Results 51 to 60 of about 56,654 (252)
Altered Excitability and Local Connectivity of mPFC-PAG Neurons in a Mouse Model of Neuropathic Pain [PDF]
, 2018 The medial prefrontal cortex (mPFC) plays a major role in both sensory and affective aspects of pain. There is extensive evidence that chronic pain produces functional changes within the mPFC.
Cheriyan, John, Sheets, Patrick L.
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TRPV1 agonist, capsaicin, induces axon outgrowth after injury via Ca2+/PKA signaling [PDF]
, 2018 Preconditioning nerve injuries activate a pro-regenerative program that enhances axon regeneration for most classes of sensory neurons. However, nociceptive sensory neurons and central nervous system neurons regenerate poorly.
DiAntonio, Aaron +4 more
core +2 more sources
Tanshinone IIA attenuates nerve structural and functional damage induced by nerve crush injury in rats. [PDF]
PLoS ONE, 2018 After peripheral nerve crush injury, the fibers of distal nerve segments gradually disintegrate, and axons regrow from the proximal nerve segment, eventually reaching the target organ.
Zhiyong Wang +4 more
doaj +1 more source
Sciatic neuropathy with preserved sensory nerve action potentials, a case series [PDF]
, 2020 Background: Sciatic neuropathy is differentiated from lumbosacral radiculopathy based on the finding of abnormal sensory nerve action potentials (SNAPs). Cases of sciatic neuropathy with intact SNAPS have not been well described. Methods: A retrospective
Li, Yuebing +2 more
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Advanced Science, EarlyView.We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin +17 more
wiley +1 more source
Loss of neurons from laminas I-III of the spinal dorsal horn is not required for development of tactile allodynia in the spared nerve injury model of neuropathic pain [PDF]
, 2005 It has been proposed that death of inhibitory interneurons in the dorsal horn contributes to the neuropathic pain that follows partial nerve injury. In this study, we have used two approaches to test whether there is neuronal death in the dorsal horn in ...
Arham, A.Z. +3 more
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Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
Molecular Pain, 2018 Objective Neural stem cells play an important role in the recovery and regeneration of peripheral nerve injury, and the microRNA-7 (miR-7) regulates differentiation of neural stem cells.
Nan Zhou +7 more
doaj +1 more source
Changes in microtubule-associated protein tau during peripheral nerve injury and regeneration
Neural Regeneration Research, 2016 Tau, a primary component of microtubule-associated protein, promotes microtubule assembly and/or disassembly and maintains the stability of the microtubule structure. Although the importance of tau in neurodegenerative diseases has been well demonstrated,
Guang-bin Zha +3 more
doaj +1 more source
Folia Morphologica, 2022 BACKGROUND: The sciatic nerve is a peripheral nerve and is more vulnerable to compression with subsequent short- or long-term neuronal dysfunction. The current study was designed to elucidate the possible ameliorative effect of L-carnitine and sildenafil
O. I. Zedan, M. A. Bashandy
doaj +1 more source