Prolonged conservative treatment or 'early' surgery in sciatica caused by a lumbar disc herniation: rationale and design of a randomized trial [ISRCT 26872154] [PDF]
Wilco C. Peul+7 more
openalex +1 more source
Weighted cart pull: A novel outcome measure for sustained motor function in mice
Abstract Sarcopenia, the pathological age‐related decline in muscle mass and strength, compromises independence and quality of life in older adults. Currently, no effective treatments are available. To enhance translational research using aged mouse models, we developed and validated the weighted cart pull (WCP) as a novel assessment of sustained motor
Charles D. Brennan+12 more
wiley +1 more source
DREAM: an adaptive, randomised, placebo-controlled trial of duloxetine for reducing leg pain in people with chronic sciatica-trial protocol. [PDF]
McLachlan H+11 more
europepmc +1 more source
Exercise oximetry in clinical practice: A single‐centre perspective on procedure and techniques
Abstract In moderate lower extremity artery disease (LEAD), when tissue ischaemia due to impaired inflow occurs at exercise but not during rest, exercise oximetry may be evaluated as a part of the diagnosis process. Initially used when assessing critical limb ischaemia at rest, transcutaneous oximetry (TcpO2) has also been used in the last two decades ...
Simon Lecoq+5 more
wiley +1 more source
Dorsal epidural disc migration-MRI characteristics and surgical microdiscectomy treatment: Case report and review of the literature. [PDF]
Michailidis A+5 more
europepmc +1 more source
Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity
Abstract figure legend Pannexin 1 (PANX1) regulation of dendritic spines. The postnatal decrease in PANX1 expression could release key spine cytoskeleton‐regulating proteins enabling spine stabilization. Does the physiological decrease in neuronal PANX1 levels across brain development underlie dendritic spine maturation?
Adriana Casillas Martinez+3 more
wiley +1 more source
Causal Effects of Artificially Sweetened Foods on Chronic Pain Mediated by Gut Microbiota: A Mendelian Randomization Study. [PDF]
Zhao H, Guan D, Dong X, Yao Y, Ma Z.
europepmc +1 more source