheng, Kuang-I Cheng   +10 more
doaj   +1 more source

Postoperative pain and morphine consumption after ultrasound-guided femoral and sciatic combined nerve block versus neurostimulation for femoral and sciatic combined nerve block or neurostimulation for femoral nerve block in primary elective total knee arthroplasty. [PDF]

, 2017
Congreso XXXVII National Meeting of the Spanish Society of Pharmacology with guest society: The British Pharmacological SocietyBackground and Aims: Total knee arthroplasty injuries are extremely painful and merit prompt attention to adequate ...
Bellido-Estevez, Inmaculada, Blanco-Reina, Encarnacion, Gomez-Luque, Jose Aurelio, Perez-Millón, V   +3 more
core  

Morphology and Nanomechanics of Sensory Neurons Growth Cones following Peripheral Nerve Injury [PDF]

, 2012
A prior peripheral nerve injury in vivo, promotes a rapid elongated mode of sensory neurons neurite regrowth in vitro. This in vitro model of conditioned axotomy allows analysis of the cellular and molecular mechanisms leading to an improved neurite re ...
A Nilsson, A Vinckier, AB Huber, AB Mathur, AL Weisenhorn, AR Bausch, Attila-Gergely Végh, B Geiger, C Hilaire, ChC Dupont-Gillain, Csilla Gergely, DM Suter, DS Smith, E Evans, E Spedden, EW Dent, F Charron, Frédérique Scamps, H-J Butt, HA McNally, HA McNally, HJ Song, HS Xiao, I Mechaly, Igor Sokolov, IN Sneddon, J Dai, J Laishram, J Sleep, JL Goldberg, K Tanaka, KD Costa, L Lankford K, M Mustata, M Radmacher, M Radmacher, Marta Martin, MG Hertz, MJ Rosenbluth, Olivier Lucas, Ouafa Benzina, OV Chumakova, PN Hoffman, R García, R Lal, S Andre, S Pieraut, S Pieraut, SS Hannila, T Araki, T Tojima, TC Dickson, Thierry Cloitre, TS Lanero, V Heinrich, Vivien Szabo, Y Xiong, ZL Chen   +57 more
core   +5 more sources

The Role of Ionic Liquids at the Biological Interfaces in Bioelectronics

Advanced Science, EarlyView.
Ionic liquids (ILs) are highlighted as key artificial ionic materials that bridge biological ion‐based signaling and electronic devices. By understanding their composition, structure, function relationships, and mechanisms, ILs can advance from high performance electrolyte to core materials enabling integrated, multifunctional bioelectronics for ...
Yeong‐sinn Ye, Young Jin Jo, Ji Yeon Oh, Ju Yeon Jeong, Lili Guo, Tae‐il Kim   +5 more
wiley   +1 more source

Sciatic Nerve Palsy following Curved Periacetabular Osteotomy

Case Reports in Orthopedics, 2020
Curved periacetabular osteotomy (CPO) is used for the treatment of dysplastic hips. Previous studies have reported satisfying outcomes and low rate of severe complications associated with this procedure; however, no case of postoperative sciatic nerve ...
Masahiro Fujita, Shinya Hayashi, Kenichi Kikuchi, Yoshinori Takashima, Tomoyuki Kamenaga, Masanori Tsubosaka, Koji Fukuda, Koji Takayama, Shingo Hashimoto, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto   +11 more
doaj   +1 more source

Cadaveric Study on Variations in the Level of Bifurcation of Sciatic Nerve and its Clinical Implications [PDF]

International Journal of Anatomy Radiology and Surgery, 2019
Introduction: Sciatic nerve is the thickest nerve of the human body arising from the sacral plexus. It bifurcates into tibial nerve and common fibular nerve at any level from the pelvis to the popliteal fossa. Variations in the level of bifurcation of
Mayankkumar D Javia, Sanjay K Vikani
doaj   +1 more source

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source