Dexmedetomidine Improves Locomotor Function and Alleviates Thermal Hyperalgesia Following Sciatic Nerve Crush Injury in Rats [PDF]
International Neurourology Journal, 2020 Purpose The effects of dexmedetomidine on locomotor function and thermal hyperalgesia in sciatic nerve crush injury (SNCI) were investigated using rats.
Myung-Soo Jang +7 more
doaj +1 more source
Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes [PDF]
, 2015 Background: NOD-like receptors (Nlrs) are key regulators of immune responses during infection and autoimmunity. A subset of Nlrs assembles inflammasomes, molecular platforms that are activated in response to endogenous danger and microbial ligands and ...
De Winter, Vicky +6 more
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Neural Regeneration Research, 2018 Studies have confirmed that bone marrow-derived mesenchymal stem cells (MSCs) can be used for treatment of several nervous system diseases. However, isolation of bone marrow-derived MSCs (BMSCs) is an invasive and painful process and the yield is very ...
Marcela Fernandes +7 more
doaj +1 more source
ATF3 upregulation in glia during Wallerian degeneration: differential expression in peripheral nerves and CNS white matter [PDF]
, 2004 Background: Many changes in gene expression occur in distal stumps of injured nerves but the transcriptional control of these events is poorly understood.
Anderson, PN +6 more
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Journal of Nanobiotechnology, 2020 Background Peripheral nerve injury is one common clinical disease worldwide, in which sciatic nerve is anatomically the most challenging to regenerate given its length and large cross-sectional area.
Zhiwei Fang +5 more
doaj +1 more source
Evaluation methods of a rat sciatic nerve crush injury model
Journal of Integrative Neuroscience, 2022 Background: The rat sciatic nerve crush injury model is one of the most commonly used models to research peripheral nerve injury (PNI), however, the evaluation of the model preparation lacks exact standards.
Yun An +4 more
doaj +1 more source
Progranulin contributes to endogenous mechanisms of pain defense after nerve injury in mice [PDF]
, 2012 Progranulin haploinsufficiency is associated with frontotemporal dementia in humans. Deficiency of progranulin led to exaggerated inflammation and premature aging in mice.
Albuquerque, Boris +5 more
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Low-level laser irradiation improves functional recovery and nerve regeneration in sciatic nerve crush rat injury model. [PDF]
PLoS ONE, 2014 The development of noninvasive approaches to facilitate the regeneration of post-traumatic nerve injury is important for clinical rehabilitation. In this study, we investigated the effective dose of noninvasive 808-nm low-level laser therapy (LLLT) on ...
Chau-Zen Wang +7 more
doaj +1 more source
Activity of Cyclic AMP Phosphodiesterases and Adenylyl Cyclase in Peripheral Nerve after Crush and Permanent Transection Injuries [PDF]
, 1998 Recent studies demonstrate that cAMP levels are tightly controlled during demyelination and remyelination in Schwann cells as cAMP decreases to 8–10% of normal following both sciatic nerve crush or permanent transection injury and only begins to increase
Poduslo, Joseph F. +1 more
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Effect of melatonin supplemented at the light or dark period on recovery of sciatic nerve injury in rats [PDF]
, 2017 Peripheral nerve injuries can cause disabilities, social or economic problems. Melatonin, the secretory product of the pineal gland has antioxidant and anti-inflammatory actions.
Amin, Shaimaa Nasr +4 more
core +1 more source