Results 71 to 80 of about 220,539 (258)

Sildenafil ameliorates long term peripheral neuropathy in type II diabetic mice. [PDF]

PLoS ONE, 2015
Diabetic peripheral neuropathy is a common complication of long-standing diabetes mellitus. To mimic clinical trials in which patients with diabetes enrolled have advanced peripheral neuropathy, we investigated the effect of sildenafil, a specific ...
Lei Wang, Michael Chopp, Alexandra Szalad, LongFei Jia, XueRong Lu, Mei Lu, Li Zhang, Yi Zhang, RuiLan Zhang, Zheng Gang Zhang   +9 more
doaj   +1 more source

Open Sciatic Nerve Decompression for Compartment Syndrome after Prolonged Lithotomy Position: A Case Report

Medicina, 2022
Background: Position-related compressive nerve injury is a frequently reported complication of the lithotomy position. In contrast, compartment syndrome-induced neuropathy after lithotomy with prolonged surgery is rare and prone to misdiagnosis.
Se-Hwan Lee, Hong-Pil Hwang, Sun-Jung Yoon   +2 more
doaj   +1 more source

Expression of Nrf2 Promotes Schwann Cell-Mediated Sciatic Nerve Recovery in Diabetic Peripheral Neuropathy

Cellular Physiology and Biochemistry, 2018
Background/Aims: High glucose-induced oxidative stress and inflammatory responses play an important role in painful diabetic neuropathy by activating the TLR4/NFκB signal pathway. Schwann cells (SCs) are integral to peripheral nerve biology, contributing
Wei-Yu Tang, Xiang-fang Chen, Haoqi Liu, Qian Lv, J. Zou, Yongquan Shi, Zhimin Liu   +6 more
semanticscholar   +1 more source

Crucifixion and median neuropathy. [PDF]

, 2013
Crucifixion as a means of torture and execution was first developed in the 6th century B.C. and remained popular for over 1000 years. Details of the practice, which claimed hundreds of thousands of lives, have intrigued scholars as historical records and
Regan, Jacqueline M, Shahlaie, Kiarash, Watson, Joseph C   +2 more
core   +1 more source

Diabetes-induced myelin abnormalities are associated with an altered lipid pattern: protective effects of LXR activation

Journal of Lipid Research, 2012
Diabetic peripheral neuropathy (DPN) is characterized by myelin abnormalities; however, the molecular mechanisms underlying such deficits remain obscure. To uncover the effects of diabetes on myelin alterations, we have analyzed myelin composition.
Gaia Cermenati, Federico Abbiati, Solei Cermenati, Elisabetta Brioschi, Alessandro Volonterio, Guido Cavaletti, Enrique Saez, Emma De Fabiani, Maurizio Crestani, Luis M. Garcia-Segura, Roberto C. Melcangi, Donatella Caruso, Nico Mitro   +12 more
doaj   +1 more source

Improvement of peripheral vascular impairment by a phosphodiesterase type 5 inhibitor tadalafil prevents oxaliplatin-induced peripheral neuropathy in mice

Journal of Pharmacological Sciences, 2019
Oxaliplatin, a platinum-based chemotherapeutic drug, frequently induces peripheral neuropathy. Accumulating evidences suggest a possible relationship between peripheral vascular impairment and peripheral neuropathy.
Takashi Ogihara, Takayuki Nakagawa, Maho Hayashi, Madoka Koyanagi, Atsushi Yonezawa, Tomohiro Omura, Shunsaku Nakagawa, Noriaki Kitada, Satoshi Imai, Kazuo Matsubara   +9 more
doaj   +1 more source

The Effect of Endurance Training on Fibronectin Gene Expression of the Sciatic Nerve in Diabetic Rats

Acta Medica Iranica, 2020
Diabetic neuropathy can cause disorders in axon transmission, changes in the extracellular matrix, and peripheral nerve damages. However, its mechanism, along with the beneficial effects of exercise on these disorders is not entirely clear.
Nahid Jalilian Hamed, Reza Gharakhanlou, Maghsoud Peeri   +2 more
doaj   +1 more source

Gene therapy targeting SARM1 blocks pathological axon degeneration in mice [PDF]

, 2019
Axonal degeneration (AxD) following nerve injury, chemotherapy, and in several neurological disorders is an active process driven by SARM1, an injury-activated NADase.
DiAntonio, Aaron, Doan, Ryan A, Geisler, Stefanie, Huang, Shay X, Mao, Xianrong, Milbrandt, Jeffrey, Park, Jiwoong, Strickland, Amy, Summers, Daniel W   +8 more
core   +1 more source

The alternatively spliced fibronectin CS1 isoform regulates IL-17A levels and mechanical allodynia after peripheral nerve injury. [PDF]

, 2015
BackgroundMechanical pain hypersensitivity associated with physical trauma to peripheral nerve depends on T-helper (Th) cells expressing the algesic cytokine, interleukin (IL)-17A.
Angert, Mila, Chernov, Andrei V, Dolkas, Jennifer, Hoang, Khan, Liu, Huaqing, Nishihara, Tasuku, Remacle, Albert G, Shiryaev, Sergey A, Shubayev, Veronica I, Strongin, Alex Y   +9 more
core   +3 more sources

Long-Term Treatment With Ranirestat (AS-3201), a Potent Aldose Reductase Inhibitor, Suppresses Diabetic Neuropathy and Cataract Formation in Rats

Journal of Pharmacological Sciences, 2008
We investigated the chronic functional and histopathological changes in the sciatic nerve and lens of streptozotocin (STZ)-diabetic rats and evaluated the preventive effects of ranirestat (AS-3201), a potent aldose reductase inhibitor, on these changes ...
Takafumi Matsumoto, Yoshiyuki Ono, Akemi Kuromiya, Kaoru Toyosawa, Yoshinaka Ueda, Vera Bril   +5 more
doaj   +1 more source